Serum immunoglobulin G subclass dysbalances in the lymphadenopathy syndrome and acquired immune deficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Serum immunoglobulin G subclass dysbalances in the lymphadenopathy syndrome and acquired immune deficiency syndrome.

Clin Exp Immunol. 1986 Jan;63(1):234-40. Unique Identifier : AIDSLINE MED/86162299
Aucouturier P; Couderc LJ; Gouet D; Danon F; Gombert J; Matheron S; Saimot AG; Clauvel JP; Preud'homme JL

Abstract: Serum IgG subclass levels were measured by an indirect competitive immunoenzymatic assay with monoclonal antibodies in 61 adult patients of different geographic origins affected either with the lymphoadenopathy syndrome (LAS, 46 cases) or with the acquired immune deficiency syndrome (AIDS, 15 cases). In spite of considerable variations from patient to patient, IgG-1 and IgG-3 levels were higher than in normal Caucasians, with IgG-1 levels much more elevated in LAS than in AIDS patients. In Caucasians with AIDS or LAS, IgG-4 levels were low. IgG-2 levels tended to be low and correlated negatively with IgG-1 levels. IgG subclass imbalances were especially striking in patients with lymphoid interstitial pneumonitis. The results suggest that the IgG increase predominantly affects the less T-dependent subclasses. The low levels of the more T-dependent isotypes do not appear to play a clear role in the occurrence of pyogenic infections in certain patients.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Adult Ethnic Groups Female France Human IgA/ANALYSIS IgG/*ANALYSIS/CLASSIFICATION IgM/ANALYSIS Lymphatic Diseases/*IMMUNOLOGY Male Middle Age JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyadultethnicgroupsfemalefrancehumaniga/analysisigg/KWDanalysis/classificationigm/analysislymphaticdiseases/KWDimmunologymalemiddleagejournalarticle
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M8670279

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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