Chromosome aberrations in peripheral lymphocytes of male homosexuals. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Chromosome aberrations in peripheral lymphocytes of male homosexuals.

Cancer Genet Cytogenet. 1985 Dec;18(4):337-50. Unique Identifier : AIDSLINE MED/86053040
Manolov G; Manolova Y; Sonnabend J; Lipscomb H; Purtilo DT

Abstract: Karyotypes of peripheral lymphocytes of 19 male homosexuals showed increased hypodiploidy. Chromosomes #19 and #20 were most frequently lost. Also, structural chromosome aberrations frequently occurred consisting chiefly of translocations and simple chromosome breaks. Terminal deletions, inversions, and isochromosomes occurred less commonly. In three of the cases, 100% of the cells were involved in a pericentric inversion of a chromosome #9. Chromosomes #3 in p21.1 and 1 in p32.3 were repeatedly affected. Structural aberrations were seen less frequently in men with acquired immunodeficiency syndrome(AIDS) and AIDS-related complex than in asymptomatic homosexuals. The hypodiploidy with preferential loss of chromosomes was constantly present. The marker chromosomes and simple breaks at repeated sites are another manifestation of damage to the immune system in these male homosexuals from Greenwich Village in New York City. The chromosomal damage was potentially the result of exposure to amyl and butyl nitrites, viral infections, or immunologic reactions to sperm, which crossreact with lymphocytes.
Keywords: Acquired Immunodeficiency Syndrome/*GENETICS Adult *Chromosome Aberrations Genetic Markers *Homosexuality Human Karyotyping Lymphocytes/ULTRASTRUCTURE Male Middle Age Ploidies Translocation (Genetics) JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDgeneticsadultKWDchromosomeaberrationsgeneticmarkersKWDhomosexualityhumankaryotypinglymphocytes/ultrastructuremalemiddleageploidiestranslocation(genetics)journalarticle
860330
M8630140

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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