The natural history of Kaposi's sarcoma in the acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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The natural history of Kaposi's sarcoma in the acquired immunodeficiency syndrome.

Ann Intern Med. 1985 Nov;103(5):744-50. Unique Identifier : AIDSLINE MED/86023892
Safai B; Johnson KG; Myskowski PL; Koziner B; Yang SY; Cunningham-Rundles S; Godbold JH; Dupont B

Abstract: Kaposi's sarcoma is a multifocal systemic neoplasm histologically characterized by proliferating fibroblastic and microvascular elements. Initial signs include macules, papules, or nodules on the skin or mucosal surface. Lesions are frequently found on the trunk, arms, and head and neck. In general, sites of involvement and tumor load do not correlate with prognosis. A general decrease in the functional capacities of T and B cells is found in most patients. Kaposi's sarcoma is reported as the initial manifestation of the acquired immunodeficiency syndrome (AIDS) in approximately 30% of cases. Most cases are in men, although it has been reported in all risk groups. Kaposi's sarcoma in AIDS is more frequent among whites and homosexuals than blacks and intravenous drug abusers. Overall mortality is approximately 41%, with over 60% of patients alive at 1 year and 50% at 22 months. Overall survival is 18 months; however, some patients who have had the disease for 3 to 4 years are still doing well.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Aged Female Histocompatibility Antigens Class II/ANALYSIS Homosexuality Human Leukocyte Count Male Middle Age Racial Stocks Sarcoma, Kaposi's/BLOOD/EPIDEMIOLOGY/*ETIOLOGY/GENETICS/ IMMUNOLOGY/PATHOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/CLASSIFICATION JOURNAL ARTICLE REVIEW

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsadultagedfemalehistocompatibilityantigensclassii/analysishomosexualityhumanleukocytecountmalemiddleageracialstockssarcoma,kaposi's/blood/epidemiology/KWDetiology/genetics/immunology/pathologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/classificationjournalarticlereview
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Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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