Defective human T-cell leukemia virus in adult T-cell leukemia patients. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Defective human T-cell leukemia virus in adult T-cell leukemia patients.

Mol Biol Med. 1984 Aug;2(4):273-83. Unique Identifier : AIDSLINE MED/86064882
Konishi H; Kobayashi N; Hatanaka M

Abstract: Human T-cell leukemia virus (HTLV) is associated with adult T-cell leukemia (ATL). We have examined the state of the HTLV provirus in the leukemic cells of ATL patients, and found that all the circulating leukemic cells of ATL proliferated monoclonally with one or more proviral integrations. Unexpectedly, we observed a high incidence of multiple integration of the provirus that also revealed a clonality and therefore occurred prior to the clonal origin of the ATL cells. Several ATL patients contained defective proviruses in fresh leukemic cells. These defective proviruses varied with respect to the deleted portions of the HTLV genome when a full genome of the HTLV provirus was present in the ATL tumor cells. In contrast, ATL cells harboring only a defective provirus invariably retained a common sequence of env-pX-LTR. This is consistent with a model that implies that the preserved env-pX-LTR region of HTLV must have played an important role(s) at a certain stage in ATL leukemogenesis after proviral integration. This is the first indication that the whole HTLV genome is not necessarily required to initiate or maintain the monoclonal proliferation of ATL leukemic cells in patients.
Keywords: Defective Viruses/*GENETICS DNA Restriction Enzymes/DIAGNOSTIC USE Female Genes, Viral Human HTLV-BLV Viruses/*GENETICS Leukemia/GENETICS/*MICROBIOLOGY Male Support, Non-U.S. Gov't T-Lymphocytes/MICROBIOLOGY JOURNAL ARTICLE

KWDdefectiveviruses/KWDgeneticsdnarestrictionenzymes/diagnosticusefemalegenes,viralhumanhtlv-blvviruses/KWDgeneticsleukemia/genetics/KWDmicrobiologymalesupport,non-uKWDsKWDgov'tt-lymphocytes/microbiologyjournalarticle
860330
M8630191

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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