THE AIDS-RELATED COMPLEX NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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THE AIDS-RELATED COMPLEX

AIDS. Etiology, Diagnosis, Treatment, and Prevention. DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia, J. B. Lippincott Company, p. 223-33, 1985.. Unique Identifier : AIDSLINE ICDB/86616580
Ziegler JL; Abrams DI; Univ. of California, San Francisco, CA

Abstract: The discovery and characterization of the acquired immunodeficiency syndrome (AIDS) in 1981 in homosexual men was accompanied by the recognition of a new syndrome of unexplained lymphadenopathy, fatigue, fever, and wt loss, which also was prevalent in homosexual men. This latter syndrome was observed to be a milder form of AIDS or, in some cases, a prodrome to the development of Kaposi's sarcoma or opportunistic infections. Thus, the lymphadenopathy syndrome (LAS) and other variations (eg, idiopathic thrombocytopenic purpura) came to be grouped under the heading of AIDS-related complex (ARC). The clinical, laboratory, and pathologic features of LAS as a manifestation and prodrome of AIDS are described. Lymphadenopathy in a member of an AIDS risk group appears to be a mild clinical manifestation of infection by the lymphadenopathy-associated virus/human T-cell leukemia/lymphoma type III (LAV/HTLV-III) retrovirus. In up to 20% of cases, progression to more severe clinical illness may occur. Progression is heralded by histologic evidence of follicular atrophy and by the triad of constitutional symptoms, splenomegaly, and leukopenia. There is no successful treatment to date, and appropriate therapy will be derived only from better insights into immunopathogenesis. (68 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*DIAGNOSIS/ETIOLOGY/PATHOLOGY Herpesviridae Infections/COMPLICATIONS Human HTLV-BLV Viruses Lymph Nodes/PATHOLOGY Lymphatic Diseases/*COMPLICATIONS/IMMUNOLOGY/PATHOLOGY Male *Retroviridae Infections MONOGRAPH REVIEW

KWDacquiredimmunodeficiencysyndrome/KWDdiagnosis/etiology/pathologyherpesviridaeinfections/complicationshumanhtlv-blvviruseslymphnodes/pathologylymphaticdiseases/KWDcomplications/immunology/pathologymaleKWDretroviridaeinfectionsmonographreview
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Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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