[Viral type particles in the germinal centers during a lymphadenopathic syndrome related to AIDS]

Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

[Viral type particles in the germinal centers during a lymphadenopathic syndrome related to AIDS]

Ann Pathol. 1985;5(2):137-42. Unique Identifier : AIDSLINE MED/86000006
Le Tourneau A; Audouin J; Aubert JP; Denis J; Baufine-Ducrocq H; Duterque M; Diebold J

Abstract: The identification of virus-like particles in the germinal centers of an AIDS-related lymph node with histological findings of group IA is reported. A 23 year-old man, intravenous drug user, presents an inversion of T helper/T suppressor cell ratio and a peripheral generalized lymphadenopathy, suggesting a diagnosis of ARC. Lymph node biopsy shows follicular hyperplasia and features consistent with group IA of AIDS-related lymphadenopathy. Immunohistochemical study reveals an increase of intrafollicular T8+ lymphocytes. Electronmicroscopic examination of follicles demonstrates the presence of particles showing features of viral nucleocapsids; these particles are seen between the cytoplasmic processes of follicular dendritic cells. Pathologic findings associated with lymphoid follicular hyperplasia in AIDS prodromal period are examined. The importance of lymph node biopsy with histological, immunohistochemical and ultrastructural studies, in patients at high risk for AIDS, is demonstrated. The detection of type D viral particles suggestive of retrovirus is in accordance with results of virologic studies which indicate the involvement of a retrovirus (called LAV or HTLV III) in the etiology of the disease.

Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/ETIOLOGY/ IMMUNOLOGY Adult Capsid/*ANALYSIS Case Report English Abstract Histocytochemistry Human Hyperplasia Lymph Nodes/*MICROBIOLOGY/PATHOLOGY Lymphatic Diseases/ETIOLOGY/*MICROBIOLOGY/PATHOLOGY Male Microscopy, Electron Substance Abuse/COMPLICATIONS T-Lymphocytes, Helper-Inducer/PATHOLOGY T-Lymphocytes, Suppressor-Effector/PATHOLOGY Viral Core Proteins/*ANALYSIS JOURNAL ARTICLE

860130
M8610101

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