AIDS. Etiology, Diagnosis, Treatment, and Prevention. DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia, J. B. Lippincott Company, 352 p., 1985.. Unique Identifier : AIDSLINE ICDB/86616571
Anonymous; No affiliation given
Acquired immune deficiency syndrome (AIDS) has reached epidemic proportions in the United States since the first cases were reported in 1981. The numbers of AIDS cases are increasing and the disease is fatal; of those patients who have been diagnosed for three yr or more, 85% have died
The acquired immunodeficiency syndrome (AIDS) is a highly lethal epidemic that was first reported in May, 1981. It appears to be a truly new condition in each of the populations it has affected, and a host of theories have been offered about its origins and etiology. The current understanding of the epidemiology of AI
The acquired immunodeficiency syndrome (AIDS) was first recognized in 1981 as a unique clinical syndrome consisting of opportunistic infection and/or neoplasia, associated with unexplained immunodeficiency. Events leading to the discovery of human T-cell leukemic virus Type III (HTLV-III), the virus that causes AIDS,
The acquired immunodeficiency syndrome (AIDS) is a new epidemic that continues to expand at a rapid rate without showing signs of ablation. Prospects for diagnostic tests, intervention, and vaccine development in AIDS are discussed under the following headings: disease states and mode of transmission, isolation of hum
AIDS. Etiology, Diagnosis, Treatment, and Prevention. DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia, J. B. Lippincott Company, p. 89-109, 1985.. Unique Identifier : AIDSLINE ICDB/86616575
Bowen DL; Lane HC; Fauci AS; Lab. of Immunoregulation, Natl. Inst. of Allergy and Infectious; Diseases, NIH, Bethesda, MD
The etiologic agent of the acquired immunodeficiency syndrome (AIDS) has been recently identified as a retrovirus of the human T-cell leukemia/lymphoma virus (HTLV) family, HTLV-III. It is likely that this virus is identical with lymphadenopathy-associated virus (LAV). Immunologic features of AIDS are discussed under
AIDS. Etiology, Diagnosis, Treatment, and Prevention. DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia, J. B. Lippincott Company, p. 111-60, 1985.. Unique Identifier : AIDSLINE ICDB/86616576
Reichert CM; Kelly VL; Macher AM; Lab. of Pathology, NCI, NIH, Bethesda, MD
The surgical and autopsy features of the acquired immunodeficiency syndrome (AIDS) can be divided into three major categories: morphologic manifestations of immunologic impairment; infections, often mixed opportunistic pathogens; and neoplasms (most frequently Kaposi s sarcoma and non-Hodgkin s lymphomas). The gross,
AIDS. Etiology, Diagnosis, Treatment, and Prevention. DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia, J. B. Lippincott Company, p. 161-84, 1985.. Unique Identifier : AIDSLINE ICDB/86616577
Masur H; Kovacs JA; Ognibene F; Shelhamer J; Parrillo JE; Critical Care Medicine Dept., Clinical Center, NIH, Bethesda, MD
Opportunistic infections ultimately develop in almost every patient (pt) with acquired immunodeficiency syndrome (AIDS). Most AIDS pts develop multiple infectious processes and die either because there is no effective therapy available for the pathogen that is causing systemic disease or because they no longer can res
AIDS. Etiology, Diagnosis, Treatment, and Prevention. DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia, J. B. Lippincott Company, p. 185-211, 1985.. Unique Identifier : AIDSLINE ICDB/86616578
Krigel RL; Friedman-Kien AE; Fox Chase Cancer Center, Philadelphia, PA
The underlying immunologic deficiency that characterizes acquired immunodeficiency syndrome (AIDS) is an acquired profound disorder of cell-mediated immune functions. This immunologic deficiency predisposes the host to a variety of opportunistic infections and unusual neoplasms, especially the previously uncommon tumo
AIDS. Etiology, Diagnosis, Treatment, and Prevention. DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia, J. B. Lippincott Company, p. 213-22, 1985.. Unique Identifier : AIDSLINE ICDB/86616579
Safai B; Koziner B; Memorial Sloan-Kettering Cancer Center, New York, NY
As the epidemic of acquired immunodeficiency syndrome (AIDS) spread, malignant neoplasms other than Kaposi s sarcoma (KS), such as lymphoma and squamous cell carcinoma, were reported with increasing frequency. The fact that a human retrovirus with oncogenic potential is involved in the pathogenesis of AIDS clearly sug
AIDS. Etiology, Diagnosis, Treatment, and Prevention. DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia, J. B. Lippincott Company, p. 223-33, 1985.. Unique Identifier : AIDSLINE ICDB/86616580
Ziegler JL; Abrams DI; Univ. of California, San Francisco, CA
The discovery and characterization of the acquired immunodeficiency syndrome (AIDS) in 1981 in homosexual men was accompanied by the recognition of a new syndrome of unexplained lymphadenopathy, fatigue, fever, and wt loss, which also was prevalent in homosexual men. This latter syndrome was observed to be a milder fo
AIDS. Etiology, Diagnosis, Treatment, and Prevention. DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia, J. B. Lippincott Company, p. 235-63, 1985.. Unique Identifier : AIDSLINE ICDB/86616581
Lotze MT; NCI, NIH, Bethesda, MD
Treatment of immunologic disorders in acquired immunodeficiency syndrome (AIDS) is discussed under the following headings: immunologic defects and possible strategies, interferon trials (alpha interferon; gamma interferon), interleukin-2 trials, thymic hormones and factors, and other immunologic interventions (pharmac
AIDS. Etiology, Diagnosis, Treatment, and Prevention. DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia, J. B. Lippincott Company, p. 265-73, 1985.. Unique Identifier : AIDSLINE ICDB/86616582
Safai B; Memorial Sloan-Kettering Cancer Center, New York, NY
There is no reliable means of prevention available for acquired immunodeficiency syndrome (AIDS). It is well documented that AIDS is mainly transmitted by sexual contact and by blood and blood products. However, it is unclear whether the AIDS virus (human T-cell leukemia/lymphoma virus Type III) can be transmitted by
AIDS. Etiology, Diagnosis, Treatment, and Prevention. DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia, J. B. Lippincott Company, p. 275-97, 1985.. Unique Identifier : AIDSLINE ICDB/86616583
Christ GH; Wiener LS; Dept. of Social Work, Memorial Sloan-Kettering Cancer Center, New; York, NY
The complexity of problems confronting people with acquired immunodeficiency syndrome (AIDS) and the psychosocial problems it engenders set this disease apart from virtually every other contemporary public health problem. AIDS remains incurable. Currently, treatments are available for specific opportunistic infections
AIDS. Etiology, Diagnosis, Treatment, and Prevention. DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia, J. B. Lippincott Company, p. 299-338, 1985.. Unique Identifier : AIDSLINE ICDB/86616584
Steis R; Broder S; Medicine Branch, Clinical Oncology Program, Div. of Cancer; Treatment, NCI, NIH, Bethesda, MD
The acquired immunodeficiency syndrome (AIDS) is characterized by abnormal host defense mechanisms that predispose to infections with opportunistic organisms (Pneumocystis carinii; atypical mycobacteria; Cryptococcus neoformans; others), Kaposi s sarcoma (KS), and, less commonly, other neoplasms such as non-Hodgkin s
Human T-cell leukemia virus (HTLV) is associated with adult T-cell leukemia (ATL). We have examined the state of the HTLV provirus in the leukemic cells of ATL patients, and found that all the circulating leukemic cells of ATL proliferated monoclonally with one or more proviral integrations. Unexpectedly, we observed
Cancer Detect Prev. 1985;8(1-2):271-7. Unique Identifier : AIDSLINE MED/86053355
Fischbein A; Sharma OK; Valciukas JA; Bekesi JG; Buschman F; Apell G; Kohn M; Boesch RR; Teirstein A; Selikoff IJ; et al
Patients with certain malignant diseases excrete in their urine elevated levels of modified nucleosides originating from breakdown of transfer RNA (tRNA). A high incidence of acquired immune deficiency syndrome (AIDS), often associated with rapidly progressing Kaposi s sarcoma (KS), is currently being observed in many
Incubation of serum and plasma samples at 56 degrees C for 30 min inactivates the HTLV-III virus. We assessed the effect of this procedure on results of routine biochemical tests by dividing samples of serum and plasma into two, heat-treating one while the other remained at room temperature. Samples were then analyzed
Poli G; Introna M; Zanaboni F; Peri G; Carbonari M; Aiuti F; Lazzarin A; Moroni M; Mantovani A
We have investigated 25 intravenous drug abusers with the clinical and laboratory features of lymphadenopathy syndrome (LAS) and 10 AIDS patients for the expression of NK activity. LAS and AIDS patients had low NK cytotoxicity compared to normal donors. The defective NK cytotoxicity was analysed in the eight LAS subje
A 9-year-old with immunodeficiency developed a severe, diffuse respiratory illness that necessitated mechanical ventilation. Open lung biopsy revealed Respiratory Syncytial Virus (RSV) as the sole pathogen. RSV detection should be included in the differential diagnosis of diffuse lung disease in an immunocompromised c
Children with acquired immune deficiency syndrome (AIDS) display two types of clinical picture: a full-blown AIDS characterized by the presence of opportunistic infections and/or Kaposi s sarcoma and a prodromal stage now identified as AIDS-related complex (ARC). Neurological complications have been identified in infa
During a one month period liver biopsy was carried out on eight patients with established acquired immune deficiency syndrome (AIDS) and two suspected of having AIDS to evaluate raised liver enzymes or unexplained fever and weight loss. Each of the 10 patients were found to have hepatic granulomas. Appropriate stainin
The removal of immune complexes, autoantibodies and suppressor factors from the circulation of patients with AIDS and AIDS related conditions by plasmapheresis and selective immunoadsorption may play a role as a therapeutic modality in these disorders. Lymphocytapheresis may also be of potential use in AIDS related co
Med Hypotheses. 1985 Sep;18(1):61-77. Unique Identifier : AIDSLINE MED/86065001
Cathcart RF 3d
The amount of oral ascorbic acid that a patient can tolerate without diarrhea, increases somewhat proportionately to the toxicity of his disease. Clinically, in a disease ameliorated by ascorbate, there is a suppression of symptoms only with very high doses and approximately to that extent which a nonrate-limited, ant
Severe unrelenting weight loss appears to be a major component of the clinical picture seen in the patients with Acquired Immune Deficiency Syndrome (AIDS). Weight loss has been associated with a poor prognosis for AIDS patients with Kaposi s sarcoma. Strong evidence from a variety of clinical situations indicates tha
Abe T; Kazama M; Kinoshita T; Matuda J; Yoshimura Y; Ryu T; Takahashi I
This report describes the first two Japanese cases of AIDS developed in patients with hemophilia. One was a 48-year-old man with hemophilia B and the other was a 62-year-old patient with hemophilia A. They had nonspecific prodromal syndromes of AIDS initially, and later developed fatal opportunistic infections with Ca
We used electron microscopy to examine the ultrastructural morphology of Kaposi s sarcoma (KS) of the oral mucosa in patients with acquired immune deficiency syndrome (AIDS). The tumors manifested endothelial vascular proliferation and neoplastic spindle cell formations. The endothelial tumor cells contained several m
A case of spontaneous rupture of the spleen is described in a 25-year-old woman with a history of intravenous drug abuse. At autopsy the spleen and the lymph nodes were soft, slightly enlarged, and markedly congested. They showed reactive follicular hyperplasia with increased cellularity and prominent vascularity of t
Karyotypes of peripheral lymphocytes of 19 male homosexuals showed increased hypodiploidy. Chromosomes #19 and #20 were most frequently lost. Also, structural chromosome aberrations frequently occurred consisting chiefly of translocations and simple chromosome breaks. Terminal deletions, inversions, and isochromosomes
Ross RK; Casagrande JT; Dworsky RL; Levine A; Mack T
The demographic characteristics of classic Kaposi s sarcoma (KS) and of epidemic KS in Los Angeles, CA, were compared with the use of data from the Cancer Surveillance Program, the population-based tumor registry in Los Angeles County. The data obtained document the magnitude of the excess risk of classic KS for Jewis
The acquired immune deficiency syndrome (AIDS) is characterized by a selective suppression of the immune system that renders patients susceptible to infection by a variety of opportunistic organisms. Among these is Mycobacterium avium intracellulare. AIDS victims often have oral manifestations of Kaposi s sarcoma and
S Afr Med J. 1985 Dec 7;68(12):843-8. Unique Identifier : AIDSLINE MED/86070684
Sher R
The aetiology, transmission, clinical spectrum, complicating opportunistic infections and neoplasias (such as Kaposi s sarcoma) and the diagnosis of acquired immune deficiency syndrome (AIDS) are described. Precautions to be observed by health care workers with regard to the handling of patients with AIDS and AIDS-rel
Body composition studies were performed in 33 patients suffering from the acquired immunodeficiency syndrome (AIDS). Studies included measurements of total body potassium, fat, and total body and extracellular water volumes plus serum retinol binding protein concentration, iron binding capacity, and albumin concentrat
Heron CW; Hine AL; Pozniak AL; Swinburn CR; Johnson NM
The radiographic findings in 14 episodes of pulmonary pathology, occurring in 13 patients with the acquired immune deficiency syndrome (AIDS) are described. The patients presented over a 15-month period. All were homosexual men with serum antibodies to human T-cell lymphotrophic virus III. Pneumocystis carinii pneumon
Hospital records were reviewed on 78 consecutive patients (33 homosexuals, 37 Haitians and 8 IV drug abusers) who had AIDS and who underwent fiberoptic bronchoscopy over a two year period. Pneumocystis carinii pneumonia (PCP) was the most common bronchoscopic finding (53.8% of patients) followed by tuberculosis (14.1%
Circulating immune complexes were isolated from the serum of patients with AIDS, as well as patients with other acute and chronic viral diseases. Analysis of these immune complexes by methods of flow cytometry and by radioimmune (Raji cell) assay revealed a prevalence of IgA complexes in the serum of AIDS patients and
Morgan J; Waring NP; Daul CB; Ohene-Frempong K; deShazo RD
We report the results of an immunologic evaluation of two hypertransfused (HT) patients with sickle-cell disease (SCD) who have developed persistent generalized lymphadenopathy. In order to interpret the results of this evaluation, we studied seven other HT patients with SCD and seven nonhypertransfused patients with
Proc Natl Acad Sci U S A. 1985 Nov;82(22):7748-52. Unique Identifier : AIDSLINE MED/86067983
Dowbenko DJ; Bell JR; Benton CV; Groopman JE; Nguyen H; Vetterlein D; Capon DJ; Lasky LA
A retrovirus [lymphoadenopathy-associated virus, human T-cell leukemia virus type III, acquired immunodeficiency syndrome (AIDS)-related virus] suspected of causing AIDS has been isolated recently. The detection of exposure to this retrovirus in donors of various blood products is important to prevent transmission of
Sensakovic JW; Suarez M; Perez G; Johnson ES; Smith LG
A 31-year-old man with acquired immunodeficiency syndrome and biopsy-proved Pneumocystis carinii pneumonia developed acute renal failure, elevated creatinine kinase levels, and myoglobin in both serum and urine while being treated with pentamidine. The patient was receiving no other nephrotoxic medications at the time
N Engl J Med. 1985 Dec 12;313(24):1504-10. Unique Identifier : AIDSLINE MED/86065316
Murray HW; Hillman JK; Rubin BY; Kelly CD; Jacobs JL; Tyler LW; Donelly DM; Carriero SM; Godbold JH; Roberts RB
We studied 81 men (79 homosexuals and 2 drug abusers) with persistent lymphadenopathy to determine whether those at risk for AIDS-related opportunistic infections could be identified prospectively. (Sixty-nine of 76 [91 per cent] had antibodies to human T-cell lymphotropic virus Type III [HTLV-III], and 76 of 79 [96 p
Public Health Rep. 1985 Nov-Dec;100(6):622-9. Unique Identifier : AIDSLINE MED/86068773
McKusick L; Wiley JA; Coates TJ; Stall R; Saika G; Morin S; Charles K; Horstman W; Conant MA
We surveyed 454 men in November 1983 and in May 1984 regarding their sexual practices during the month before the survey. In the 1983 survey, we also asked for reports about sexual behavior during the same month 1 year prior to the survey. The sample consisted of men recruited as they left bath-houses and bars, men wh
In healthy heterosexuals, by means of a monoclonal antibody against beta 2-microglobulin (beta 2m) and fluorescence-activated cell sorter analyser (FACS analyser), we observed two populations of beta 2m+ mononuclear cells (MNC); a large population with high-intensity cells and a small population of relatively low-inte
A prospective study compared the abilities of high-resolution computed tomography (HRCT) and magnetic resonance (MR) imaging in detection and evaluation of central nervous system disease in neurologically symptomatic patients with acquired immunodeficiency syndrome (AIDS). Eighteen CT scans and 19 MR images in 14 pati
Am J Epidemiol. 1986 Jan;123(1):162-73. Unique Identifier : AIDSLINE MED/86074123
Weinberg CR
In epidemiologic case-control studies and occupational cohort studies involving more than one exposure, it is sometimes of interest to investigate the possibility that two exposures or factors have an effect that is mutually enhancing. This paper begins with a simple classic model for independence of effect and descri
On review of 63 barium sulfate examinations in 44 patients with acquired immunodeficiency syndrome (AIDS), 61% of the 23 single-contrast examinations and 98% of the 40 double-contrast examinations were abnormal. Abnormalities involved all areas of the gastrointestinal (GI) tract and covered a wide spectrum of findings
Ann Intern Med. 1986 Jan;104(1):38-41. Unique Identifier : AIDSLINE MED/86075433
Polsky B; Gold JW; Whimbey E; Dryjanski J; Brown AE; Schiffman G; Armstrong D
Eighteen episodes of community-acquired bacterial pneumonia were diagnosed in 13 patients among 336 with the acquired immunodeficiency syndrome (AIDS) cared for at Memorial Sloan-Kettering Cancer Center since 1979. Bacterial pathogens isolated in 16 of 18 episodes were Haemophilus influenzae in 8, Streptococcus pneumo
Jeffrey RB Jr; Nyberg DA; Bottles K; Abrams DI; Federle MP; Wall SD; Wing VW; Laing FC
Acquired immunodeficiency syndrome (AIDS) is a lethal infectious disease that has reached epidemic proportions in urban centers of the United States . Intraabdominal opportunistic infections and malignancies are common features of this syndrome. A prodromal phase or possibly milder form
Cancer Res. 1986 Jan;46(1):417-25. Unique Identifier : AIDSLINE MED/86053253
Vadhan-Raj S; Wong G; Gnecco C; Cunningham-Rundles S; Krim M; Real FX; Oettgen HF; Krown SE
Multivariate analysis was used to identify which of a large number of pretreatment immunological parameters correlated with therapeutic response, subsequent development of opportunistic infection, and survival from the time of diagnosis in a group of 70 patients with Kaposi s sarcoma and acquired immunodeficiency synd
Duffy LF; Daum F; Kahn E; Teichberg S; Pahwa R; Fagin J; Kenigsberg K; Kaplan M; Fisher SE; Pahwa S
Hepatic morphology and immunocytology were evaluated in 4 children with clinical and immunologic characteristics of the acquired immune deficiency syndrome or acquired immune deficiency syndrome related complex. All 4 children had hepatomegaly and increased serum alanine and aspartate aminotransferase activity. Both l
Presse Med. 1985 Nov 2;14(37):1921-5. Unique Identifier : AIDSLINE MED/86067778
Goldman M; Abramowicz D; Bruyns C
Allogeneic interactions associated with experimental graft-versus-host reaction are sometimes responsible for the development of autoantibodies, immune complex lesions and malignant lymphocytic proliferation. Hypergammaglobulinaemia reflects the activation of B cells, and T cell-associated responses are deeply depress
Human T cell leukemia virus type II (HTLV-II) has been isolated from a patient (Mo) with features of leukemic reticuloendotheliosis (LRE) and from a patient with acquired immunodeficiency syndrome (AIDS). We have obtained another isolate of HTLV-II from a patient (CM) with severe hemophilia A, pancytopenia, and a 14-y
Kitchen L; Leal M; Wichmann I; Lissen E; Ollero M; Allan JS; McLane MF; Essex M
We tested serum samples from 50 hemophiliacs from Sevilla, Spain , for antibody to HTLV-III by indirect membrane immunofluorescence (IMI) and radioimmunoprecipitation with SDS polyacrylamide gel electrophoresis (RIP-SDS/PAGE). All had received commercial clotting factors from the
Cancer Genet Cytogenet. 1986 Jan 1;19(1-2):73-80. Unique Identifier : AIDSLINE MED/86053061
Harper ME; Marselle LM
In situ hybridization offers a direct approach for localization and quantitation of nucleic acid sequences in cellular preparations. Recent improvements in technology and methodology make possible the detection of DNA and RNA of relatively low copy number. For example, development of in situ hybridization methods for
Cancer Res. 1986 Jan;46(1):293-9. Unique Identifier : AIDSLINE MED/86053234
Haga S; Tanaka H; Tsujimoto H; Hayami M
Simian retroviruses closely related to human T-cell leukemia virus type I (HTLV-I) were isolated from 8 species, examined by both conventional and thin section immunocolloidal gold electron microscopy, and compared with HTLV-I. Mature forms of simian viruses were found in extracellular aggregates and within cytoplasmi
Poli G; Bottazzi B; Acero R; Bersani L; Rossi V; Introna M; Lazzarin A; Galli M; Mantovani A
We have investigated monocyte function in 17 intravenous drug abusers with the clinical and laboratory features of lymphadenopathy syndrome (LAS). LAS patients had normal numbers of circulating monocytes. Monocytes from LAS patients were comparable to cells from normal donors in terms of phagocytosis of latex beads, i
Kurata A; Katamine S; Fukuda T; Mine M; Ikari N; Kanazawa H; Matsunaga M; Eguchi K; Nagataki S
Human T-cell leukaemia virus (HTLV1/ATLV), which causes adult T cell leukaemia (ATL), is an infectious, lymphotrophic retrovirus unique for humans. The present study was undertaken to determine whether HTLV1 had any pathogenetic role for systemic lupus erythematosus (SLE). The incidence of antibodies to ATL cell-assoc
Gen Hosp Psychiatry. 1985 Oct;7(4):280-93. Unique Identifier : AIDSLINE MED/86056901
Wolcott DL; Fawzy FI; Pasnau RO
Acquired Immune Deficiency Syndrome (AIDS) is a new highly lethal transmissible syndrome that occurs primarily in identified high-risk groups. The number of AIDS cases has been doubling approximately every 6 months in the United States since 1981. A large number of healthy HTLV-III ser
Itamura S; Shigesada K; Imai M; Kobayashi N; Hamakado T; Harada T; Hatanaka M
An expression plasmid, pHY202, was constructed which directs the synthesis of a fusion protein encoded by the gag sequence of human T-cell leukemia virus type I (HTLV-I) inserted into the lacZ gene. Escherichia coli cells harboring pHY202 produced the 43-kDal LacZ -Gag fusion protein with a yield of approx. 0.3% of t
Although Epstein-Barr virus (EBV) was discovered in cultured Burkitt s lymphoma (BL) cells, its exact role remains unclear. Viral genome is found in 95-98% of endemic BL and 15-20% of non-endemic BL. Children destined to develop BL in Africa show elevated titres of viral capsid antibodies one to two years preceding em
Lazzarin A; Galli M; Geroldi D; Zanetti A; Crocchiolo P; Aiuti F; Moroni M
A clinico-epidemiological study is reported concerning a group of 306 parenteral drug addicts (PDAs), 71 of whom were affected with the lymphadenopathy syndrome (LAS); all were followed-up between 1981 and 1984. Although full-blown acquired immune deficiency syndrome (AIDS) was observed only in one case, none of the o
Int J Cancer. 1985 Dec 15;36(6):651-5. Unique Identifier : AIDSLINE MED/86058130
Robert-Guroff M; Clark J; Lanier AP; Beckman G; Melbye M; Ebbesen P; Blattner WA; Gallo RC
Sera of native inhabitants of Arctic regions were assayed for antibodies to HTLV-I by the ELISA technique followed by competition experiments to confirm antibody specificity. Residents of 7 widely separated Alaskan villages exhibited prevalence rates of 0 to 12% for HTLV-I antibodies. Less than 1% of
Int J Cancer. 1985 Dec 15;36(6):671-5. Unique Identifier : AIDSLINE MED/86058134
Hoshino H; Clapham PR; Weiss RA; Miyoshi I; Yoshida M; Miwa M
CCC/2M, CCC/10Y and CCC/MT-2 cat kidney cells producing Japanese isolates of human T-cell leukemia virus type I (HTLVs) and HOS/PL human osteosarcoma cells producing an American isolate of HTLV were infected with vesicular stomatitis virus (VSV) to prepare VSV pseudotypes bearing envelope antigens of HTLVs. VSV propag
MT-4 cells, which are a human T-cell lymphotropic virus type I (HTLV-I)-positive cell line highly permissive to HTLV-III infection, were used to detect the biologically active virus. For quantitation of the virus, induction of HTLV-III-specific antigen(s) and inhibition of DNA synthesis in infected MT-4 cells were ass
Okada M; Maeda M; Tagaya Y; Taniguchi Y; Teshigawara K; Yoshiki T; Diamantstein T; Smith KA; Uchiyama T; Honjo T; et al
Interleukin 2 (IL 2) receptor (IL 2-R) is constitutively expressed on T cell lines established from the patients with adult T cell leukemia (ATL), which is a human T cell leukemia lymphoma virus (HTLV-1)(+) T4(+)-leukemia endemic in Japan , the United Sta
Kaposi s sarcoma occurs as a complication in numerous cases of AIDS, the much-discussed acquired immune deficiency syndrome. Considering the latter s near-epidemic incidence, the clinical and histological features of Kaposi s sarcoma are recalled to mind. Hitherto only sporadically recorded in non-African countries, t
We report the first case of acquired immunodeficiency-syndrome (AIDS) with Kaposi s sarcoma which at the same time has also a changing biclonal gammopathy (initial: double IgG-paraproteinaemia, later on IgA-IgG double-paraproteinaemia) due to different lymphocyte clones. The relationship of a B-cell neoplasia to a con
A synthetic pentadecapeptide preparation, env 406-420, with an amino acid sequence deduced from the envelope glycoprotein gene of human T cell leukemia virus type I (HTLV I), was used as the antigen in an enzyme immunoassay for immunoglobulin G antibodies, exploring its usefulness for seroepidemiological purposes. The
The proteins of HTLV-I virus, the only human retrovirus implicated in the etiopathogenesis of the T-cell leukemia, were previously studied with the use of monoclonal antibodies. Different groups have produced specific monoclonal antibodies that recognized the core proteins of the virus p19 and p24 and in one case a mo
Ishida T; Yamamoto K; Ishimoto G; Shotake T; Takenaka O; Nozawa K; Hayami M; Hinuma Y
Asian nonhuman primates were surveyed seroepidemiologically for natural infection with human T-cell leukemia virus (ATLV/HTLV) or a closely related agent. Materials from various primates (three genera [Macaca, Presbytis, and Hylobates], 17 species, totalling 1,079 animals) under natural conditions were obtained in the
Med Microbiol Immunol (Berl). 1985;174(4):205-10. Unique Identifier : AIDSLINE MED/86065091
Abb J
Sera from 32 homosexual men were studied for the presence of antibodies against human T-lymphotropic virus type III (HTLV III) and acid-labile interferon (IFN) alpha. Infection with HTLV III was found to be associated with the presence of serum IFN. IFN was detected in 74% of sera from male homosexuals with HTLV III a
N Engl J Med. 1985 Dec 12;313(24):1493-7. Unique Identifier : AIDSLINE MED/86065314
Ho DD; Rota TR; Schooley RT; Kaplan JC; Allan JD; Groopman JE; Resnick L; Felsenstein D; Andrews CA; Hirsch MS
We conducted virus-isolation studies on 56 specimens from the nervous system of 45 patients in order to determine whether human T-cell lymphotropic virus Type III (HTLV-III) is directly involved in the pathogenesis of the neurologic disorders frequently encountered in the acquired immunodeficiency syndrome (AIDS) and
N Engl J Med. 1985 Dec 12;313(24):1498-504. Unique Identifier : AIDSLINE MED/86065315
Resnick L; diMarzo-Veronese F; Schupbach J; Tourtellotte WW; Ho DD; Muller F; Shapshak P; Vogt M; Groopman JE; Markham PD; et al
Intra-blood-brain-barrier production of virus-specific antibody is good evidence of infection within the blood-brain barrier. Patients with the acquired immuno-deficiency syndrome (AIDS) have an increased incidence of neurologic abnormalities--i.e., unexplained, diffuse encephalopathy manifested clinically as chronic
We conducted a study to identify the viruses in tissue specimens of oral hairy leukoplakia, a lesion that is found in immunosuppressed male homosexuals and that is associated with the subsequent development of the acquired immunodeficiency syndrome. When stained for papillomavirus core antigen, 49 of 67 biopsy specime
Nature. 1985 Dec 12-18;318(6046):571-4. Unique Identifier : AIDSLINE MED/86065489
Cann AJ; Rosenblatt JD; Wachsman W; Shah NP; Chen IS
Human T-cell leukaemia viruses (HTLVs) have genomic organization distinct from that of other replication-competent retroviruses, possessing four genes, gag, pol, env and chi. The unique fourth gene, chi (also referred to as lor), is located between env and the 3 long terminal repeat (LTR), encoding a protein of relat
Ratner L; Starcich B; Josephs SF; Hahn BH; Reddy EP; Livak KJ; Petteway SR Jr; Pearson ML; Haseltine WA; Arya SK; et al
The genome of the virus associated with the acquired immune deficiency syndrome (AIDS), human T-lymphotropic virus type III (HTLV-III), includes two open reading frames, not found in other retroviruses. One of these, designated 3 open reading frame (3 orf) is 648 base pairs (bp) in length, and overlaps with the 3 lo
Proc Natl Acad Sci U S A. 1985 Nov;82(22):7733-7. Unique Identifier : AIDSLINE MED/86067980
Ruprecht RM; Rossoni LD; Haseltine WA; Broder S
Retroviral propagation crucially depends on reverse transcriptase (RT). We have developed murine models to test the biological effectiveness of the RT inhibitor suramin. The drug was active in our assay system, which includes (i) inhibition of RT activity in the murine T-cell tropic virus SL3-3 and Rauscher murine leu
Proc Natl Acad Sci U S A. 1985 Dec;82(23):8198-202. Unique Identifier : AIDSLINE MED/86068069
Pahwa S; Pahwa R; Saxinger C; Gallo RC; Good RA
The etiologic agent for the acquired immunodeficiency syndrome (AIDS) is now firmly established as the retrovirus termed the human T-lymphotropic virus type III (HTLV-III) or the lymphadenopathy-associated virus, LAV. The disease is characterized by profound and progressive loss of immunity, but molecular evidence ind
The RNA-dependent DNA polymerase of the AIDS-associated retrovirus (ARV) gives highest activity with the synthetic template, poly(rA)oligo(dT) and prefers Mg2+ over Mn2+ as a divalent cation. It can use other template-primer combinations but with poly(rCm)oligo(dG), it prefers Mn2+ over Mg2+. Detection of ARV reverse
Levy JA; Shimabukuro J; McHugh T; Casavant C; Stites D; Oshiro L
We have examined the host range of AIDS-associated retroviruses (ARV) that are known to infect human T cells of the helper subset. We have observed that the virus cannot infect fibroblast and epithelial cell lines of many different animal species. It is infectious and replicates efficiently in peripheral mononuclear c
Human T-cell leukemia virus type I (HTLV-I) contains a unique gene pX coding for p40 chi, and this protein was suggested to activate the transcription from the LTR of HTLV. By a similar mechanism, this viral function might be involved in immortalization of T-cells and leukemogenesis in adult T-cell leukemia induced by
Z Rechtsmed. 1985;95(2):113-21. Unique Identifier : AIDSLINE MED/86072889
Puschel K; Tenner-Racz K; Racz P; Dietrich M; Kern P; Schmitz H; Lieske K
The registration of patients with acquired immune deficiency syndrome (AIDS) and AIDS deaths is centralized for medical research. A short review of the epidemiological state of AIDS in Hamburg is given (situation as of February 1985), and the autopsy results of seven postmortem examinations are referred to. Kaposi s s
Cell surface markers were determined in 10 patients with chronic lymphocytic leukemia (CLL) in Jamaica , an area endemic for the human T-cell leukemia/lymphoma virus (HTLV-I) and with a high positivity for HTLV-I antibody titers in CLL patients. The results demonstrated that the pr
Ohtsuki Y; Miyoshi I; Taguchi H; Takeda I; Akagi T
The cross-reactivity of antibodies to adult T-cell leukemia (ATL)-associated antigens (ATLA) in human and monkey sera was investigated by indirect immunoperoxidase and immunoferritin methods using a human cell line (MT-2) carrying a type C virus (HTLV), two monkey cell lines (Si-1 and Si-3) carrying HTLV, and a monkey
One hundred four cases of malignant lymphomas, including 90 cases of non-Hodgkin s lymphoma , 5 cases of histiocytic malignancy, and 9 cases of Hodgkin s disease were analyzed pathologically and immunologically using a panel of monoclonal and conventional antibodies for T-, B-, hist
From 1980 to 1984, a total of 3,978 serum samples were collected from healthy subjects in the Yaeyama District of Okinawa, Japan . These serum samples were tested for presence of antibody to adult T-cell leukemia-associated antigen (anti-ATLA) by the enzyme-linked immunosorbent assay
Ann Intern Med. 1986 Jan;104(1):41-4. Unique Identifier : AIDSLINE MED/86075434
Masur H; Lane HC; Palestine A; Smith PD; Manischewitz J; Stevens G; Fujikawa L; Macher AM; Nussenblatt R; Baird B; et al
Eight immunosuppressed homosexual men with cytomegalovirus viremia--seven with serious bilateral retinitis, one with colitis in addition to retinitis, and one with pneumonitis only--were treated with a new acyclovir derivative, 9-(1,3-dihydro
In 35 homosexual men with isolated thrombocytopenia at initial presentation, who were evaluated and treated between 1982 and 1984, hematologic studies showed immune destruction. In contrast to findings in other autoimmune conditions, T-lymphocyte subsets in these patients were reversed, with a mean helper to suppresso
Neurological complications occurred in 6 children, aged 6 months to 5 years, with acquired immune deficiency syndrome who were followed for 14 months. The most frequent manifestations included encephalopathies, acquired microcephaly, and pyramidal tract signs. Computed tomographic examinations showed variable degrees
Ann Neurol. 1985 Nov;18(5):611-4. Unique Identifier : AIDSLINE MED/86075842
Dix RD; Bredesen DE; Erlich KS; Mills J
Over a one-year period the cerebrospinal fluid (CSF) obtained from a series of homosexual men immunocompromised with either Hodgkin s disease or acquired immune deficiency syndrome (AIDS) was cultured to assess the frequency with which infectious viruses could be recovered. Of 58 patients examined, 4 (6.9%) had CSF cu
Human T-cell lymphotropic virus type I-associated adult T-cell leukemia/lymphoma is a newly described clinical entity characterized by the abrupt onset of cutaneous manifestations, hypercalcemia, lymphadenopathy, and pleomorphic lobulated T cells found in the peripheral blood. The vast majority of cases reported in th
Cytomegalovirus ( CMV ) infection involving multiple organ systems is a common finding in the acquired immunodeficiency syndrome. Acute CMV neuritis was a complication in two patients with acquired immunodeficiency syndrome. The diagnosis was made in both patients
Interleukin 2 (IL 2) is a central mediator of the growth and functional activity of B- and T-cells, and cytotoxic cells, including Natural Killer and Lymphokine Activated Killer cells. Significant defects in the production of, and response to, IL 2 have been described in a variety of congenital and acquired immunodefi
Annu Rev Immunol. 1985;3:477-500. Unique Identifier : AIDSLINE MED/86051001
Lane HC; Fauci AS
The immune systems of patients with AIDS are characterized by a profound defect in cell-mediated immunity which is predominantly due to a decrease in the number and function of the helper/inducer T lymphocytes, particularly the antigen-reactive cells. This defect is manifested primarily as decreases in delayed-type hy
Maeda M; Shimizu A; Ikuta K; Okamoto H; Kashihara M; Uchiyama T; Honjo T; Yodoi J
Using the clone-specific rearrangement of the T cell receptor gene as the genetic marker of the clonotype, we analyzed the clonal origin of the interleukin 2 ( IL-2 )-dependent human T-lymphotrophic virus I (HTLV-I)-positive T cell lines established from various adult T
Acute encephalopathy was associated with the appearance of antibodies to human T-lymphotropic virus (HTLV-III) in two patients. A third patient showed seroconversion for anti-HTLV-III, but the temporal association was not established so precisely. The illness was characterised by a prodromal period of up to 2 weeks, c
Human Participants in Research and Committee on Gay Concerns Available from the Scientific Affairs Office, American Psychological Association, 1200 17th Street, N.W., Washington, D.C. 20036, 1985 Sep 11 p Unique Identifier : AIDSLINE KIE/19801
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