Ultrastructure of Kaposi's sarcoma in acquired immune deficiency syndrome (AIDS). NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Ultrastructure of Kaposi's sarcoma in acquired immune deficiency syndrome (AIDS).

Arch Otorhinolaryngol. 1985;242(3):305-13. Unique Identifier : AIDSLINE MED/86076579
Schenk P; Konrad K

Abstract: We used electron microscopy to examine the ultrastructural morphology of Kaposi's sarcoma (KS) of the oral mucosa in patients with acquired immune deficiency syndrome (AIDS). The tumors manifested endothelial vascular proliferation and neoplastic spindle cell formations. The endothelial tumor cells contained several multivesicular bodies and a large number of tubuloreticular structures within the endoplasmic reticulum. Ultrastructural changes in the other cytoplasmic organelles included defective cell junctions that seemed to facilitate the migration and extravasation of erythrocytes through endothelial gaps, after which erythrophagocytosis occurred. Tumor cells contained viral particles which were 100-120 nm in diameter and contained dense cylindrical cores. We believe that this is the first time these particles have been identified in KS cells of the oral mucosa in patients with AIDS. These viral particles are also ultrastructurally identical to the human T-cell lymphotropic retroviruses subgroup HTLV-III. Our observations are discussed in the light of recent immunological findings.
Keywords: Acquired Immunodeficiency Syndrome/*PATHOLOGY Adult Endothelium/PATHOLOGY/ULTRASTRUCTURE Erythrocytes/ULTRASTRUCTURE Head and Neck Neoplasms/PATHOLOGY/*ULTRASTRUCTURE Human Male *Mouth Mucosa Mouth Neoplasms/PATHOLOGY/*ULTRASTRUCTURE Phagocytosis Sarcoma, Kaposi's/PATHOLOGY/*ULTRASTRUCTURE Skin Neoplasms/PATHOLOGY/*ULTRASTRUCTURE Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDpathologyadultendothelium/pathology/ultrastructureerythrocytes/ultrastructureheadandneckneoplasms/pathology/KWDultrastructurehumanmaleKWDmouthmucosamouthneoplasms/pathology/KWDultrastructurephagocytosissarcoma,kaposi's/pathology/KWDultrastructureskinneoplasms/pathology/KWDultrastructuresupport,non-uKWDsKWDgov'tjournalarticle
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M8630152

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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