MALIGNANT NEOPLASMS IN AIDS NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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MALIGNANT NEOPLASMS IN AIDS

AIDS. Etiology, Diagnosis, Treatment, and Prevention. DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia, J. B. Lippincott Company, p. 213-22, 1985.. Unique Identifier : AIDSLINE ICDB/86616579
Safai B; Koziner B; Memorial Sloan-Kettering Cancer Center, New York, NY

Abstract: As the epidemic of acquired immunodeficiency syndrome (AIDS) spread, malignant neoplasms other than Kaposi's sarcoma (KS), such as lymphoma and squamous cell carcinoma, were reported with increasing frequency. The fact that a human retrovirus with oncogenic potential is involved in the pathogenesis of AIDS clearly suggests that AIDS victims are at a higher risk for developing cancer. The types and features of the malignancies reported thus far in AIDS are discussed under the following headings: immunodeficiency and cancer, oral and anorectal carcinomas, KS, and malignant lymphomas. Most of the malignant neoplasms seen in both AIDS and AIDS-related complex (ARC) are non-Hodgkin's lymphoma of B-cell phenotype, involving the CNS. The primary CNS lymphoma observed in AIDS resembles the lymphoreticular malignancies reported in patients (pts) with congenital and drug-induced immunodeficiencies. A common pathogenetic mechanism for development of the neoplasia could involve the activation of endogenous viruses or infection with exogenous viruses. In AIDS and ARC, it might be the human T-cell leukemia/lymphoma virus type III that is responsible for the immunodeficient environment necessary for activation of oncogenic virus. The expression of particular disorders might depend on the activation of different oncogenic pathways with different incubation periods or on the particular combination of oncogenic viruses, pathogens, and heterogenic stimulation that make up the individual pt's milieu. (63 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Brain Neoplasms/ETIOLOGY Human Lymphoma/ETIOLOGY Male Mouth Neoplasms/ETIOLOGY Neoplasms/*ETIOLOGY Rectal Neoplasms/ETIOLOGY Sarcoma, Kaposi's/ETIOLOGY Tumor Virus Infections/COMPLICATIONS MONOGRAPH REVIEW

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsbrainneoplasms/etiologyhumanlymphoma/etiologymalemouthneoplasms/etiologyneoplasms/KWDetiologyrectalneoplasms/etiologysarcoma,kaposi's/etiologytumorvirusinfections/complicationsmonographreview
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Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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