Monocytoid B lymphocytes: their relation to the patterns of the acquired immunodeficiency syndrome (AIDS) and AIDS-related lymphadenopathy. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Monocytoid B lymphocytes: their relation to the patterns of the acquired immunodeficiency syndrome (AIDS) and AIDS-related lymphadenopathy.

Hum Pathol. 1985 Oct;16(10):979-85. Unique Identifier : AIDSLINE MED/86006761
Sohn CC; Sheibani K; Winberg CD; Rappaport H

Abstract: It was shown recently that monocytoid cells express B-cell-restricted antigens and polyclonal surface immunoglobulins, and the term monocytoid B lymphocytes (MBL) has thus been offered as a more appropriate designation. Although most commonly seen in toxoplasmic lymphadenitis, MBL have been observed in a variety of reactive and neoplastic conditions involving lymph nodes. In the present study MBL were found in 17 of 22 lymph nodes from 20 patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related lymphadenopathy. In all 17 samples, the MBL were found in lymph nodes with florid reactive follicular hyperplasia, and they were geographically close to the hyperplastic lymphoid follicles. However, MBL were not detected in lymph nodes showing involuted follicles or lymphocyte depletion. The disappearance of MBL apparently parallels the progressive involution of secondary follicles. Leu-3+/Leu-2+ (T-helper/T-suppressor) ratios were studied in 14 lymph node cell suspension samples and ten peripheral blood samples. The lymph node Leu-3+/Leu-2+ ratios were significantly lower in AIDS-related lymphadenopathy than in non-AIDS-related reactive follicular hyperplasia (P less than 0.001); the peripheral blood ratios were decreased in nine of the ten cases. The diminished T-helper status in patients with AIDS and AIDS-related lymphadenopathy may be relevant to the immunopathogenesis of follicular involution and, indirectly, to the disappearance of MBL.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*PATHOLOGY Adolescence Adult Antigens, Surface/ANALYSIS B-Lymphocytes/ANALYSIS/*PATHOLOGY Human Immunoglobulins, Surface/ANALYSIS Leukocyte Count Lymph Nodes/*PATHOLOGY Lymphatic Diseases/IMMUNOLOGY/*PATHOLOGY Male Middle Age Muramidase/ANALYSIS Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/CLASSIFICATION JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/immunology/KWDpathologyadolescenceadultantigens,surface/analysisb-lymphocytes/analysis/KWDpathologyhumanimmunoglobulins,surface/analysisleukocytecountlymphnodes/KWDpathologylymphaticdiseases/immunology/KWDpathologymalemiddleagemuramidase/analysissupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/classificationjournalarticle
860130
M8610105

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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