HUMAN T LYMPHOTROPIC VIRUSES (HTLV) INHIBIT T LYMPHOCYTE MITOGENESIS. SELECTIVE RESTORATION OF RESPONSIVENESS BY ADDITION OF T CELL GROWTH FACTOR NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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HUMAN T LYMPHOTROPIC VIRUSES (HTLV) INHIBIT T LYMPHOCYTE MITOGENESIS. SELECTIVE RESTORATION OF RESPONSIVENESS BY ADDITION OF T CELL GROWTH FACTOR

Prog Leukocyte Biol; 1:77-88 1985. Unique Identifier : AIDSLINE ICDB/86620619
Wainberg MA; Roy S; Spira B; Blain N; Lady Davis Inst. for Medical Res., Sir Mortimer B. Davis-Jewish; General Hosp., Montreal Quebec H3T 1E2, Canada

Abstract: Anti-lymphocyte proliferative properties, similar to those possessed by many retroviruses, were studied in the human T lymphotropic (HTLV). To characterize the effect of exposure to HTLV on lymphocyte proliferation, HTLV-I, HTLV-III, and avian sarcoma virus (ASV) were inactivated by ultraviolet irradiation and then co-cultured with human peripheral blood lymphocytes (PBL). The presence of inactivated HTLV-I or HTLV-III markedly inhibited the proliferative response of PBL to mitogen stimulation and the generation of T cell growth factor (TCGF) activity. Inhibition of both lymphocyte mitogenesis and TCGF biogenesis was in a virus concentration-dependent manner. The addition of exogenous TCGF restored the proliferative response after inhibition by HTLV-III or ASV but not by HTLV-I. The authors conclude that ASV, HTLV-III, and HTLV-I impair the response of human lymphoid cells to mitogenic stimulus; that this effect can largely be overcome by inclusion in the culture medium of purified TCGF; and that HTLV-I, uniquely among the retroviruses tested to date, induces a TCGF-unresponsive state. (25 Refs)
Keywords: Human HTLV-BLV Viruses/*IMMUNOLOGY/RADIATION EFFECTS Immune Tolerance Interleukin-2/*IMMUNOLOGY *Lymphocyte Transformation Phytohemagglutinins/IMMUNOLOGY Sarcoma Viruses, Avian/IMMUNOLOGY/RADIATION EFFECTS T-Lymphocytes/IMMUNOLOGY Ultraviolet Rays MEETING PAPER

KWDhumanhtlv-blvviruses/KWDimmunology/radiationeffectsimmunetoleranceinterleukin-2/KWDimmunologyKWDlymphocytetransformationphytohemagglutinins/immunologysarcomaviruses,avian/immunology/radiationeffectst-lymphocytes/immunologyultravioletraysmeetingpaper
860730
M8670315

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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