Circulating IgA immune complexes in AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Circulating IgA immune complexes in AIDS.

Immunol Invest. 1985 Aug;14(4):341-5. Unique Identifier : AIDSLINE MED/86057817
Lightfoote MM; Folks TM; Redfield R; Gold J; Sell KW

Abstract: Circulating immune complexes were isolated from the serum of patients with AIDS, as well as patients with other acute and chronic viral diseases. Analysis of these immune complexes by methods of flow cytometry and by radioimmune (Raji cell) assay revealed a prevalence of IgA complexes in the serum of AIDS patients and a prevalence of IgG complexes in the serum of patients with other viral diseases. Raji cells bind immune complexes via Fc and complement (C3) receptors and may detect IgA immune complexes more efficiently than a C1q assay since IgA has no affinity for C1q.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Antigen-Antibody Complex/*ANALYSIS Complement Activating Enzymes Flow Cytometry Human IgA/*ANALYSIS IgG/ANALYSIS Radioimmunoassay Virus Diseases/IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyantigen-antibodycomplex/KWDanalysiscomplementactivatingenzymesflowcytometryhumaniga/KWDanalysisigg/analysisradioimmunoassayvirusdiseases/immunologyjournalarticle
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M8630128

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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