Urinary excretion of modified nucleosides in patients with acquired immune deficiency syndrome (AIDS) and individuals at high risk of AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Urinary excretion of modified nucleosides in patients with acquired immune deficiency syndrome (AIDS) and individuals at high risk of AIDS.

Cancer Detect Prev. 1985;8(1-2):271-7. Unique Identifier : AIDSLINE MED/86053355
Fischbein A; Sharma OK; Valciukas JA; Bekesi JG; Buschman F; Apell G; Kohn M; Boesch RR; Teirstein A; Selikoff IJ; et al

Abstract: Patients with certain malignant diseases excrete in their urine elevated levels of modified nucleosides originating from breakdown of transfer RNA (tRNA). A high incidence of acquired immune deficiency syndrome (AIDS), often associated with rapidly progressing Kaposi's sarcoma (KS), is currently being observed in many countries. Male homosexuals are considered to be at highest risk of developing these disorders. We have examined 10 patients with AIDS and 77 male homosexuals without clinical manifestations of AIDS at the time of examination. Elevated levels of modified nucleosides were found in all patients with AIDS. Of further interest was the finding of a high prevalence of abnormal nucleoside levels in the high-risk group, with a trend toward higher levels in those high-risk individuals who had lymphadenomegaly, considered a prodrome of AIDS. These findings indicate that determination of urinary nucleoside levels may help identify individuals at high risk of developing AIDS thereby increasing the possibility for prevention and early therapy.
Keywords: Acquired Immunodeficiency Syndrome/DIAGNOSIS/*URINE Adult Age Factors Aged Homosexuality Human Male Middle Age Nucleosides/*URINE Risk Smoking JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/diagnosis/KWDurineadultagefactorsagedhomosexualityhumanmalemiddleagenucleosides/KWDurinerisksmokingjournalarticle
860330
M8630186

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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