VIRAL MECHANISMS OF IMMUNOSUPPRESSION: CELLS OF THE IMMUNE SYSTEM AS TARGETS OF VIRAL INFECTION AND FEEDBACK INHIBITION BY SUPPRESSOR CELLS AND IMMUNOGLOBULINS NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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VIRAL MECHANISMS OF IMMUNOSUPPRESSION: CELLS OF THE IMMUNE SYSTEM AS TARGETS OF VIRAL INFECTION AND FEEDBACK INHIBITION BY SUPPRESSOR CELLS AND IMMUNOGLOBULINS

Prog Leukocyte Biol; 1:265-71 1985. Unique Identifier : AIDSLINE ICDB/86620628
Joncas JH; Dept. of Microbiology and Immunology, Sainte-Justine Hosp.,; Montreal, Quebec H3T 1C5

Abstract: Viral mechanisms of immunosuppression are discussed. Certain viruses, including Epstein-Barr virus (EBV), cytomegalovirus and human T lymphotropic virus-III can directly infect cells of the immune system. Although cell lysis can occur, most lymphoid cells are or become poorly permissive for viral replication. Target cells include B cells, T cells and macrophages. Immunosuppression can also occur as a result of end products of immune response, ie, immunoglobulin and antibodies, which act as soluble blocking factors. Immune suppression due to antibody or immune complexes may reflect a physiologic, regulatory feedback mechanism, probably involving specific receptors on effector cells. The persistence of immunosuppression in patients with certain chronic active viral infections may be the result of an underlying target cell defect, or it may be due to the formation of immune complexes between virus-induced antigens and antibody. In the case of EBV, complexes of EBV nuclear antigen and antibody could inhibit the immune response. (30 Refs)
Keywords: Antigen-Antibody Complex/IMMUNOLOGY Antigens, Viral/IMMUNOLOGY Cytomegalovirus/IMMUNOLOGY Feedback Herpesvirus 4, Human/IMMUNOLOGY Human HTLV-BLV Viruses/IMMUNOLOGY Immune Tolerance Immunoglobulins/*IMMUNOLOGY Immunologic Deficiency Syndromes/*IMMUNOLOGY Immunologic Memory Lymphoproliferative Disorders/IMMUNOLOGY T-Lymphocytes/IMMUNOLOGY T-Lymphocytes, Suppressor-Effector/*IMMUNOLOGY Virus Diseases/*IMMUNOLOGY MEETING PAPER

KWDantigen-antibodycomplex/immunologyantigens,viral/immunologycytomegalovirus/immunologyfeedbackherpesvirus4,human/immunologyhumanhtlv-blvviruses/immunologyimmunetoleranceimmunoglobulins/KWDimmunologyimmunologicdeficiencysyndromes/KWDimmunologyimmunologicmemorylymphoproliferativedisorders/immunologyt-lymphocytes/immunologyt-lymphocytes,suppressor-effector/KWDimmunologyvirusdiseases/KWDimmunologymeetingpaper
860730
M8670310

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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