An immunopathologic evaluation of lymph nodes from monkey and man with acquired immune deficiency syndrome and related conditions.

Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

An immunopathologic evaluation of lymph nodes from monkey and man with acquired immune deficiency syndrome and related conditions.

Hematol Oncol. 1985 Jul-Sep;3(3):199-210. Unique Identifier : AIDSLINE MED/86006684
Meyer PR; Ormerod LD; Osborn KG; Lowenstine LJ; Hendrickson RV; Modlin RL; Smith RE; Gardner MB; Taylor CR

Abstract: Morphology and immunostaining of lymph nodes taken from rhesus monkeys and man are compared. The monkeys were inoculated with biologic materials known to transmit simian acquired immune deficiency syndrome (SAIDS) and the human biopsies were obtained from homosexual men with persistent generalized lymphadenopathy syndrome or acquired immune deficiency syndrome (AIDS). The lymph nodes from monkey and man share common immunohistochemical features, ranging from exhuberant follicular hyperplasia to lymphocyte depletion stage. The follicular hyperplasia differed from reactive controls by the larger follicular size and disorganization within the follicular centers as well as an increase in the number of cells with the T suppressor/cytotoxic phenotype. The lymphocyte depletion stage showed a loss of reactive follicles and small T lymphocytes with a predominance of mature monocytes/macrophages. Most monkeys and humans with the lymphocyte depletion morphology fulfilled the case definitions for AIDS and SAIDS while those with follicular hyperplasia usually had 'prodromal' findings. The simian agent is associated with alterations in lymph node morphology and immunostaining which parallel the changes seen in spontaneous human cases supporting a similar pathogenesis for AIDS and SAIDS.

Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*PATHOLOGY/ VETERINARY Animal Antibodies, Monoclonal/DIAGNOSTIC USE Antigens, Surface/ANALYSIS Comparative Study Homosexuality Human Hyperplasia Lymph Nodes/IMMUNOLOGY/*PATHOLOGY Lymphatic Diseases/IMMUNOLOGY/*PATHOLOGY Lymphocytes/IMMUNOLOGY Macaca mulatta/IMMUNOLOGY/MICROBIOLOGY Monkey Diseases/IMMUNOLOGY/*PATHOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

860130
M8610168

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