Washington, DC : National AudioVisual Center, General Services Administration, [1984] 1 videocassette (20 min.) : sd., col. ; 3/4 in Unique Identifier : AIDSLINE AV/8501077A
Washington, DC : American Association for the Advancement of Science, c1986 vi, 653 p. : ill (AAAS publication ; 85-23) Unique Identifier : AIDSLINE CAT/8510263
Dardenne M; Inserm U 25, Hopital Necker, Paris, France
Methods for assay of thymic hormones in human blood are reviewed, and serum levels of the thymic hormones are given for healthy subjects and for patients with various diseases. These levels have been evaluated mainly in primary or secondary immune deficiencies or in autoimmune diseases, using either a rosette assay, t
Acquired immunodeficiency syndrome (AIDS) patients (pts) always have evidence of defective cellular immunity, including lymphopenia and grossly decreased ratios of helper to suppressor T cells. Cutaneous anergy and diminished proliferative responses to mitogens and specific antigens are also often observed. The AIDS s
The clinical, experimental, diagnostic, and therapeutic aspects of pneumocystis, the most serious infection in patients with acquired immunodeficiency syndrome (AIDS), are discussed under the following headings: historical perspective; experimental models of Pneumocystis carinii infections; interactions between Pneumo
Zakowski PC; Gottlieb MS; Groopman J; Univ. of California Sch. of Medicine, Los Angeles, CA
Acquired immunodeficiency syndrome (AIDS), Kaposi s sarcoma (KS), and Pneumocystis carinii pneumonia are discussed under the following headings: major clinical findings in AIDS; KS; clinical findings in KS; pathogenesis of KS; treatment of KS; Pneumocystis carinii pneumonia; and other opportunistic infections. The maj
Quinnan GV Jr; Natl. Center for Drugs and Biologics, Div. of Virology, Office of; Biologics, Food and Drug Administration, Bethesda, MD 20205
The many interactions between cytomegalovirus ( CMV ) and host cellular immunity include some of the most clinically significant, complex, and fascinating problems in viral immunology. Most clinically important diseases caused
A 45-year-old man with a history of intravenous drug use presented with acute respiratory distress. A pulsus paradoxus of 42 mm Hg, accessory respiratory muscle use and stridor were present. Examination of the oropharynx revealed multiple 1 to 2 cm purple lesions of the gingiva and hard palate. A purple tumor mass in
Meyer PR; Ormerod LD; Osborn KG; Lowenstine LJ; Hendrickson RV; Modlin RL; Smith RE; Gardner MB; Taylor CR
Morphology and immunostaining of lymph nodes taken from rhesus monkeys and man are compared. The monkeys were inoculated with biologic materials known to transmit simian acquired immune deficiency syndrome (SAIDS) and the human biopsies were obtained from homosexual men with persistent generalized lymphadenopathy synd
The surgical pathology of the alimentary tract complications of the acquired immune deficiency syndrome (AIDS) is described and illustrated by a review of one year s material accessioned at a New York Community Hospital. Cytomegalovirus, Cryptosporidium and Mycobacterium avium-intracellulare were particularly notable
Ann Intern Med. 1985 Nov;103(5):674-8. Unique Identifier : AIDSLINE MED/86023878
Pape JW; Liautaud B; Thomas F; Mathurin JR; St. Amand MM; Boncy M; Pean V; Pamphile M; Laroche AC; Dehovitz J; et al
Two hundred twenty-nine patients in Haiti with the acquired immunodeficiency syndrome were studied between 1979 and 1984. The clinical spectrum of the syndrome in Haitians was similar in most aspects to that in patients with the disease in the United Sta
Ann Intern Med. 1985 Nov;103(5):729-33. Unique Identifier : AIDSLINE MED/86023889
Volberding PA
The clinical spectrum of the acquired immunodeficiency syndrome (AIDS) is broad and presents unique challenges to the health care system. Among the challenges are the unusual presentations, unexpected complications, psychosocial sequelae, and poor outcome of patients with the syndrome. From our experience with hundred
Ann Intern Med. 1985 Nov;103(5):755-9. Unique Identifier : AIDSLINE MED/86023894
Des Jarlais DC; Friedman SR; Hopkins W
Intravenous drug users are the second largest risk group for the acquired immunodeficiency syndrome (AIDS) and a bridge to two other groups: children and heterosexual partners. In the absence of effective treatment or vaccines, control of the epidemic among drug users will rely on efforts to reduce needle sharing. How
Ann Intern Med. 1985 Nov;103(5):760-4. Unique Identifier : AIDSLINE MED/86023895
Holland JC; Tross S
The acquired immunodeficiency syndrome (AIDS) and its related conditions are a public health problem of unprecedented proportions due to the debilitating and fatal nature of the disease, the sociocultural implications related to contagion, and its initial appearance in certain socially stigmatized groups. The ability
Ann Intern Med. 1985 Nov;103(5):765-7. Unique Identifier : AIDSLINE MED/86023896
Nichols SE
The psychosocial impact of the acquired immunodeficiency syndrome (AIDS) on patients follows the situational distress model of crisis, transitional state, and deficiency state. Repeated crises in AIDS modify this reaction, and patients may experience a final adjustment, the preparation for death. Additional psychosoci
Ann Intern Med. 1985 Nov;103(5):768-71. Unique Identifier : AIDSLINE MED/86023897
Cassens BJ
Awareness of the pertinent psychosocial dimensions of the acquired immunodeficiency syndrome (AIDS) provides researchers and clinicians with an understanding of factors impinging on their relationships with persons at risk for this disease. These observations are made from the standpoint of the American Association of
Ann Intern Med. 1985 Nov;103(5):771-3. Unique Identifier : AIDSLINE MED/86023898
Brandt EN Jr
The acquired immunodeficiency syndrome (AIDS) has spread rapidly through the high-risk population and has created fear and anxiety. The health policy implications of such a disorder are difficult to assess because the disease was totally unknown until a few years ago and because it occurs primarily in homosexual men a
Ann Intern Med. 1985 Nov;103(5):787-90. Unique Identifier : AIDSLINE MED/86023900
Steinbrook R; Lo B; Tirpack J; Dilley JW; Volberding PA
Caring for patients with the acquired immunodeficiency syndrome (AIDS) raises ethical dilemmas about when to provide life-sustaining treatments such as mechanical ventilation and cardiopulmonary resuscitation. In addition, many patients become mentally incompetent and unable to participate in decisions. Homosexual men
We studied two cases of a recently recognized systemic lymphoproliferative disease with morphological features of Castleman s disease: multicentric giant lymph node hyperplasia. Both patients developed Kaposi s sarcoma and had laboratory evidence of immune abnormalities, including reversed T4 to T8 ratios. One patient
Ki-1 is a monoclonal antibody (raised against a Hodgkin s disease-derived cell line) that, in biopsy tissue affected by Hodgkin s disease, reacts selectively with Reed-Sternberg cells. The expression of Ki-1 antigen has been analyzed by immunocytochemical techniques in a wide range of human tissue and cell samples, in
Alavaikko M; Rinne A; Jarvinen M; Hopsu-Havu VK; Meyer PR; Levine AM; Lukes RJ
One of two cases of acquired immune deficiency syndrome-related persistent generalized lymphadenopathy revealed a profoundly altered pattern of dendritic reticulum cells as demonstrated by immunoreactive acid cysteine proteinase inhibitor. The alterations could be related to totally or partially destructed lymphoid se
Int J Immunopharmacol. 1985;7(4):511-4. Unique Identifier : AIDSLINE MED/86007190
Tsang P; Lew F; O'Brien G; Selikoff IJ; Bekesi JG
Immunomodulative actions of isoprinosine were tested in 100 prodromal homosexual males and 23 patients who have been diagnosed with AIDS. All subjects showed reduced T helper cells although T suppressor cell counts were normal. Proliferative responses, particularly T cell-dependent B cell function, were severely impai
Peripheral blood mononuclear cells from patients with acquired immune deficiency syndrome proliferate poorly after stimulation with soluble mitogens. The present study was undertaken to assess the relative contributions of T lymphocytes and of plastic adherent mononuclear cells to the impaired mononuclear cell respons
Peripheral blood leukocytes (PBL) from male homosexual and heterosexual volunteers who did not have evidence of acquired immunodeficiency syndrome (AIDS) were studied for their ability to generate cytotoxic T lymphocyte (CTL) responses in vitro to allogeneic stimulator PBL from a single individual or from a pool of do
JAMA. 1985 Oct 11;254(14):1950-1. Unique Identifier : AIDSLINE MED/86011732
Rorat E; Garcia RL; Skolom J
During the last three years, bronchial washings from patients in whom Pneumocystis carinii pneumonia was clinically suspected were cytologically examined. These were predominantly cases of suspected or confirmed acquired immunodeficiency syndrome. To determine the effectiveness of cytologic diagnosis by means of a bro
Twenty-six patients with pulmonary infiltrates and suspected acquired immune deficiency syndrome (AIDS) underwent 29 fiberoptic bronchoscopies, including bronchoalveolar lavage. Seventeen of the 18 patients (94.4%) shown to have Pneumocystis carinii pneumonia were diagnosed by examination of the bronchoalveolar lavage
Post MJ; Kursunoglu SJ; Hensley GT; Chan JC; Moskowitz LB; Hoffman TA
A retrospective review of cranial CT scans obtained over a 4 year period in patients with acquired immunodeficiency syndrome (AIDS) and documented central nervous system (CNS) pathology is presented. The spectrum of diseases and the value of CT in detecting new, recurrent, and superimposed disease processes were deter
Cancer. 1985 Nov 15;56(10):2446-51. Unique Identifier : AIDSLINE MED/86002157
Kessler E
Multicentric giant lymph node hyperplasia (MGLH) is a distinct lymphoproliferative disorder, which may terminate in malignant lymphoma. The clinical features and laboratory findings of seven cases are reported here. The histologic changes in lymph nodes were those of giant lymph node hyperplasia, plasma cell type. Imm
Lymphocytopathic retroviruses have been recovered from the peripheral mononuclear cells of over 160 individuals in all segments of the population known to be at risk for developing AIDS. They have not been isolated from individuals coming from outside the risk groups. Virus has been cultured from patients with AIDS or
A 31-year-old white male homosexual was healthy until March 1984, when he developed Pneumocystis carinii pneumonia, which resolved with treatment. In April 1984 he developed fever, followed by hepatosplenomegaly, headaches, blurred vision, pancytopenia and pulmonary infiltrates. On June 11, intracytoplasmic yeast were
Bernstein LJ; Krieger BZ; Novick B; Sicklick MJ; Rubinstein A
We have followed 46 children with acquired immunodeficiency syndrome and acquired immunodeficiency syndrome-related complex. Twenty-six patients had at least one episode of serious bacterial infection. Twenty-seven episodes of sepsis were documented in 21 patients. Soft tissue infection was common in both the presence
Ann Intern Med. 1985 Nov;103(5):744-50. Unique Identifier : AIDSLINE MED/86023892
Safai B; Johnson KG; Myskowski PL; Koziner B; Yang SY; Cunningham-Rundles S; Godbold JH; Dupont B
Kaposi s sarcoma is a multifocal systemic neoplasm histologically characterized by proliferating fibroblastic and microvascular elements. Initial signs include macules, papules, or nodules on the skin or mucosal surface. Lesions are frequently found on the trunk, arms, and head and neck. In general, sites of involveme
La Via MF; Hurtubise PE; Parker JW; Rubin RH; Burdash NM; Spencer-Green G; Bishop DA; Dziurzynski B
The present study was undertaken to determine normal ranges for blood lymphocytes labeled with the monoclonal antibodies OKT3, OKT11, OKT4, and OKT8 and for the OKT4/OKT8 ratio. In addition, 26 patients with AIDS, 51 AIDS suspects, and 44 patients with infections were studied. The results of these determinations from
It was shown recently that monocytoid cells express B-cell-restricted antigens and polyclonal surface immunoglobulins, and the term monocytoid B lymphocytes (MBL) has thus been offered as a more appropriate designation. Although most commonly seen in toxoplasmic lymphadenitis, MBL have been observed in a variety of re
Ann Pathol. 1985;5(2):137-42. Unique Identifier : AIDSLINE MED/86000006
Le Tourneau A; Audouin J; Aubert JP; Denis J; Baufine-Ducrocq H; Duterque M; Diebold J
The identification of virus-like particles in the germinal centers of an AIDS-related lymph node with histological findings of group IA is reported. A 23 year-old man, intravenous drug user, presents an inversion of T helper/T suppressor cell ratio and a peripheral generalized lymphadenopathy, suggesting a diagnosis os
Immunosuppressive property of normal human seminal plasma has been demonstrated on various in vitro immune parameters such as, blast transformation of lymphocytes with Phytohemagglutinin (P), Concanavalin A and Lipopolysaccharide, E & EAC rosette formation and mixed lymphocyte culture. The immunosuppression appears
We have studied the distribution of Leu8 and Ia on T cells of the helper (T4) and suppressor (T8) phenotype in homosexual men with chronic unexplained lymphadenopathy, homosexual men with the acquired immunodeficiency syndrome (AIDS), and homosexual and heterosexual controls. Decreased numbers of helper T cells in lym
This article has reviewed the disease process and oral manifestations of AIDS. Specifically, dentists should review the medical history and perform an overall health assessment for all dental patients before treatment is rendered. Attention should be directed to the prodromal signs and symptoms of AIDS. If dental trea
Findings of selected phenotypic and functional parameters demonstrated significant aberrations in both prodromal homosexual males and patients with AIDS. An impaired blastogenic response to T-cell dependent B-cell mitogen was associated with a significant decrease in percentage of helper T cells but appeared unrelated
In order to reveal the activity of polymorphonuclear neutrophil leukocytes (PMNL) representing the first step of defence against infections, measurements of chemiluminescence (CL) were performed in patients suffering from acquired immune deficiency syndrome (AIDS), lymphadenopathy, or hemophilia. In comparison with he
An immunologic and virologic work-up was undertaken in 425 symptom-free multitransfused patients with hemophilias or hemoglobinopathies living in France . Patients were entered into five groups according to the type of blood product they received: local factor VIII, a mixture of loc
A comprehensive study was initiated to examine the immunologic status of a sample (n = 47) of the asymptomatic hemophilia A and B populations of metropolitan Atlanta and to determine if any of the abnormalities changed with time or correlated with infection by human T cell leukemia virus type III and lymphadenopathy-a
Br Med J (Clin Res Ed). 1985 Sep 14;291(6497):695-9. Unique Identifier : AIDSLINE MED/86001375
Jones P; Hamilton PJ; Bird G; Fearns M; Oxley A; Tedder R; Cheingsong-Popov R; Codd A
One hundred and forty-three multitransfused patients with hereditary haemostatic disorders were examined for evidence of disease related to the acquired immune deficiency syndrome (AIDS). Ninety-nine patients with severe haemophilia A were tested for anti-HTLV-III and 76 were found to be positive. All except one of th
Oda T; Kagimoto T; Aso N; Yamaguchi K; Tomino S; Takatsuki K
Adenosine deaminase (ADA) was assayed in plasma from 14 patients with adult T-cell leukemia (ATL) (eight with acute ATL and six with smoldering or chronic ATL), 20 male family members (ten were anti-ATLA antibody positive and the other ten negative), and 25 normal individuals. ADA activity was uniformly higher in plas
Infectious retrovirus(es) associated with the human (LAV, HTLV-III, ARV) and simian (SAIDS-1) acquired immune deficiency syndrome were compared by electron microscopy, immunofluorescence and immunoblotting techniques and by restriction endonuclease mapping of the viral genomes. The extracellular virus particles had si
Weber JN; Walker D; Engelkins H; Bain B; Harris JR
The haematological variables measured by automated full blood count in matched homosexual and heterosexual men attending a clinic for sexually transmitted diseases (STD) were compared with those of normal controls and patients infected with the human T lymphotropic virus type III (HTLV-III). Homosexual and heterosexua
Int J Cancer. 1985 Oct 15;36(4):445-51. Unique Identifier : AIDSLINE MED/86007119
Koyanagi Y; Harada S; Takahashi M; Uchino F; Yamamoto N
Previously, we reported that cells of the human T-cell lymphotropic virus type I (HTLV-I)-transformed lines MT-2 and MT-4 were extensively killed by infection with AIDS retrovirus HTLV-III. We have investigated this phenomenon more systematically using light and electron microscopy as well as immunofluorescence. The c
Thymosin fraction 5 (Thymosin) has numerous immunoregulatory activities including modulation of enzymes involved in lymphocyte maturation. The effect of Thymosin on the purine metabolic enzymes adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and 5 nucleotidase (5 NT) in null and T-enriched periphera
Thirteen patients affected with unexplained lymphoadenopathy, fever, weight loss, and diarrhea (lymphoadenopathy syndrome; LAS) were evaluated for the possible appearance of acquired immunodeficiency syndrome (AIDS) and for immunological and virological characterization. The patients belonged to categories of individu
Pilarski LM; Piotrowska-Krezolak M; Gibney DJ; Winger L; Winger C; Mant MJ; Ruether BA
The specificity repertoire of B lymphocytes from 14 multiple myeloma patients has been studied using the technique of Epstein-Barr virus (EBV) transformation of peripheral blood lymphocytes (PBL) coupled with clonal analysis by limiting dilution. We find that up to 100% of the B cells from myeloma patients undergoing
Chan HL; Su IJ; Kuo TT; Kuan YZ; Chen MJ; Shih LY; Eimoto T; Maeda Y; Kikuchi M; Takeshita M
The clinical and pathologic features of cutaneous lesions observed in three adult T cell leukemia/lymphoma (ATL) patients identified in Taiwan are described. They represent one classical case of ATL and two smoldering variants. The
Fuselier CO; Cachia VV; Wong C; Rawlinson D; Myers W; Baker ST; Lazerson A; Marcinko DE; Dollard MD; Smith RS; et al
Soft tissue malignancies represent a diagnostic and therapeutic challenge to the podiatric physician. In order to improve prognosis and increase survival rates of affected patients, prompt clinical and histologic recognition of suspect lesions is necessary. Here we present information and case reports on selected soft
In cultures of normal human lymphocytes infected with the human retrovirus HTLV-III/LAV, detectable cytoplasmic virus appears and then disappears in a proportion (1 to 10%) of cells, followed by release of virus detected by particulate reverse transcriptase activity, virus antigen assay, and infectivity titer. Virus i
Epstein JS; Frederick WR; Rook AH; Jackson L; Manischewitz JF; Mayner RE; Masur H; Enterline JC; Djeu JY; Quinnan GV Jr
To examine the defect in cellular immunity in patients with acquired immunodeficiency syndrome (AIDS), we studied in vitro lymphocyte proliferation and interferon (IFN) release in response to cytomegalovirus ( CMV ) antigen and
Retrovirus-like particles 60-85 nm in diameter were observed in the cytoplasm of hepatocytes in liver biopsies obtained during the acute and chronic phases of non-A, non-B hepatitis (NANBH) in three patients with transfusion-acquired disease. The particles appeared in dilated endoplasmic reticulum cisternae as well as
JAMA. 1985 Oct 11;254(14):1921-5. Unique Identifier : AIDSLINE MED/86011726
Levine AM; Gill PS; Meyer PR; Burkes RL; Ross R; Dworsky RD; Krailo M; Parker JW; Lukes RJ; Rasheed S
We report malignant lymphoma in 27 homosexual men, of whom 22 had high-grade lymphomas (B-cell immunoblastic sarcoma or small non-cleaved lymphoma) and five had low-grade disease. Antibody to human T-cell lymphotropic virus type III (HTLV-III) was present in 13 (87%) of 15 with high-grade lymphoma and in two (40%) of
Health care workers are caring for an increasing number of persons infected with human T-cell lymphotropic virus type III (HTLV-III), the primary etiologic agent of the acquired immunodeficiency syndrome (AIDS). We studied 361 health care and clinical laboratory personnel from institutions in several metropolitan area
Thirty-seven percent (15/41) of patients with human T-cell lymphotropic virus type III (HTLV-III) disease (acquired immunodeficiency syndrome [AIDS] or AIDS-related complex) sequentially evaluated at Walter Reed Army Medical Center, Washington, DC, acquired this infection from a partner(s) of the opposite sex. Demogra
In addition to the classical type of Kaposi s sarcoma, a new, aggressive and prognostically ominous variant occurs since 1980: the AIDS-associated Kaposi s sarcoma. This aggressive variant is associated with viral infection by the lymphotropic retrovirus HTLV-III, identical to LAV. In the U.S.A. and in Europe, this vi
Lentiviruses are a subfamily of retroviruses which have been aetiologically linked to the induction of arthritis, encephalitis, progressive pneumonia and slow neurological diseases in certain species. Relatively little is known about their genome structure, mechanisms of pathogenesis or evolutionary relationships with
Nature. 1985 Oct 3-9;317(6036):395-403. Unique Identifier : AIDSLINE MED/86014376
Wong-Staal F; Gallo RC
The first human retroviruses have been discovered during the past six years. They cause two diseases which involve disturbances of the growth of the T4 lymphocyte, a remarkably specific target cell type. This cell, which is central to the regulation of the immune system, is induced by human T-lymphotropic virus type I
Nature. 1985 Oct 3-9;317(6036):438-40. Unique Identifier : AIDSLINE MED/86014381
Johnsson A; Betsholtz C; Heldin CH; Westermark B
A clue to the molecular mechanism of neoplastic transformation was provided by the finding of a near identity in amino-acid sequence between the platelet-derived growth factor (PDGF) B-chain and a region in the transforming protein, p28sis, of simian sarcoma virus (SSV), an agent that causes sarcomas and gliomas in ex
Kaplan JE; Oleske JM; Getchell JP; Kalyanaraman VS; Minnefor AB; Zabala-Ablan M; Joshi V; Denny T; Cabradilla CD; Rogers MF; et al
Six children with the acquired immunodeficiency syndrome (AIDS) and 12 of their household contacts were investigated serologically for evidence of infection with human T-lymphotropic virus/lymphadenopathy-associated virus (HTLV-III/LAV), the presumed etiologic agent of AIDS. All six children had antibody against HTLV-
Proc Natl Acad Sci U S A. 1985 Oct;82(19):6502-6. Unique Identifier : AIDSLINE MED/86016730
Rosen CA; Sodroski JG; Haseltine WA
The location of cis-acting regulatory regions within the long terminal repeat (LTR) of the human T-cell leukemia virus type I (HTLV-1) was determined. The sequences present between nucleotides -350 and -55 (cap site +1) contain an enhancer element that is active in lymphoid and nonlymphoid cell lines. The sequences lo
Proc Natl Acad Sci U S A. 1985 Oct;82(20):7053-7. Unique Identifier : AIDSLINE MED/86016833
Kannagi M; Yetz JM; Letvin NL
The type C retrovirus simian T-lymphotropic virus type III (STLV-III) has been isolated recently from immunodeficient macaque monkeys at the New England Regional Primate Research Center. The present studies were done to define the in vitro growth characteristics of this agent. STLV-III replicates efficiently in interl
Proc Natl Acad Sci U S A. 1985 Oct;82(20):7096-100. Unique Identifier : AIDSLINE MED/86016842
Mitsuya H; Weinhold KJ; Furman PA; St. Clair MH; Lehrman SN; Gallo RC; Bolognesi D; Barry DW; Broder S
The acquired immune deficiency syndrome (AIDS) is thought to result from infection of T cells by a pathogenic human retrovirus, human T-lymphotropic virus type III (HTLV-III) or lymphadenopathy-associated virus (LAV). In this report, we describe the antiviral effects of a thymidine analogue,3 -azido-3 -deoxythymidine
Science. 1985 Oct 18;230(4723):327-30. Unique Identifier : AIDSLINE MED/86018835
Leal F; Williams LT; Robbins KC; Aaronson SA
A scheme for partial purification of biologically active v-sis-coded protein from cells transformed with simian sarcoma virus (SSV) has made possible a functional comparison of the transforming protein with platelet-derived growth factor (PDGF). The SSV-transforming gene product is capable of specifically binding PDGF
Science. 1985 Oct 25;230(4724):453-5. Unique Identifier : AIDSLINE MED/86018843
Cianciolo GJ; Copeland TD; Oroszlan S; Snyderman R
The retroviral transmembrane envelope protein p15E is immunosuppressive in that it inhibits immune responses of lymphocytes, monocytes, and macrophages. A region of p15E has been conserved among murine and feline retroviruses; a homologous region is also found in the transmembrane envelope proteins of the human retrov
Science. 1985 Nov 1;230(4725):570-3. Unique Identifier : AIDSLINE MED/86018865
Chen IS; Cann AJ; Shah NP; Gaynor RB
The mechanism of cellular transformation by the human T-cell leukemia viruses (HTLV) is thought to involve a novel gene known as the x gene. This gene is essential for HTLV replication and acts by enhancing transcription from the HTLV long terminal repeat. The HTLV x gene product may also cause aberrant transcription
Science. 1985 Nov 8;230(4726):633-9. Unique Identifier : AIDSLINE GENBANK/M11066
Leonard WJ; Depper JM; Kanehisa M; Kronke M; Peffer NJ; Svetlik PB; Sullivan M; Greene WC
The gene encoding the human interleukin-2 ( IL-2 ) receptor consists of 8 exons spanning more than 25 kilobases on chromosome 10. Exons 2 and 4 were derived from a gene duplication event and unexpectedly also are homologous to the recognition domain of human complement f
S Afr Med J. 1985 Oct 12;68(8):575-6. Unique Identifier : AIDSLINE MED/86019326
Lyons SF; McGillivray GM; Coppin AP; Schoub BD
A commercial enzyme immunoassay (EIA) kit was compared with an immunofluorescence test for the detection of antibodies directed against human T-cell lymphotropic virus type III (HTLV-III). The EIA kit is recommended for the screening of blood and plasma products only and is not suitable for diagnostic purposes because
Virology. 1985 Oct 30;146(2):272-81. Unique Identifier : AIDSLINE MED/86020617
Harada S; Koyanagi Y; Yamamoto N
Early events in the infection of the human T-lymphotropic virus type-I (HTLV-I)-positive MT-4 cell line by the acquired immune deficiency syndrome (AIDS) retrovirus HTLV-III were investigated. The virus was adsorbed completely to the cells within 60 min incubation after inoculation of the virus. Then, infected MT-4 ce
De Martino M; Quarta G; Melpignano A; Guadalupi C; Vullo C; Ferrucci M; Saimot AG; Vierucci A
Antibodies to HTLV-III have been investigated in 118 multitransfused beta-thalassemia patients. Thirteen patients (11.01%) were found to be positive; 3 of these 13 showed clinical and immunological signs of the lymphadenopathy syndrome. A retrospective study carried out on 65 sera has shown that at least 6 patients we
The human T-cell leukemia/lymphotropic virus type III (HTLV-III), the causative agent of the acquired immunodeficiency syndrome (AIDS), has been isolated from the conjunctival epithelium of a 33-year-old woman with AIDS, suggesting that an important reservoir of the virus may be the ocular surface epithelial cells. Th
Ann Intern Med. 1985 Nov;103(5):657-62. Unique Identifier : AIDSLINE MED/86023874
Curran JW
The incidence of the acquired immunodeficiency syndrome (AIDS) has continued to increase worldwide. From June 1981 to September 1985, 12 932 cases have been diagnosed and reported in the United States ; this number is expected to double during the next year. The incubation period is lon
Ann Intern Med. 1985 Nov;103(5):662-4. Unique Identifier : AIDSLINE MED/86023875
Jaffe HW; Hardy AM; Morgan WM; Darrow WW
The acquired immunodeficiency syndrome (AIDS) is a major health problem for gay men in the United States . About three fourths of all reported cases have occurred in this population, and the number is projected to double in the next year. In Manhattan and San Francisco, AIDS is now the
Ann Intern Med. 1985 Nov;103(5):665-70. Unique Identifier : AIDSLINE MED/86023876
Blattner WA; Biggar RJ; Weiss SH; Melbye M; Goedert JJ
The discovery of human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) has opened a window to the understanding of the spectrum of the acquired immunodeficiency syndrome (AIDS) and related clinical syndromes. Analysis of risk factors for seropositivity has shown that HTLV-III is transmitt
Ann Intern Med. 1985 Nov;103(5):670-4. Unique Identifier : AIDSLINE MED/86023877
Brunet JB; Ancelle RA
Through December 1984, 9932 cases of the acquired immunodeficiency syndrome have been reported, mainly from North and South America and Europe; 85% of these cases occurred in the United States . Haiti and the United States have the highest incidence r
Ann Intern Med. 1985 Nov;103(5):679-89. Unique Identifier : AIDSLINE MED/86023879
Gallo RC; Wong-Staal F
Three human T-lymphotropic viruses have been isolated and characterized in the past 5 years. The ability to culture target cells with T-cell growth factor and sensitive detection systems for the virally encoded polymerase reverse transcriptase permitted isolation of HTLV-I, which is strongly linked to the cause of adu
Ann Intern Med. 1985 Nov;103(5):689-93. Unique Identifier : AIDSLINE MED/86023880
Montagnier L
Recent data indicate that the lymphadenopathy-associated virus (LAV) is morphologically similar to animal lentiviruses, such as equine infectious anemia and visna viruses. This finding, together with the cross-reactivity of the core proteins of LAV with those of the equine infectious anemia virus and a similarity in g
Ann Intern Med. 1985 Nov;103(5):694-9. Unique Identifier : AIDSLINE MED/86023881
Levy JA; Kaminsky LS; Morrow WJ; Steimer K; Luciw P; Dina D; Hoxie J; Oshiro L
Peripheral mononuclear cells from more than 160 persons from groups at risk for the acquired immunodeficiency syndrome (AIDS) have yielded AIDS-associated retroviruses (ARV). Antibodies to ARV can also be found in these risk groups. Antibody-negative, virus-positive persons have been identified with early infection or
Ann Intern Med. 1985 Nov;103(5):700-3. Unique Identifier : AIDSLINE MED/86023882
Essex M; Allan J; Kanki P; McLane MF; Malone G; Kitchen L; Lee TH
Antigens encoded by the gag and env genes of the human T-lymphotropic virus type III/lymphadenopathy associated virus (HTLV-III/LAV) include a p55 gag polyprotein that yields p24 as the major virus core protein, and an env gene polyprotein, gp 160, that produces gp 120, the most immunogenic protein in humans, at the a
Ann Intern Med. 1985 Nov;103(5):704-9. Unique Identifier : AIDSLINE MED/86023883
Bowen DL; Lane HC; Fauci AS
Many abnormalities of humoral and cellular immunity associated with the acquired immunodeficiency syndrome can be explained by the preferential infection of the T4 lymphocyte subset with the etiologic retrovirus. Severe alterations in specific T4 functions, such as inadequate immune responsiveness to specific antigen,
Cell-mediated immune responses to cytomegalovirus infections were studied to define mechanisms for deficient effector T-cell responses in patients with the acquired immunodeficiency syndrome (AIDS). Progressive cytomegalovirus infection is common in such patients and is accompanied
Ann Intern Med. 1985 Nov;103(5):714-8. Unique Identifier : AIDSLINE MED/86023885
Lane HC; Fauci AS
Although effective therapies are available for many of the infections and tumors that occur in patients with the acquired immunodeficiency syndrome (AIDS), no therapy exists for the underlying immunodeficiency. Three approaches used to treat this immunodeficiency have included wholescale immune replacement through lym
Over half of the persons infected with the lymphadenopathy-associated virus/human T-lymphotropic virus type III (LAV/HTLV-III), the retrovirus that causes the acquired immunodeficiency syndrome (AIDS), become persistently infected with the virus. These carriers serve as the major reservoir of infection for others. Vir
Ann Intern Med. 1985 Nov;103(5):723-6. Unique Identifier : AIDSLINE MED/86023887
Levine PH
The widespread use of coagulation factor concentrates prepared from the blood of numerous donors has doubled the life expectancy of persons with hemophilia, but parenteral exposure to alloantigens and infectious agents is not free of risk. The prevalence of the acquired immunodeficiency syndrome (AIDS) now approaches
Ann Intern Med. 1985 Nov;103(5):726-9. Unique Identifier : AIDSLINE MED/86023888
Petricciani JC
Before the discovery of the etiologic agent of the acquired immunodeficiency syndrome (AIDS), substantial epidemiologic evidence suggested that the responsible agent could be transmitted by blood and blood products such as factor VIII. The Public Health Service and the Food and Drug Administration therefore took gener
Ann Intern Med. 1985 Nov;103(5):734-7. Unique Identifier : AIDSLINE MED/86023890
Ammann AJ
The classification of the pediatric acquired immunodeficiency syndrome (AIDS) is based on epidemiologic, immunologic, and virologic data. Persons at risk include mothers who use intravenous drugs, infants who have received blood transfusions from subjects with risk factors, patients receiving factor VIII therapy, and
Ann Intern Med. 1985 Nov;103(5):738-43. Unique Identifier : AIDSLINE MED/86023891
Armstrong D; Gold JW; Dryjanski J; Whimbey E; Polsky B; Hawkins C; Brown AE; Bernard E; Kiehn TE
The microorganisms that regularly infect patients with the acquired immunodeficiency syndrome (AIDS) have become well recognized. Most take advantage of defects in T-lymphocyte function, but others, such as Streptococcus pneumoniae and Haemophilus influenzae, take advantage of B-cell defects. Still others, such as Sta
Ann Intern Med. 1985 Nov;103(5):750-5. Unique Identifier : AIDSLINE MED/86023893
Hirsch MS; Kaplan JC
Human T-lymphotropic virus type III is susceptible to attack at various sites during its replicative cycle. Inhibitors of reverse transcriptase activity, including suramin, antimoniotungstate (HPA-23), and trisodium phosphonoformate, have shown in-vitro activity against the virus in early clinical trials. Other signif
Carbone A; Manconi R; Poletti A; Tirelli U; De Paoli P; Santini G; Diodato S; Manconi PE; Grigoletto E; Santi L; et al
Lymph node biopsy specimens from 16 intravenous drug abusers with persistent generalized lymphadenopathy were evaluated by immunohistochemical methods using a panel of antisera to detect different cell populations. The 11 cases that we tested on cryostat sections showed an increased number of Leu-2a-positive cells (cy
Lymph nodes of patients symptomatically infected with the acquired immunodeficiency syndrome (AIDS) virus show a spectrum of morphologic changes ranging from marked lymphoid hyperplasia to marked lymphocytic depletion. These changes can be grouped into three distinct patterns. The type I pattern features follicular an
A new disease has recently been recognised in rural Uganda . Because the major symptoms are weight loss and diarrhoea, it is known locally as slim disease. It is strongly associated with HTLV-III infection (63 out of 71 patients) and affects females nearly as frequently as males. Th
Lancet. 1985 Oct 19;2(8460):864-5. Unique Identifier : AIDSLINE MED/86013211
Kadin ME
A hypothesis is proposed to explain the nature of the Reed-Sternberg (RS) cell and the unexpectedly common clinical associations between lymphomatoid papulosis, mycosis fungoides, and some types of Hodgkin s disease. The RS cell appears to be a lymphoblast arising from activated helper T cells. In lymphomatoid papulos
Lancet. 1985 Oct 19;2(8460):873-7. Unique Identifier : AIDSLINE MED/86013218
Mortimer PP; Parry JV; Mortimer JY
In preparation for routine anti-HTLV-III/LAV testing in the UK five commercial assays (A-E) were evaluated using 360 sera selected on clinical and epidemiological grounds. These comprised 220 specimens from blood donors, 83 specimens from patients in high-risk groups, and 57 specimens with features likely to produce f
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