Phase II studies using alpha-2 interferon (INTRON) for treatment of nonhematologic malignancies are discussed. Results with INTRON as well as with other interferon products have generally been negative in most adult solid tumors (eg, breast, colon, and lung); most studies were conducted in patients with advanced disea
Cancer - Principles and Practice of Oncology. 2nd Edition. DeVita VT Jr, Hellman S, Rosenberg SA, eds. Philadelphia, Lippincott, p. 1623-709, 1985.. Unique Identifier : AIDSLINE ICDB/86620340
Hodgkin s disease and the non-Hodgkin s lymphomas are reviewed under the following headings: etiology and epidemiology, microscopic anatomy of normal lymphoid tissues (lymphoreticular cell surface markers; identification of lymphoreticular cells with monoclonal antibodies), cellular origin of the lymphomas (pathology
Cancer - Principles and Practice of Oncology. 2nd Edition. DeVita VT Jr, Hellman S, Rosenberg SA, eds. Philadelphia, Lippincott, p. 1963-98, 1985.. Unique Identifier : AIDSLINE ICDB/86620354
Infections in the cancer patient (pt) are discussed with respect to impaired host defense (integumentary and mucosal barriers; phagocytic defenses; cellular and humoral immunity; reticulodendothelial system and splenectomy; nutrition; exogenous and endogenous microbial flora; acquired immunodeficieny syndrome), initia
Cancer - Principles and Practice of Oncology. 2nd Edition. DeVita VT Jr, Hellman S, Rosenberg SA, eds. Philadelphia, Lippincott, p. 1999-2006, 1985.. Unique Identifier : AIDSLINE ICDB/86620355
Blattner WA; Hoover RN; Family Studies Section, Environmental Epidemiology Branch, Div.; of Cancer Etiology, NCI, Bethesda, MD
Congenital immune deficiency, drug-induced immunodeficiency, clinical conditions associated with altered immunity, and acquired immunodeficiency syndrome (AIDS) are each reviewed with respect to development of malignancies. Fourteen naturally occurring, genetically determined immunodeficiency diseases have been define
Two cases of reactive hemophagocytic syndrome (RHS) are reported, and the clinical and pathological features are compared with other histiocytic proliferative disorders, including familial hemophagocytic lymphohistiocytosis (FHL) and malignant histiocytosis. RHS can be associated with a variety of infections, includin
The incidence rate of acquired syphilis per 100 000 total population in Denmark increased by 70% from 6.8 in 1978 to 11.6 in 1982. In 1984 this incidence had decreased by 61.2% to 4.5. The fluctuation of the number of acquired syphi
We studied 26 cases of digestive manifestation in AIDS. The 26 patients were divided into two different epidemiological groups: 13 homosexual men, constituted the first group; no homosexual patient was in the second group which included 6 haitians, 6 africans and a pakistanian. The clinical manifestation were: a water
Pediatr Med Chir. 1985 Mar-Apr;7(2):181-8. Unique Identifier : AIDSLINE MED/86148695
Nespoli L; Arico M; Burgio VL
Histiocytosis is the term currently used to describe the group of diseases characterized by activation and proliferation of monocytic-mononuclear cells. Some of these are reactive to well-known causes, mycobacteriae, viral and parasitic infections, or chronic storage of minerals. Wider and more intriguing is the group
Ann N Y Acad Sci. 1985;459:67-72. Unique Identifier : AIDSLINE MED/86157298
Greenberg ML; Siegal FP
In AIDS, although there is a lack of humoral responsiveness in vitro and in vivo, many patients persistently have an increased number of B cells which continue to produce increased amounts of immunoglobulin. An objective, reproducible morphologic classification scheme for B cells was devised. Comparison of cell kineti
Can J Psychiatry. 1986 Feb;31(1):63-5. Unique Identifier : AIDSLINE MED/86133085
Lippert GP
The Acquired Immune Deficiency Syndrome (AIDS) has become an increasingly common cause of severe morbidity and death among homosexual men. As such it has become a major source of concern to this group. In this paper I report the cases of two bisexual men who developed a severe illness characterized by fatigue, malaise
Cunnion RE; Schaer GL; Parker MM; Natanson C; Parrillo JE
Reversible myocardial depression, manifested by ventricular dilatation and decreased ejection fraction, is common in human septic shock. A proposed mechanism, based on animal studies, is myocardial ischemia resulting from inadequate coronary blood flow. Coronary flow observations have not been reported for human septi
Anders K; Steinsapir KD; Iverson DJ; Glasgow BJ; Layfield LJ; Brown WJ; Cancilla PA; Verity MA; Vinters HV
The acquired immunodeficiency syndrome (AIDS) is characterized by a severe idiopathic deficiency in T-cell mediated immunity. Homosexuals, intravenous drug abusers and Haitians are predominantly affected, predisposing them to opportunistic infections and neoplasms. In this study, the central nervous system (CNS) was e
FEBS Lett. 1986 Feb 17;196(2):301-4. Unique Identifier : AIDSLINE MED/86136537
Tsujimoto A; Tsujimoto H; Yanaihara N; Abe K; Hayami M; Miwa M; Shimotohno K
The gene product of the X region was examined in simian lymphoid cell lines producing simian T-cell leukemia virus (STLV), which is closely related to human T-cell leukemia virus (HTLV). By use of specific antibodies against pX peptides of HTLV-I, a protein of 41 kDa was identified as a pX product of STLV.
Cryptosporidium is a parasite of the human gastrointestinal tract and has a worldwide distribution. We developed a sensitive and reproducible enzyme immunoassay for detection of serum IgG or IgM to Cryptosporidium. For IgG, 13 of 15 patients with cryptosporidiosis and 26 of 26 patients with cryptosporidiosis and AIDS
As is evident from the foregoing discussion, hepatitis A and hepatitis B are not static, passe disease. Knowledge concerning these illnesses continues to expand at a fantastic rate--all of it of extreme practical clinical significance. Most interesting is the elucidation of the etiology of the acquired immune deficien
AIDS is a lethal infectious disease that must certainly be dealt with carefully, but through conscientious application of well-established procedures and techniques, health care professionals may provide the best possible care to the patients suffering the ravages of this disease without undue risk to themselves or th
Nyberg DA; Jeffrey RB Jr; Federle MP; Bottles K; Abrams DI
Recent evidence indicates that individuals with acquired immunodeficiency syndrome (AIDS) or those at high risk for AIDS have an increased occurrence of lymphoma. AIDS-related lymphomas (ARLs) often present with an advanced stage of disease and highly malignant histologic subtypes. This study reviewed the abdominal co
Jurkiewicz E; Nakamura H; Schneider J; Yamamoto N; Hayami M; Hunsmann G
Core polypeptides of primate lymphotropic retroviruses (PLRV) have very similar molecular weights. To discriminate between individual PLRVs we have compared two-dimensional tryptic peptide maps of 125I-labeled core polypeptides p19 and p24 of 11 isolates originating from humans and six simian species. Peptide maps sho
The authors investigated 19 cases of Kaposi s sarcoma (KS) obtained from patients with the acquired immune deficiency syndrome (AIDS) for their expression of Factor VIII-related antigen (FVIIIRAg), HLA-DR (Ia) antigens, OKM1, and three distinctive vascular, but not lymphatic, endothelial-cell-associated antigens, E92,
Ann Thorac Surg. 1986 Mar;41(3):307-12. Unique Identifier : AIDSLINE MED/86157900
Pass HI; Potter D; Shelhammer J; Macher A; Ognibene FP; Longo DL; Gelmann E; Masur H; Roth JA
Pulmonary infiltrates in the patient with acquired immunodeficiency syndrome (AIDS) may be associated with a spectrum of unusual neoplastic and infectious process. Transbronchial biopsy frequently reveals the cause of these infiltrates; however, when transbronchial biopsy is nondiagnostic or contraindicated, or if the
Ocular toxoplasmosis typically presents as a focal necrotizing retinochoroiditis. We report a case of diffuse necrotizing retinochoroiditis due to toxoplasmosis in a patient with the acquired immunodeficiency syndrome (AIDS). The appearance at initial presentation was similar to the acute retinal necrosis syndrome. We
We report a case of a moderately disseminated, slowly progressing Kaposi s sarcoma, with a primary cutaneous nodule on the glans penis. The multifocal skin tumor appeared in a 44-year-old bisexual man and was not associated with acquired immunodeficiency syndrome.
Archibald DW; Zon L; Groopman JE; McLane MF; Essex M
Whole saliva samples collected from available people at risk in Boston for infection with human T-lymphotropic virus type III (HTLV-III/LAV), from late 1984 through early 1985, were analyzed for the presence of antibodies to viral proteins. Fourteen of 20 (70%) acquired immunodeficiency syndrome (AIDS) patients and 14
Monocyte-mediated functions were evaluated in the peripheral blood mononuclear cells (PBMC) of 11 previously untreated patients with Kaposi s sarcoma in association with the acquired immune deficiency syndrome (KS/AIDS). All patients had lymphadenopathy, an abnormal OKT.4/OKT.8 ratio, and a good performance status; no
We conducted an analysis of 37 patients with the acquired immune deficiency syndrome (AIDS) who received pentamidine for the treatment of Pneumocystis carinii pneumonia to quantitate the incidence and severity of pentamidine-induced hypoglycemia. Ten of these patients (27%), nine of whom were symptomatic, developed hy
Silverman S Jr; Migliorati CA; Lozada-Nur F; Greenspan D; Conant MA
A total of 375 homosexual males were studied to assess the dental findings, life-style, and risk factors during a 4-year period. At baseline, 136 of the patients were diagnosed as having AIDS, 116 were considered at risk for AIDS, and 123 were considered healthy. In a mean follow-up time of 23 months, nine of the pati
Ann Intern Med. 1986 Apr;104(4):511-4. Unique Identifier : AIDSLINE MED/86157217
Whimbey E; Gold JW; Polsky B; Dryjanski J; Hawkins C; Blevins A; Brannon P; Kiehn TE; Brown AE; Armstrong D
Forty-nine episodes of bacteremia and fungemia occurred in 38 of 336 patients with the acquired immunodeficiency syndrome seen at our institution since 1980. There were five types of infections. Infections commonly associated with a T-cell immunodeficiency disorder comprised 16 episodes and included those with Salmone
Kaposi s sarcoma is a neoplasm that is usually malignant and occurs in the skin and sometimes in the lymph nodes and internal organs. The cause is unknown, but recently it has become epidemic because of its involvement in acquired immune deficiency syndrome (AIDS). Although it is worldwide in distribution, the disease
Weiske R; Buck J; Schneider R; Hannemann T; Krauss B
A short description of epidemiologic and clinical facts correlated with the acquired immunodeficiency syndrome (AIDS) is followed by a report on the manifestation of pulmonary infections mostly effected by Pneumocystis carinii. Two examples out of four cases will demonstrate the radiographic appearance of the Pneumocy
Inoue J; Watanabe T; Sato M; Oda A; Toyoshima K; Yoshida M; Seiki M
A provirus clone of simian T-cell leukemia virus isolated from a pigtailed monkey (PT-STLV), which is 90% homologous to HTLV-I, was shown to be biologically active in transfection assay. In transfected cells, gp61env, Pr55gag, and the mature gag proteins p24, p21, and p15 were detected, and type C particles were produ
Ragni MV; Tegtmeier GE; Levy JA; Kaminsky LS; Lewis JH; Spero JA; Bontempo FA; Handwerk-Leber C; Bayer WL; Zimmerman DH; et al
Antibodies to the AIDS retrovirus, specifically to human T cell lymphotropic virus, type III, and AIDS-associated retrovirus, were detected with increasing prevalence in a population of 190 hemophiliacs from western Pennsylvania between 1981 and 1984: 7.7% in 1981, 20.0% in 1982, 45.5% in 1983, and 62.5% in 1984. The
Taylor J; Afrasiabi R; Fahey JL; Korns E; Weaver M; Mitsuysau R
Sixteen immunological parameters were assessed quantitatively for their value in providing an immunologically-based and prognostically significant classification of the immune alteration in 97 patients with AIDS and Kaposi s sarcoma (AIDS-KS). The dimensions of reductions in the T4 (T helper-inducer cells) subpopulati
Br Med J (Clin Res Ed). 1986 Feb 22;292(6519):527-9. Unique Identifier : AIDSLINE MED/86132501
Robertson JR; Bucknall AB; Welsby PD; Roberts JJ; Inglis JM; Peutherer JF; Brettle RP
Stored blood samples from 164 intravenous drug abusers who attended a Scottish general practice were tested for HTLV-III/LAV (human T cell lymphotropic virus type III/lymphadenopathy associated virus) infection. Of those tested, 83 (51%) were seropositive, which is well above the prevalence reported elsewhere in Brita
Kaposi s sarcoma (KS) in acquired immune deficiency syndrome (AIDS) is a new manifestation of a previously rare disease, and generally has a fatal course. Variations in the clinical course and in response to treatment by patients with this disease suggest that specific immunologic or clinical parameters may be importa
Krown SE; Real FX; Vadhan-Raj S; Cunningham-Rundles S; Krim M; Wong G; Oettgen HF
Interferon alfa-2a (Roferon-A, Hoffmann-La Roche Inc., Nutley, NJ) was used to treat sequential groups of patients with Kaposi s sarcoma associated with the acquired immune deficiency syndrome (AIDS). Major antitumor effects (complete or partial responses) were observed in 38% o
We have used the novel monoclonal antibodies 9.3 and anti-Leu-8 in conjunction with other T cell markers to quantify T cell subpopulations in the paracortex, mantle, and germinal center compartments of frozen sections of lymph nodes from seven homosexual men with acquired immunodeficiency syndrome (AIDS) and five hete
By means of the Central Card Index of Haemophilia, a working material of the Section of Haemophilia in the Society of Haematology and Blood Transfusion of the GDR, 52 patients with heriditary haemorrhagic diatheses could be registered. These persons had died between 1962 and 1984. The average age of death amounted to
We studied twenty-five skin biopsies from twenty-one patients with acquired immunodeficiency syndrome or its prodrome who presented with the seborrheic dermatitis associated with acquired immunodeficiency syndrome and compared them with an equal number of biopsies from patients with seborrheic dermatitis who had neith
Acquired immunodeficiency syndrome (AIDS) has reached epidemic proportions throughout the world. Because at least 40% of AIDS victims are neurologically symptomatic, the neuroscience nurse must be prepared to care for increasing numbers of these patients. This article will define the syndrome, identify risk groups, an
Immunological and mycological investigations were carried out in 21 Swedish homosexual males. One of them had AIDS, one pre-AIDS and 19 lymphadenopathy of whom 18 fulfilled the criteria of persistent generalized lymphadenopathy (PGL) as defined by the Centers for Disease Control, Atlanta, (CDC). The patients were inve
Skin biopsies from a subject affected by KS and AIDS were examined by means of EM. Samples were obtained both in correspondence of a typical nodule, and from an apparently normal area. The disease process had started at least 8 mo. before, and the patient showed a reduced number of OKT4 cells, with an inversion of the
Boll Ist Sieroter Milan. 1985;64(5):363-6. Unique Identifier : AIDSLINE MED/86131153
Anti-HTLV III had been detected in 12,689 serum samples collected within August 1985 from 12 Transfusion Centres of Liguria. In the course of the first test, carried out by ELISA using disrupted virions as antigen, 12,666 samples (99.81%) resulted non reactive; 14 (0.1%) belonged to the grey-zone and 9 (0.08%) were cl
Boll Ist Sieroter Milan. 1985;64(5):367-70. Unique Identifier : AIDSLINE MED/86131154
Crovari P; Cassini U; Infante D; Guano F; Icardi GC; Auteri G; Di Ponzio A; Cuneo Crovari P
Prevalence of positive subjects to anti-HTLV III and HBV markers (HBsAg; anti-HBc; anti-HBs) has been studied both among jailed people and wardens of Sanremo Jail. Out of 92 subjects in custody, 11 were anti-HTLV III positive and 44 had acquired HBV infection markers (antigen and/or antibodies). One of the wardens res
This study deals with the immunohistochemistry of a monoclonal antibody (Mab) raised against the p18 protein of the LAV virus in lymphnodes from 20 cases of persistent generalized lymphoadenopathy (PGL) (2) and 6 of acquired immunodeficiency syndrome (AIDS) (3). In all the PGL cases that have been studied, we observed
Lymphoma occurs at increased frequency in patients with the acquired immunodeficiency syndrome (AIDS). We studied, using serologic and molecular techniques, one such lymphoma for (a) evidence of infection with human T lymphotropic virus, type III (HTLV-III), and Epstein-Barr virus (EBV), (b) monoclonal rearrangement o
Cell lines were established from five patients with T cell malignancies. Two patients had T cell lymphoblastic lymphoma (T-LL), whereas three patients had T cell acute lymphoblastic leukemia (T-ALL). Both T-LL cell lines expressed cell surface antigens characteristic of midthymocytes (Leu 2, 3, 6+). One T-ALL cell lin
Farthing CF; Henry K; Shanson DC; Taube M; Lawrence AG; Harcourt-Webster JN; Gazzard B
The findings of 27 lymph node biopsies performed on 24 homosexual patients with lymphadenopathy are presented. Six had acquired immune deficiency syndrome (AIDS) and 18 lymphadenopathy only, of whom one subsequently developed AIDS. All these patients had antibodies to the human T-cell lymphotropic virus type III (HTLV
Rashleigh-Belcher HJ; Carne CA; Weller IV; Smith AM; Russell RC
Lymph node biopsy was performed in 39 homosexual men with unexplained persistent generalized lymphadenopathy (PGL). Thirty-seven (95 per cent) of these patients had antibodies to human T-lymphotropic virus type III (HTLV-III), at the time of biopsy. Histology in all but one showed only follicular hyperplasia, the exce
Scott HJ; Glynn MJ; Lane IF; Anderson MG; Theodorou NA; Murray-Lyon IM; Reynolds KW
Since January 1985 we have changed our policy regarding lymph node biopsy in male homosexuals presenting with lymphadenopathy. Before that date all such patients underwent biopsy if there was no apparent cause. We no longer perform biopsy in male homosexuals presenting with uncomplicated persistent generalized lymphad
Br Med J (Clin Res Ed). 1986 Jan 25;292(6515):228-30. Unique Identifier : AIDSLINE MED/86132422
Lange JM; Coutinho RA; Krone WJ; Verdonck LF; Danner SA; van der Noordaa J; Goudsmit J
Longitudinal IgG recognition patterns of viral proteins were studied in 15 men who had seroconverted for lymphadenopathy associated virus/human T lymphotropic virus (LAV/HTLV-III). Antibodies to the major viral core protein p24, which is a cleavage product of the gag gene encoded precursor protein pr55, appeared first
Earlier reported findings of hepatitis B virus (HBV) DNA in white blood cells of patients with hepatoma, and in a patient with autoimmune haemolytic anaemia, led to the examination of HBV DNA in a series of twenty three patients with acquired immune deficiency syndrome (AIDS), including nine with opportunistic infecti
Antibodies against HTLV-III, neopterin levels in blood and urine, TH/TS ratio and hepatitis marker were determined in 34 clinically symptom-free persons known to be intravenous drug abusers. 15 persons were positive in the ELISA and Western-blot tests. There was a strong reaction to protein p24 compared with that to p
Anti-HTLV-III antibody was tested in frozen sera from high-risk individuals, collected between 1974 and 1985 in Switzerland . All but one of the 262 sera of a control group were negative. Among drug addicts, none of the 78 samples collected from 1974 to 1979 was positive. Antib
FEBS Lett. 1986 Mar 3;197(1-2):84-8. Unique Identifier : AIDSLINE MED/86136607
Chandra A; Gerber T; Chandra P
The reverse transcriptase from AIDS virus, HTLV-III, was purified and characterized. The purified enzyme has a very high affinity for template primers (rC)n X (dG)12 and (rCm)n X (dG)12 compared to that for (rA)n X (dT)12. In addition, the HTLV-III reverse transcriptase was able to transcribe (rAm)n X (dT)12 very effi
Sharer LR; Epstein LG; Cho ES; Joshi VV; Meyenhofer MF; Rankin LF; Petito CK
The neuropathologic findings in 11 children with a new CNS disorder that occurs in children with the acquired immunodeficiency syndrome (AIDS) and is postulated to be due to LAV/HTLV-III, the virus that causes AIDS, are reported. The children, who ranged in age from 4 months to 11 years, died of AIDS complicated by pr
Coutinho RA; Krone WJ; Smit L; Albrecht-van Lent P; van der Noordaa J; Schaesberg W; Goudsmit J
To establish when lymphadenopathy associated virus or human T lymphotropic virus (LAV/HTLV-III) was introduced into the Netherlands , we studied a cohort of homosexual men who participated in a hepatitis B vaccine efficacy study between 1980 and 1982. On entry into the study (N
Immunol Lett. 1985;11(5-6):305-10. Unique Identifier : AIDSLINE MED/86138451
Hollan SR; Fust G; Nagy K; Horvath A; Krall G; Verebelyi K; Ujhelyi E; Varga L; Mayer V
Hungary can be considered as a low risk area for AIDS since no patient with full-blown AIDS or AIDS-related complex has been found in the country. A complex clinical and immunological (T cell subsets, DNCB sensitization test, circul
Int J Cancer. 1986 Mar 15;37(3):335-41. Unique Identifier : AIDSLINE MED/86138741
Tamura K; Nagamine N; Araki Y; Seita M; Okayama A; Kawano K; Tachibana N; Tsuda K; Kuroki Y; Narita H; et al
The clinical characteristics of 33 patients with adult T-cell leukemia (ATL) are described. All patients were born and have lived in Miyazaki Prefecture (southwest of Japan ). Because of a wide range of clinical presentations and courses, they were subdivided into 2 groups. In the hi
Int J Cancer. 1986 Mar 15;37(3):395-400. Unique Identifier : AIDSLINE MED/86138749
Sato H; Okochi K
Human T-cell clones bearing antigens encoded by human T-cell leukemia/lymphoma virus (HTLV-I) were isolated from 6 patients who produced antibodies against HTLV-I after having received anti-HTLV-I-positive blood units containing cell components. On the other hand, it was not possible to isolate clonal cells carrying v
Int J Cancer. 1986 Mar 15;37(3):451-7. Unique Identifier : AIDSLINE MED/86138756
Balzarini J; Mitsuya H; De Clercq E; Broder S
Suramin and various other selected compounds were evaluated for their in vitro inhibitory effects on the infectivity and replication of human T-cell lymphotropic virus (HTLV/III)/lymphadenopathy-associated virus (LAV). As parameters for infectivity and replication, respectively, we followed the cytopathic effect of HT
Retroviruses have a genomic RNA and can induce malignant tumors. Study of the retroviruses led to the discovery of retroviral oncogenes, which were found to be responsible for the development of malignancies. Later on, cellular genes were detected that are closely related to the viral oncogenes but not oncogenic per s
Seiki M; Inoue J; Takeda T; Hikikoshi A; Sato M; Yoshida M
Human T-cell leukemia virus type I has a unique sequence pX and the product p40x was proposed to be a specific trans-acting transcriptional activator of expression of the viral gene. Recently, a second pX protein p27x-III in addition to p40x was identified; these two proteins are encoded by overlapping frames III and
Ootsuyama Y; Shimotohno K; Miwa M; Oroszlan S; Sugimura T
We found that p19gag of HTLV-I and p23gag of HTLV-II are myristylated. The p28, which is immunologically cross-reactive with monoclonal antibody against p19gag of HTLV-I was also shown to be myristylated in the HTLV-I-infected cell lines MT-2 and HUT102. However, no myristylated p28 was found in HTLV-II-infected cell
Kinoshita K; Yamanouchi K; Ikeda S; Momita S; Amagasaki T; Soda H; Ichimaru M; Moriuchi R; Katamine S; Miyamoto T; et al
To obtain definitive evidence that milk-borne infection plays a critical role in the endemy or mother-to-child transmission of human T-cell leukemia virus type-I (HTLV-I), we inoculated concentrated fresh human milk cells obtained from HTLV-I carrier mothers into the oral cavity of a common marmoset (Callithrix jacchu
Collins JM; Klecker RW Jr; Yarchoan R; Lane HC; Fauci AS; Redfield RR; Broder S; Myers CE
Suramin has been reported to inhibit the reverse transcriptase activity of a number of retroviruses and to reduce the in vitro infectivity and cytopathic effect of HTLV-III/LAV, the etiologic agent of acquired immune deficiency syndrome (AIDS). The clinical pharmacokinetics of suramin were investigated as part of a pi
A 32-year-old male homosexual presented to the emergency department (ED) with the clinical picture of a nonspecific illness. While in the ED, he experienced a first-time seizure. Computed tomography (CT) showed an enhancing mass lesion. Antibacterial therapy was started and continued until a second lumbar puncture (LP
To study the human host response to viral structural proteins during HTLV type I infection, five synthetic peptides matching the N-terminal and C-terminal regions of HTLVI p19 core protein were used to identify antigenic sites on p19 that were immunogenic in man. In radioimmunoassay and immunoprecipitation experiments
Ohike Y; Imai M; Tanaka E; Mukaida N; Kasahara T; Tachibana K; Miyakawa Y; Mayumi M
Two monoclonal antibodies were raised against human interleukin-2 ( IL-2 ) produced by E. coli harboring recombinant complemental DNA. Both antibodies did not neutralize its activity, nor did they inhibit the binding of IL-2 to the receptor on target cells. Taking advant
Slow infections raise some novel issues in understanding the pathogenesis of viral diseases that have been increasingly addressed at the molecular level with in situ hybridization. These developments are reviewed as the framework for discussion of the realized and potential impact of these investigations for major neu
Groopman JE; Chen FW; Hope JA; Andrews JM; Swift RL; Benton CV; Sullivan JL; Volberding PA; Sites DP; Landesman S; et al
Current efforts to test blood donors and other persons for exposure to the human T cell lymphotropic virus type III (HTLV-III), the etiologic agent of the acquired immunodeficiency syndrome (AIDS), are based on the measurement of serum antibodies to viral antigens. We studied presence of serum antibodies to HTLV-III-r
Fujii M; Sugamura K; Sano K; Nakai M; Sugita K; Hinuma Y
Receptor-mediated internalization and degradation of IL-2 were investigated in cell lines carrying human T cell leukemia/lymphoma (lymphotrophic) virus type I (HTLV-I) and PHA-treated normal PBL. The HTLV-I-carrying cell lines ILT-Yan and TL-Mor, and the PBL expressed
Approximately one-half of autopsied acquired immune deficiency syndrome (AIDS) patients demonstrate probable human cytomegalovirus ( CMV ) infection of the central nervous system (CNS). Because CMV in brain tissue or cerebrospi
Kikukawa R; Koyanagi Y; Harada S; Kobayashi N; Hatanaka M; Yamamoto N
Cells of human leukemic T-cell line Molt-4 which were cloned in soft agarose from individual colonies were analyzed for the cytopathic effect and viral antigen expression after human T-cell lymphotropic virus type III infection. The induction of cytopathic effect and viral antigens by the infection varied significantl
The ability of the sequences present in the long terminal repeats (LTRs) of human T-cell leukemia viruses type I and II (HTLV-I and HTLV-II) and of bovine leukemia virus to function as enhancer elements was investigated. Recombinant plasmids that contained the HTLV-I, HTLV-II, and bovine leukemia virus LTRs at a dista
Fultz PN; McClure HM; Swenson RB; McGrath CR; Brodie A; Getchell JP; Jensen FC; Anderson DC; Broderson JR; Francis DP
The lymphadenopathy-associated virus (LAV) prototype strain of human T-lymphotropic virus type III/LAV was transmitted to juvenile chimpanzees with no prior immunostimulation by (i) intravenous injection of autologous cells infected in vitro, (ii) intravenous injection of cell-free virus, and (iii) transfusion from a
Sera from the majority of individuals that were positive in an enzyme-linked immunosorbent assay (ELISA) retrovirus (ARV), an isolate of the for antibodies to acquired immune deficiency syndrome (AIDS)-associated retrovirus (ARV), an isolate of the retrovirus identified as the etiologic agent of AIDS, were found to re
Resnick L; Veren K; Salahuddin SZ; Tondreau S; Markham PD
The stability of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) under environmental conditions encountered in a clinical or laboratory setting and its inactivation by commonly used chemical disinfectants were investigated. Under our experimental conditions utilizing a highly c
The clinical, immunological, and serological status of 28 patients with hemophilia A and of 13 patients with hemophilia B was investigated. Thirty-four patients were treated regularly by clotting factor concentrates and 7 patients had been substituted only 1 to 4 times. Almost all patients with severe hemophilia suffe
N Engl J Med. 1986 Mar 27;314(13):801-5. Unique Identifier : AIDSLINE MED/86146785
The drug 9-(1,3-dihydroxy-2-propoxymethyl)-guanine (DHPG) was used to treat serious cytomegalovirus infections in 26 patients with underlying immunodeficiency (including 22 with the acquired immunodeficiency syndrome). In 17 of 22 patients in whom cytomegalovirus was virologically
Patients with the acquired immunodeficiency syndrome (AIDS) acquire undifferentiated B-cell lymphomas that are similar to African Burkitt s lymphoma and contain Epstein-Barr virus (EBV). Using an in vitro assay system that measures a complex of cellular responses to EBV-infected lymphocytes, we found that B cells from
Minerva Med. 1986 Mar 10;77(9-10):273-7. Unique Identifier : AIDSLINE MED/86147441
Badellino F; Moresco L; Battistini G; Gipponi M; Percivale P; Dodi F; Anselmo M
The authors review the epidemiologic and etiopathogenetic aspects of AIDS, in agreement with data published in december by the Center for Disease Control and by the WHO for the States, Europe and Italy . In their experience twenty-one patients, with clinical clues of AIDS, undergoing
Aymard JP; Janot C; Briquel ME; Andre E; Schooneman F; Vigneron C; Legras B; Alexandre P; Streiff F
Blood T-lymphocyte subsets and serum immunoglobulin levels were studied in a group of 52 haemophiliacs (44 patients with haemophilia A and 8 patients with haemophilia B). None of the patients had AIDS or belonged to any AIDS high-risk group. Patients were exclusively treated with clotting fractions obtained from healt
Proc Natl Acad Sci U S A. 1986 Feb;83(4):1089-91. Unique Identifier : AIDSLINE MED/86149220
Cowan MJ; Brady RO; Widder KJ
Acquired immunodeficiency syndrome (AIDS) is an often fatal disease caused by a retrovirus frequently resulting in malignancy and/or opportunistic infection. Because the immune deficiency in AIDS is similar to that in some purine enzyme deficiencies, we measured erythrocyte adenosine deaminase (ADA) and purine nucleos
Proc Natl Acad Sci U S A. 1986 Mar;83(6):1911-5. Unique Identifier : AIDSLINE MED/86149407
Mitsuya H; Broder S
Human T-lymphotropic virus type III (HTLV-III)/lymphadenopathy-associated virus (LAV) is a a newly discovered lymphotropic retrovirus that is cytopathic for helper/inducer T cells in vitro. This virus is the etiologic agent of the acquired immunodeficiency syndrome and related diseases. In the current study, we tested
The frequency of nine reactivating or opportunistic infections and Kaposi s sarcoma among patients with the acquired immunodeficiency syndrome (AIDS) was reviewed. The diagnoses of 87 patients reported from the Colorado AIDS registry and 359 others from literature reports were abstracted, and data were placed in one o
Science. 1986 Mar 21;231(4744):1437-40. Unique Identifier : AIDSLINE MED/86151654
Derse D; Casey JW
The bovine leukemia virus, like the human T-cell leukemia viruses (HTLV-I and HTLV-II), are unusual biologically in that viral transcripts are not detected in tumors or infected tissues. The bovine leukemia virus long terminal repeat (BLV LTR) functions as a transcriptional promoter only in cell lines productively inf
Science. 1986 Mar 28;231(4745):1546-9. Unique Identifier : AIDSLINE GENBANK/K03455
Lee TH; Coligan JE; Allan JS; McLane MF; Groopman JE; Essex M
The DNA of the HTLV-III/LAV group of retroviruses contains certain additional open reading frames that are not found in typical avian or mammalian retroviruses. The role of these sequences in encoding for gene products that may be related to pathogenesis remains to be resolved. An open reading frame whose 5 end overl
The genome of the human T-lymphotropic virus type III (HTLV-III/LAV) has the potential to encode at least three polypeptides in addition to those encoded by the gag, pol, and env genes. In this study, the product of the sor (short open reading frame) region, which overlaps the 3 end of the pol gene, was found to be a
The nucleotide sequence of the genome of HTLV-III, the infectious agent etiologically associated with the acquired immune deficiency syndrome, predicts a small open reading frame, termed sor, located between the pol and env genes. A DNA segment containing 82 percent of the sor region was inserted into a prokaryotic ex
Science. 1986 Mar 28;231(4745):1556-9. Unique Identifier : AIDSLINE MED/86151664
Kennedy RC; Henkel RD; Pauletti D; Allan JS; Lee TH; Essex M; Dreesman GR
In a study performed to determine which regions of the human T-cell lymphotrophic virus type III (HTLV-III) may represent vaccine candidates to prevent the acquired immune deficiency syndrome (AIDS), a synthetic peptide corresponding to amino acid sequence 735 to 752 of the precursor envelope glycoprotein of HTLV-III
Science. 1986 Mar 28;231(4745):1567-72. Unique Identifier : AIDSLINE GENBANK/M11841
Power MD; Marx PA; Bryant ML; Gardner MB; Barr PJ; Luciw PA
Simian acquired immune deficiency syndrome (SAIDS) in the macaque genus of monkeys at the California Primate Research Center is apparently caused by infection by a type D retrovirus. The complete nucleotide sequence (8173 base pairs) of a molecular clone of the prototype SAIDS virus isolate, SRV-1, reveals a typical r
The gag-pol gene of HTLV-III (human T-lymphotropic virus), the virus linked to AIDS (acquired immune deficiency syndrome), was expressed in yeast, and processing of the gag precursor into proteins of the same size as those in the virion was observed. Processing of the gag gene in yeast cells mimics the process that na
Kanki PJ; Barin F; M'Boup S; Allan JS; Romet-Lemonne JL; Marlink R; McLane MF; Lee TH; Arbeille B; Denis F; et al
This report describes serologic evidence for a virus similar to that known as simian T-lymphotropic virus type III of African Green monkeys (STLV-IIIAGM) infecting apparently healthy people in Senegal , West Africa, and the isolation of virus from these individuals. Serum samples f
Conceptualizing a population as a set of individuals linked together to form a large social network provides a fruitful perspective for better understanding the spread of some infectious diseases. Data related to AIDS (the acquired immune deficiency syndrome) were used to illustrate the potential usefulness of a netwo
South Med J. 1986 Mar;79(3):368-70. Unique Identifier : AIDSLINE MED/86151895
Schneiderman H; Robert NJ; Walker S; Memoli VA
We have reported a case of herpes genitalis in a man with acquired immunodeficiency syndrome (AIDS), who was receiving chemotherapy for Hodgkin s disease. The herpes infection was recurrent but limited, without vesicles or the progressive lesions usually seen in AIDS. Studies excluded known causes, and the unusual cha
From April 22 to July 28, and from October 7 to November 3, 1985 the American Red Cross, the Council of Community Blood Centers, the American Association of Blood Banks, and the American Blood Resources Association provided the Food and Drug Administration with data at 2-week intervals on human T-lymphotropic virus ty
A population of 73 donor samples was assembled on the basis of reactive results in routine screening with three different licensed human T-lymphotrophic virus type III (HTLV-III) antibody enzyme-linked immunosorbent assay (ELISA) procedures. The samples were retested by a number of licensed and developmental tests and
Wells MA; Wittek AE; Epstein JS; Marcus-Sekura C; Daniel S; Tankersley DL; Preston MS; Quinnan GV Jr
Because of concern about the safety of immune globulins prepared for injection, we studied the effects of ethanol fractionation of human plasma on human lymphotropic virus, type III, (HTLV-III) by spiking the products of various fractionation steps with HTLV-III. Tests of inactivation and removal indicated that the ra
Vet Immunol Immunopathol. 1986 Jan;11(1):1-19. Unique Identifier : AIDSLINE MED/86153573
Yamamoto JK; Ho E; Pedersen NC
A cell-line, designated LSA-1, was derived from a thymic lymphosarcoma that occurred in a cat with experimentally induced feline leukemia virus (FeLV) infection. LSA-1 cells possessed surface receptors and antigens of normal T-lymphocytes, but were unresponsive to interleukin-2 stimulation. The LSA cell-line was found
Rasheed S; Norman GL; Gill PS; Meyer PR; Cheng L; Levine AM
Human retroviruses have been causally associated with the development of the acquired immune deficiency syndrome (AIDS) in groups of individuals at high risk including intravenous drug users, hemophiliacs, and homosexual men. Aside from classic AIDS, homosexual men also develop persistent generalized lymphadenopathy (
Newman MJ; Baker IT; Reitz MS; Eiden M; Blattner WA; Gallo RC; Mann DL
Murine monoclonal antibodies were developed against the protein products produced by murine C127 cells which had been transfected with a recombinant plasmid clone containing the human T-cell leukemia (lymphotropic) virus type I (HTLV-I) proviral DNA coding regions for part of env, px, and the 3 LTR. Four antibodies w
Horizontally acquired SAIDS retrovirus type 2 (SRV-2), a type D retrovirus related to the Mason- Pfizer monkey virus, has been associated with the simian acquired immunodeficiency syndrome (SAIDS) including retroperitoneal fibromatosis (RF) in several macaque species at two
Steimer KS; Puma JP; Power MD; Powers MA; George-Nascimento C; Stephans JC; Levy JA; Sanchez-Pescador R; Luciw PA; Barr PJ; et al
Infection with the retrovirus that is the etiological agent of acquired immune deficiency syndrome (AIDS) is characterized by the development of antiviral antibodies. To generate reagents for studying immune responses to individual viral proteins, we have produced viral antigens in microorganisms by recombinant DNA te
Goudsmit J; Miedema F; Breederveld C; Terpstra F; Roos M; Schellekens P; Melief C
95 Dutch haemophiliacs were tested for antibodies to membrane antigens on cells infected with human T-cell leukemia virus type I (HTLV-I-MA) by indirect immunofluorescence and to purified HTLV-I by enzyme-linked immunosorbent assay. Antibodies to HTLV-I-MA were present in 8 of 95 (8%) haemophiliacs, but only 3 (3%) ha
Babaiants AA; Manakhova LS; Karganova GG; Porkhovatyi SIa; Kondratenko IV
The capacity of leukocytes from children with primary immunodeficiency to produce alpha- and gamma-interferons in vitro was studied. Interferon response of leukocytes in most of the patients examined was found to be practically unchanged. The immunostimulating therapy in some cases exerted a regulating effect on leuko
Of more than 500 diseases or syndromes studied for HL-A markers, more than 40 are known to be associated with an allele of class I, II, or III. Seven are linked to the HL-A region: six are recessive (idiopathic hemochromatosis, C2, C4A, and C4B deficiencies, congenital and late-onset deficiencies) and one is dominant
Am J Med. 1986 Mar;80(3):345-50. Unique Identifier : AIDSLINE MED/86155811
Kreiss JK; Kitchen LW; Prince HE; Kasper CK; Goldstein AL; Naylor PH; Preble O; Stewart JA; Essex M
A cohort of 63 hemophiliac subjects was followed for clinical and immunologic abnormalities related to the acquired immune deficiency syndrome (AIDS). When evaluated in early 1984, antibody to human T cell leukemia virus type III (HTLV-III) was detected in the serum of 59 percent (24 of 41) of factor VIII or IX concen
Am J Med. 1986 Mar;80(3):357-63. Unique Identifier : AIDSLINE MED/86155813
Mayer KH; Ayotte D; Groopman JE; Stoddard AM; Sarngadharan M; Gallo R
Forty asymptomatic homosexually active men seen at a Boston community health center and 39 men with generalized lymphadenopathy were interviewed and filled out detailed epidemiologic questionnaires. Twenty percent of the asymptomatic men and 92 percent of those with lymphadenopathy had antibodies to human T lymphotrop
A computer program was developed for use on an Apple IIe that utilized the parameters developed by Hopp and Woods (T. P. Hopp and K. R. Woods, 1983, Mol. Immunol. 20, 483-489) for predicting the hydrophilic regions of a given protein. This program will produce a listing of the hydrophilic sequence averages and graphic
Health care workers may be exposed to a variety of infectious agents in the workplace. The pregnant health care worker presents additional concerns because of the potential risk of infection to the developing fetus. Health care workers often misunderstand the basic elements of infection transmission. The result of thi
Bronchoalveolar lavage material from 54 immunocompromised patients with interstitial pneumonia was examined by immunofluorescence with cytomegalovirus-specific monoclonal antibodies. Twelve patients (22%) had cytomegalovirus detected in their lavaged cells, and 9 of these patients (17%) had proven cytomegalovirus pneu
Ann Intern Med. 1986 Apr;104(4):496-500. Unique Identifier : AIDSLINE MED/86157213
Melbye M; Biggar RJ; Ebbesen P; Neuland C; Goedert JJ; Faber V; Lorenzen I; Skinhoj P; Gallo RC; Blattner WA
The long-term effects of seropositivity for human T-lymphotropic virus type III (HTLV-III) on T-lymphocyte subsets and health status were evaluated in longitudinal studies of 250 initially healthy homosexual men. The relative risk of having an inverted T-lymphocyte helper-to-suppressor ratio rose from 14.3-fold among
This study was undertaken to compare prospectively the diagnostic yield of the various bronchoscopic techniques with that of open-lung biopsy for interstitial lung disease in patients with acquired immunodeficiency syndrome (AIDS). Under general anesthesia, 15 patients sequentially underwent bronchial washing, transbr
During studies of the pathogenesis of murine cytomegalovirus (MCMV) infection in athymic nude mice, we noted striking virus involvement of the adrenal glands. Because patients with the acquired immunodeficiency syndrome (AIDS) have recently been reported to have adrenal necrosis an
Boumpas DT; Popovic M; Mann DL; Balow JE; Tsokos GC
Type C retroviruses of the human T cell leukemia virus (HTLV) family have been implicated in immune aberrations observed in patients with leukemias, lymphomas, and the acquired immune deficiency syndrome. We have investigated whether retroviruses of the HTLV family are involved in the etiopathogenesis of systemic lupu
Cervical secretions from 14 women seropositive for HTLV-III/LAV were obtained between days 7 and 21 of the menstrual cycle and cultured for virus. HTLV-III/LAV was isolated from cervical secretions in 4 of 14 women, as well as from blood of 7 of 13 women tested. Female genital secretions may therefore be a source for
Lancet. 1986 Mar 8;1(8480):527-9. Unique Identifier : AIDSLINE MED/86145843
Wofsy CB; Cohen JB; Hauer LB; Padian NS; Michaelis BA; Evans LA; Levy JA
The AIDS-associated retrovirus (ARV) was isolated from vaginal and/or cervical secretions from 4 out of 8 women whose sera contained antibodies to the virus. The quantity of virus recovered initially was so low that identification of ARV was accomplished only after passage of the isolates to cultured mitogen-stimulate
Lancet. 1986 Mar 15;1(8481):575-80. Unique Identifier : AIDSLINE MED/86145883
Yarchoan R; Klecker RW; Weinhold KJ; Markham PD; Lyerly HK; Durack DT; Gelmann E; Lehrman SN; Blum RM; Barry DW; et al
In a 6-week clinical trial 4 dose regimens of 3 -azido-3 -deoxythymidine ( AZT ), a thymidine analogue with potent anti-viral activity against HTLV-III in vitro, were examined in 19 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-rel
Lancet. 1986 Mar 15;1(8481):581-3. Unique Identifier : AIDSLINE MED/86145884
Webster AD; Dalgleish AG; Malkovsky M; Beattie R; Patterson S; Asherson GL; North M; Weiss RA
Retroviruses related to human T-lymphotropic virus III/lymphadenopathy-associated virus (HTLV-III/LAV) have been isolated from peripheral-blood mononuclear cells of two patients with common variable hypogammaglobulinaemia who were being treated with intravenous gammaglobulin. One has had three different opportunistic
The level of antibody to AIDS-associated virus (LAV) in sera from patients with AIDS or AIDS related diseases (AIDS related complex; ARC) and Japanese hemophiliacs was studied using indirect immunofluorescence. Titer of anti-LAV antibody in sera from 89 patients with AIDS or ARC ranged between 10 and 40,960 (median: 1
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