The expression of endothelial cell surface antigens by AIDS-associated Kaposi's sarcoma. Evidence for a vascular endothelial cell origin. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


The expression of endothelial cell surface antigens by AIDS-associated Kaposi's sarcoma. Evidence for a vascular endothelial cell origin.

Am J Pathol. 1986 Mar;122(3):493-9. Unique Identifier : AIDSLINE MED/86156112
Rutgers JL; Wieczorek R; Bonetti F; Kaplan KL; Posnett DN; Friedman-Kien AE; Knowles DM 2d

Abstract: The authors investigated 19 cases of Kaposi's sarcoma (KS) obtained from patients with the acquired immune deficiency syndrome (AIDS) for their expression of Factor VIII-related antigen (FVIIIRAg), HLA-DR (Ia) antigens, OKM1, and three distinctive vascular, but not lymphatic, endothelial-cell-associated antigens, E92, OKM5, and HCl. Antigen expression was demonstrated by immunoperoxidase staining of cryostat sections. FVIIIRAg is strongly expressed by the cells lining the vascular spaces (VCs) but is absent, weakly or focally, and variably expressed by the spindle cell (SC) component of KS. The VC component of each KS lesion examined strongly expressed E92, moderately expressed HCl, and weakly expressed OKM5. In contrast, the entire SC component of each KS lesion studied strongly expressed E92 and OKM5 and weakly expressed HCl. Neither the VCs nor the SCs expressed OKM1. These studies provide strong and compelling evidence for the vascular endothelial cell histogenesis of both the vascular and spindle cell components of KS, demonstrate the intertumor and intratumor phenotypic heterogeneity of KS, and suggest that monoclonal antibodies OKM5 and anti-E92 are the best currently available immunohistochemical markers for identifying the spindle cell component of AIDS-associated KS in cryostat sections.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Antigens, Neoplasm/*ANALYSIS Antigens, Surface/*ANALYSIS Blood Vessels/IMMUNOLOGY/PATHOLOGY Endothelium/IMMUNOLOGY/PATHOLOGY Histocytochemistry Human Immunochemistry *Lymph Nodes Lymphatic Diseases/COMPLICATIONS/*IMMUNOLOGY/PATHOLOGY Neoplasms Sarcoma, Kaposi's/COMPLICATIONS/*IMMUNOLOGY/PATHOLOGY Skin Neoplasms/COMPLICATIONS/*IMMUNOLOGY/PATHOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsantigens,neoplasm/KWDanalysisantigens,surface/KWDanalysisbloodvessels/immunology/pathologyendothelium/immunology/pathologyhistocytochemistryhumanimmunochemistryKWDlymphnodeslymphaticdiseases/complications/KWDimmunology/pathologyneoplasmssarcoma,kaposi's/complications/KWDimmunology/pathologyskinneoplasms/complications/KWDimmunology/pathologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
860630
M8660191

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1986. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1986. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .