AIDS: A GENERAL OVERVIEW NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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AIDS: A GENERAL OVERVIEW

AIDS. Etiology, Diagnosis, Treatment, and Prevention. DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia, J. B. Lippincott Company, p. 299-338, 1985.. Unique Identifier : AIDSLINE ICDB/86616584
Steis R; Broder S; Medicine Branch, Clinical Oncology Program, Div. of Cancer; Treatment, NCI, NIH, Bethesda, MD

Abstract: The acquired immunodeficiency syndrome (AIDS) is characterized by abnormal host defense mechanisms that predispose to infections with opportunistic organisms (Pneumocystis carinii; atypical mycobacteria; Cryptococcus neoformans; others), Kaposi's sarcoma (KS), and, less commonly, other neoplasms such as non-Hodgkin's lymphomas. To date, most cases of AIDS have occurred in people belonging to one of four categories: sexually active homosexual and bisexual men, present or past abusers of iv drugs, Haitian entrants into the United States, and individuals with hemophilia. An overview of the clinical and investigative aspects of AIDS and the neoplasms associated with this syndrome is provided. The entity of KS as it was known prior to recognition of AIDS is described, to compare it and contrast it with the AIDS-associated KS. Current therapeutic efforts in KS and their rationales are presented. The causation of AIDS and the implications for new therapeutic strategies based on the discovery of a novel human T-cell lymphotropic retrovirus in this disease are discussed. Other topics discussed include clinical laboratory evaluation, current experimental treatments for KS in AIDS, and etiology of AIDS. (199 Refs)
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/*DIAGNOSIS/ EPIDEMIOLOGY/ETIOLOGY/THERAPY Africa Antineoplastic Agents, Combined/THERAPEUTIC USE Hematologic Diseases/ETIOLOGY Human Hypergammaglobulinemia/ETIOLOGY HTLV-BLV Viruses Infection/COMPLICATIONS Interferons/THERAPEUTIC USE Lymphoma/COMPLICATIONS Retroviridae Infections Sarcoma, Kaposi's/COMPLICATIONS/EPIDEMIOLOGY/THERAPY United States MONOGRAPH REVIEW

KWDacquiredimmunodeficiencysyndrome/complications/
860330
M8630200

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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