EPSTEIN-BARR VIRUS, IMMUNE DEFECTS AND LYMPHOPROLIFERATIVE DISORDERS NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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EPSTEIN-BARR VIRUS, IMMUNE DEFECTS AND LYMPHOPROLIFERATIVE DISORDERS

Prog Leukocyte Biol; 1:135-58 1985. Unique Identifier : AIDSLINE ICDB/86620621
Purtilo DT; Dept. of Pathology and Lab. Medicine, Univ. of Nebraska Medical; Sch. Omaha, NE 68105

Abstract: Immune deterrence of EBV-induced lymphoproliferative diseases is reviewed. EBV is tropic for B lymphocytes, oropharyngeal cells and possibly parotid duct cells. The occurrence of Burkitt's lymphoma (BL) in African children and of nasopharyngeal carcinoma (NPC) in Chinese adults appears to represent secondary EBV effects in immunocompromised hosts. The immunologic response to EBV infection includes increased T-suppressor activity, anomalous T-cell cytotoxicity and specific antibodies. Patients (pts) with the X-linked lymphoproliferative syndrome (XLP) develop severe EBV diseases, probably as a result of preexisting immune regulatory defects. Similar defects appear to occur in pts with Wiskott-Aldrich syndrome and ataxia telangiectasia. EBV malignancies occur in pts with inherited immune deficiencies, pharmacologic immunosuppression for renal transplantation, and the acquired immunodeficiency syndrome (AIDS), as well as in persons in endemic regions of Africa. Characteristic cytogenetic changes occur in BL, including the appearance of 14q+, trisomy 14, 6q+ and trisomy 11. It has been suggested that the approximation of an active immunoglobin locus with the locus of c-myc on chromosome 8 results in the production of gene products of c-myc. Possible therapeutic interventions in EBV lymphoproliferative diseases include active vaccination, gammaglobulin prophylaxis, interferon, acycloguanosine, withdrawal of pharmacologic immunosuppression in allografted pts who develop EBV-carrying lesions, conventional treatment for malignancies if they occur, and bone marrow transplantation. (61 Refs)
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/MICROBIOLOGY Antibodies, Viral/ANALYSIS Antibody Specificity Antigens, Viral/IMMUNOLOGY Burkitt's Lymphoma/GENETICS/IMMUNOLOGY/MICROBIOLOGY Herpesvirus 4, Human/GENETICS/*IMMUNOLOGY Human Immune Tolerance Immunologic Deficiency Syndromes/GENETICS/*IMMUNOLOGY/ MICROBIOLOGY Infectious Mononucleosis/IMMUNOLOGY Karyotyping Lymphoproliferative Disorders/GENETICS/*IMMUNOLOGY Neoplasms/ETIOLOGY/MICROBIOLOGY Tumor Virus Infections/GENETICS/*IMMUNOLOGY MEETING PAPER

KWDacquiredimmunodeficiencysyndrome/immunology/microbiologyantibodies,viral/analysisantibodyspecificityantigens,viral/immunologyburkitt'slymphoma/genetics/immunology/microbiologyherpesvirus4,human/genetics/KWDimmunologyhumanimmunetoleranceimmunologicdeficiencysyndromes/genetics/KWDimmunology/microbiologyinfectiousmononucleosis/immunologykaryotypinglymphoproliferativedisorders/genetics/KWDimmunologyneoplasms/etiology/microbiologytumorvirusinfections/genetics/KWDimmunologymeetingpaper
860730
M8670314

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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