Pentamidine-induced hypoglycemia in patients with the acquired immune deficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Pentamidine-induced hypoglycemia in patients with the acquired immune deficiency syndrome.

Clin Pharmacol Ther. 1986 Mar;39(3):271-5. Unique Identifier : AIDSLINE MED/86134389
Stahl-Bayliss CM; Kalman CM; Laskin OL

Abstract: We conducted an analysis of 37 patients with the acquired immune deficiency syndrome (AIDS) who received pentamidine for the treatment of Pneumocystis carinii pneumonia to quantitate the incidence and severity of pentamidine-induced hypoglycemia. Ten of these patients (27%), nine of whom were symptomatic, developed hypoglycemia during or shortly after pentamidine therapy. The mean nadir blood glucose concentration in those who developed hypoglycemia during or shortly after pentamidine therapy was 38 mg/dl (range 20 to 55 mg/dl). The hypoglycemia frequently persisted after the end of pentamidine therapy. The incidence of nephrotoxicity in patients who developed hypoglycemia was 100%, as compared with 38% in the group who remained euglycemic (P less than 0.01). The overall incidence of pentamidine-induced hypoglycemia with AIDS is several-fold higher than previously reported for patients with other immunocompromising diseases who receive pentamidine. We conclude that pentamidine-induced hypoglycemia is a frequent adverse reaction in patients with AIDS and is potentially life-threatening if not recognized.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Amidines/*ADVERSE EFFECTS Blood Glucose Female Human Hypoglycemia/*CHEMICALLY INDUCED Infant Infusions, Parenteral Kidney Diseases/*CHEMICALLY INDUCED Male Medical Records Middle Age Pentamidine/*ADVERSE EFFECTS/THERAPEUTIC USE Pneumonia, Pneumocystis carinii/*COMPLICATIONS/DRUG THERAPY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsadultamidines/KWDadverseeffectsbloodglucosefemalehumanhypoglycemia/KWDchemicallyinducedinfantinfusions,parenteralkidneydiseases/KWDchemicallyinducedmalemedicalrecordsmiddleagepentamidine/KWDadverseeffects/therapeuticusepneumonia,pneumocystiscarinii/KWDcomplications/drugtherapysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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