Phenotypic and functional correlations in circulating lymphocytes of prodromal homosexuals and patients with AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Phenotypic and functional correlations in circulating lymphocytes of prodromal homosexuals and patients with AIDS.

J Clin Lab Immunol. 1985 May;17(1):7-11. Unique Identifier : AIDSLINE MED/86011487
Tsang PH; Warner N; Bekesi JG

Abstract: Findings of selected phenotypic and functional parameters demonstrated significant aberrations in both prodromal homosexual males and patients with AIDS. An impaired blastogenic response to T-cell dependent B-cell mitogen was associated with a significant decrease in percentage of helper T cells but appeared unrelated to the percentage of suppressor T cells. The functional subsets of the latter were further defined by a panel of monoclonal antibodies (Leu8, Leu15, and HLA-DR) applying dual color flow cytometric techniques. In both homosexuals at risk and in AIDS patients, activated suppressor cells with the phenotype Leu2+Leu15+ and Leu2+HLA-DR+ were elevated while the reciprocal cytotoxic Ts cells (Leu2+Leu15- and Leu2+HLA-DR-) were depressed. Both subsets of suppressor precursor cells and effector cells (Leu2+Leu8+ and Leu2+Leu8-) were elevated particularly in high risk homosexual males. These results suggest a defective feedback loop that regulate both helper and suppressor T cells as well as B-lymphocyte functions and may explain the clinical manifestation of AIDS.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Adult Antibodies, Monoclonal/IMMUNOLOGY Comparative Study Feedback *Homosexuality Human In Vitro Lymphocyte Transformation Lymphocytes/CLASSIFICATION/*IMMUNOLOGY Male Middle Age Phenotype Support, Non-U.S. Gov't T-Lymphocytes, Cytotoxic/IMMUNOLOGY T-Lymphocytes, Helper-Inducer/IMMUNOLOGY T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyadultantibodies,monoclonal/immunologycomparativestudyfeedbackKWDhomosexualityhumaninvitrolymphocytetransformationlymphocytes/classification/KWDimmunologymalemiddleagephenotypesupport,non-uKWDsKWDgov'tt-lymphocytes,cytotoxic/immunologyt-lymphocytes,helper-inducer/immunologyt-lymphocytes,suppressor-effector/immunologyjournalarticle
860130
M8610097

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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