EVALUATION OF BLOOD LEVELS OF THYMIC HORMONES IN HEALTH AND DISEASE NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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EVALUATION OF BLOOD LEVELS OF THYMIC HORMONES IN HEALTH AND DISEASE

Serono Symp Publ; 16:43-51 1984. Unique Identifier : AIDSLINE ICDB/85614607
Dardenne M; Inserm U 25, Hopital Necker, Paris, France

Abstract: Methods for assay of thymic hormones in human blood are reviewed, and serum levels of the thymic hormones are given for healthy subjects and for patients with various diseases. These levels have been evaluated mainly in primary or secondary immune deficiencies or in autoimmune diseases, using either a rosette assay, the Twomey assay, or radioimmunoassay (RIA). Diseases in which serum thymic hormones have been studied include DiGeorge's syndrome, severe combined immunodeficiency, common variable immunodeficiency, IgA deficiency, acquired immunodeficiency syndrome (AIDS), systemic lupus erythematosus, myasthenia gravis, chronic graft versus host disease, thymomas, and mycosis fungoides. It was concluded that techniques for assay of serum levels of thymic hormones are now available for clinical use; biological methods are used mainly, but RIA techniques may soon be in widespread use. Even with the availability of RIA, biological assays will still be necessary to distinguish various components that participate in circulating thymic hormone activity, including carriers and inhibitors. (36 Refs)
Keywords: Acquired Immunodeficiency Syndrome/BLOOD Animal Autoimmune Diseases/BLOOD Biological Assay Dysgammaglobulinemia/BLOOD Graft vs Host Disease/BLOOD Human IgA/DEFICIENCY Immunologic Deficiency Syndromes/*BLOOD Mice Mycosis Fungoides/BLOOD Radioimmunoassay Thymoma/BLOOD Thymus Hormones/*BLOOD Thymus Neoplasms/BLOOD JOURNAL ARTICLE REVIEW

KWDacquiredimmunodeficiencysyndrome/bloodanimalautoimmunediseases/bloodbiologicalassaydysgammaglobulinemia/bloodgraftvshostdisease/bloodhumaniga/deficiencyimmunologicdeficiencysyndromes/KWDbloodmicemycosisfungoides/bloodradioimmunoassaythymoma/bloodthymushormones/KWDbloodthymusneoplasms/bloodjournalarticlereview
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Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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