Pathogenesis of simian AIDS in rhesus macaques inoculated with the SRV-1 strain of type D retrovirus. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Pathogenesis of simian AIDS in rhesus macaques inoculated with the SRV-1 strain of type D retrovirus.

Am J Vet Res. 1986 Apr;47(4):863-8. Unique Identifier : AIDSLINE MED/86184908
Maul DH; Lerche NW; Osborn KG; Marx PA; Zaiss C; Spinner A; Kluge JD; MacKenzie MR; Lowenstine LJ; Bryant ML; et al

Abstract: Type D retrovirus was isolated from rhesus macaques with simian acquired immunodeficiency syndrome (SAIDS) and transmitted to healthy rhesus macaques with tissue culture medium containing the virus. The clinical, immunologic, and lymph node morphologic changes were observed in 9 rhesus macaques for 52 weeks after inoculation. A spectrum of clinical signs developed including early death, persistent SAIDS, and apparent remission. Animals that died or developed persistent SAIDS had characteristic lymphoid depletion, persistently depressed peripheral blood mononuclear cell (PBMC) mitogenic response, and decreased serum immunoglobulins. The SAIDS retrovirus (SRV) was recovered from PBMC of 8 of the animals after inoculation. Virus could not be recovered from PBMC of one animal in remission, but this animal developed serum-neutralizing antibodies to SRV after inoculation. Seven of the animals seroconverted to SRV after inoculation, all 9 were seronegative for human T-lymphotropic virus-III, and 5 animals tested were seronegative to human T-lymphotropic virus-I. These findings support the etiologic role of the type D retrovirus in SAIDS and further define the pathogenesis of this disease.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*MICROBIOLOGY Animal Female Immunoglobulins/ANALYSIS Macaca/*MICROBIOLOGY Macaca mulatta/*MICROBIOLOGY Male Mitogens Retroviridae/ISOLATION & PURIF/*PATHOGENICITY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/immunology/KWDmicrobiologyanimalfemaleimmunoglobulins/analysismacaca/KWDmicrobiologymacacamulatta/KWDmicrobiologymalemitogensretroviridae/isolation&purif/KWDpathogenicitysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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