Neuropathologic findings in the acquired immunodeficiency syndrome (AIDS). NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Neuropathologic findings in the acquired immunodeficiency syndrome (AIDS).

Clin Neuropathol. 1986 Jan-Feb;5(1):1-20. Unique Identifier : AIDSLINE MED/86134315
Anders K; Steinsapir KD; Iverson DJ; Glasgow BJ; Layfield LJ; Brown WJ; Cancilla PA; Verity MA; Vinters HV

Abstract: The acquired immunodeficiency syndrome (AIDS) is characterized by a severe idiopathic deficiency in T-cell mediated immunity. Homosexuals, intravenous drug abusers and Haitians are predominantly affected, predisposing them to opportunistic infections and neoplasms. In this study, the central nervous system (CNS) was examined at autopsy in 29 AIDS patients. Significant CNS complications occurred in 55%, mainly related to opportunistic infections similar to those seen in patients with other causes of immunosuppression. Progressive multifocal leukoencephalopathy (three cases), cytomegalovirus (CMV) encephalitis (five cases), cryptococcal meningitis (four cases), Mycobacterium avium-intracellulare (three cases), and toxoplasmosis (one case) were found. Widespread microglial nodules were observed in 20 patients, 80% of whom had CMV inclusions elsewhere at autopsy. Primary cerebral lymphoma (one case) and lymphomatoid granulomatosis (one case) were present. Subarachnoid (five cases) and intraparenchymal (three cases) hemorrhage was seen although these were not usually clinically significant. A single case of embolic arterial obstruction with cortical infarction was due to non-bacterial thrombotic endocarditis.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/PATHOLOGY Adult Brain/*PATHOLOGY Brain Diseases/*COMPLICATIONS Human Lymphoma/COMPLICATIONS Lymphomatoid Granulomatosis/COMPLICATIONS Male Middle Age Mycoses/COMPLICATIONS Protozoan Infections/COMPLICATIONS Sarcoma, Kaposi's/COMPLICATIONS Support, Non-U.S. Gov't Virus Diseases/COMPLICATIONS JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplications/pathologyadultbrain/KWDpathologybraindiseases/KWDcomplicationshumanlymphoma/complicationslymphomatoidgranulomatosis/complicationsmalemiddleagemycoses/complicationsprotozoaninfections/complicationssarcoma,kaposi's/complicationssupport,non-uKWDsKWDgov'tvirusdiseases/complicationsjournalarticle
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M8660210

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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