Monoclonal antibody-defined beta 2-microglobulin-positive mononuclear cells in acquired immune deficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Monoclonal antibody-defined beta 2-microglobulin-positive mononuclear cells in acquired immune deficiency syndrome.

Scand J Immunol. 1985 Oct;22(4):357-61. Unique Identifier : AIDSLINE MED/86070004
Gupta S

Abstract: In healthy heterosexuals, by means of a monoclonal antibody against beta 2-microglobulin (beta 2m) and fluorescence-activated cell sorter analyser (FACS analyser), we observed two populations of beta 2m+ mononuclear cells (MNC); a large population with high-intensity cells and a small population of relatively low-intensity cells. Because elevated beta 2m levels have been shown in the sera of patients with acquired immune deficiency syndrome (AIDS), we examined the proportions of beta 2m+ MNC in AIDS and AIDS-related complex (ARC). The proportions and numbers of high-fluorescence intensity beta 2m+ MNC were significantly (P less than 0.05) decreased in AIDS and ARC when compared with those of asymptomatic homosexuals and healthy heterosexuals. The proportion and number of total beta 2m+ MNC (both high- and low-intensity beta 2m+) in ARC were comparable to those of control groups; however, the numbers of total beta 2m+ MNC were significantly (P less than 0.01) reduced only in the AIDS group. This relative deficiency of high-intensity beta 2m+ MNC appears to be due to a shift from high-intensity beta 2m+ to low-intensity beta 2m+ MNC. A linear correlation was observed between the deficiency of high-intensity beta 2m+ cells and T helper to T suppressor phenotype cell ratios.
Keywords: beta 2-Microglobulin/*IMMUNOLOGY Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Antibodies, Monoclonal/DIAGNOSTIC USE Antigens, Surface/ANALYSIS Flow Cytometry Homosexuality Human Lymphatic Diseases/IMMUNOLOGY Monocytes/*IMMUNOLOGY Sarcoma, Kaposi's/IMMUNOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/IMMUNOLOGY JOURNAL ARTICLE

KWDbeta2-microglobulin/KWDimmunologyacquiredimmunodeficiencysyndrome/KWDimmunologyantibodies,monoclonal/diagnosticuseantigens,surface/analysisflowcytometryhomosexualityhumanlymphaticdiseases/immunologymonocytes/KWDimmunologysarcoma,kaposi's/immunologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/immunologyjournalarticle
860330
M8630119

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1986. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1986. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .