Immunopotentiation of impaired lymphocyte functions in vitro by isoprinosine in prodromal subjects and AIDS patients. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Immunopotentiation of impaired lymphocyte functions in vitro by isoprinosine in prodromal subjects and AIDS patients.

Int J Immunopharmacol. 1985;7(4):511-4. Unique Identifier : AIDSLINE MED/86007190
Tsang P; Lew F; O'Brien G; Selikoff IJ; Bekesi JG

Abstract: Immunomodulative actions of isoprinosine were tested in 100 prodromal homosexual males and 23 patients who have been diagnosed with AIDS. All subjects showed reduced T helper cells although T suppressor cell counts were normal. Proliferative responses, particularly T cell-dependent B cell function, were severely impaired in prodromal and AIDS subjects. Upon co-cultivation of their lymphocytes with isoprinosine, significant upward modulation, and in some cases, normalization, of lymphocyte functions as monitored by PHA- and PWM-induced blastogenesis was achieved in prodromal subjects. Similar degrees of modulation but not normalization of lymphocyte functions were observed in patients with severe symptoms of AIDS.
Keywords: Acquired Immunodeficiency Syndrome/DRUG THERAPY/*IMMUNOLOGY *Adjuvants, Immunologic Adult Aged Dose-Response Relationship, Immunologic Homosexuality Human Inosine/*ANALOGS & DERIVATIVES Isoprinosine/*PHARMACOLOGY Leukocyte Count Lymphocyte Transformation/DRUG EFFECTS Male Middle Age Phenotype T-Lymphocytes/CLASSIFICATION/*DRUG EFFECTS/IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/drugtherapy/KWDimmunologyKWDadjuvants,immunologicadultageddose-responserelationship,immunologichomosexualityhumaninosine/KWDanalogs&derivativesisoprinosine/KWDpharmacologyleukocytecountlymphocytetransformation/drugeffectsmalemiddleagephenotypet-lymphocytes/classification/KWDdrugeffects/immunologyjournalarticle
860130
M8610121

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1986. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1986. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .