Immunosuppression by human seminal plasma. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Immunosuppression by human seminal plasma.

Immunol Invest. 1985 Jun;14(3):255-69. Unique Identifier : AIDSLINE MED/86006960
Saxena S; Jha P; Farooq A

Abstract: Immunosuppressive property of normal human seminal plasma has been demonstrated on various in vitro immune parameters such as, blast transformation of lymphocytes with Phytohemagglutinin (P), Concanavalin A and Lipopolysaccharide, E & EAC rosette formation and mixed lymphocyte culture. The immunosuppression appears to be a T-cell mediated phenomenon. Analysis of semen samples obtained from 86 donors, comprising azoospermic, oligospermic, normospermic and polyspermic individuals, suggests that immunosuppression of the seminal plasma has no correlation with either the sperm density or the protein content of seminal plasma. The possible implication of the immunosuppressive activity in the development of acquired immuno-deficiency syndrome is also discussed.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY *Cytotoxicity, Immunologic Human *Immune Tolerance Lymphocyte Culture Test, Mixed *Lymphocyte Transformation Male Rosette Formation Semen/*IMMUNOLOGY Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/immunologyKWDcytotoxicity,immunologichumanKWDimmunetolerancelymphocyteculturetest,mixedKWDlymphocytetransformationmalerosetteformationsemen/KWDimmunologysupport,non-uKWDsKWDgov'tjournalarticle
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M8610100

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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