Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.
CLASSICAL AND AIDS KAPOSI'S SARCOMA
Histocompatibility Testing 1984. Albert ED, Baur MP, Mayr WR, eds. New York, Springer-Verlag, p. 403-6, 1984.. Unique Identifier : AIDSLINE ICDB/85614630 Pollack MS; Falk J; Gazit E; Lawrence D; Safai B; Rubenstein P; Dupont B; Baylor Coll. of Medicine, Houston, TX 77030
Abstract:
Acquired immunodeficiency syndrome (AIDS) patients (pts) always have evidence of defective cellular immunity, including lymphopenia and grossly decreased ratios of helper to suppressor T cells. Cutaneous anergy and diminished proliferative responses to mitogens and specific antigens are also often observed. The AIDS syndrome is manifested by the occurrence of unusual, severe opportunistic infections (OIs) and/or malignancies not seen in individuals with normal immune systems; more than a third of the homosexual AIDS pts develop Kaposi's sarcoma (KS). An HLA-DR5 association has been established among unrelated pts with AIDS-KS in New York, and a similar association was also reported for a smaller group of AIDS-KS patients in Los Angeles. A study was performed to clarify and confirm the previously reported HLA associations and to determine whether the same or different HLA associations would be found in other pt populations. Although the 'family study' requirement for disease studies discouraged the submission of family data from AIDS-KS or AIDS-OI pts, sufficient family HLA data for classical KS pts and sufficient new AIDS-KS data are available to confirm that a significant HLA association may indeed exist for both forms of this malignancy. Data analysis found no new significant deviations in HLA-A, B antigen frequencies. The results of the new data summarized in this report are consistent with previous reports: decreases in B8 and DR3 among AIDS-KS pts, an increase in B44 in AIDS-KS, and a DR5 increase in Italian pts with either classical or AIDS-KS. In addition to the HLA data described, additional observations are reported: pts with classical form of KS do not show grossly abnormal T4:T8 lymphocyte subclass ratios and there are no HLA antigen associations with AIDS patients' levels of antibodies to human T4 lymphotropic retrovirus antigens. These observations, together with HLA antigen frequency data, support the hypothesis that the etiology of classical and AIDS-KS involves different initiation steps, but that HLA-associated immune response factors may determine which already susceptible individuals develop manifest malignant disease. (10 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Caucasoid Race Genetic Markers Histocompatibility Antigens Class II/ANALYSIS Human HLA Antigens/*ANALYSIS Male Negroid Race Sarcoma, Kaposi's/GENETICS/*IMMUNOLOGY MEETING PAPER
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Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.
