[EPIDEMIOLOGY OF HEMATOSARCOMAS] NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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[EPIDEMIOLOGY OF HEMATOSARCOMAS]

Biologie des Leucemies et Hematosarcomes. Bernard A. Boumsell L, Demeocq F, Paris, Gaston Lachurie, p. 101-13, 1983.. Unique Identifier : AIDSLINE ICDB/86619845
de-The G; Laboratoire d'Epidemiologie et Immunovirologie des Tumeurs,; Facult de Medecine Alexis Carrel, Lyon, France

Abstract: The epidemiology of Burkitt's lymphoma, T-type leukemias and lymphomas, and other non-Hodgkin's lymphoma (LNH) is discussed. Burkitt's lymphoma (BL) affects children of tropical regions, particularly Africa. Cases in the west Nile district have been shown to follow a temporal-spatial distribution. This suggests an environmental factor outside of the Epstein-Barr virus (EBV). The EBV is associated with 97% of the cases of African BL. A second environmental factor in the African-type of BL may be the endemic plasmodium parasite, the causative agent of malaria. Burkitt-type lymphomas have also been reported in Europe and the US. EBV has been associated with approximately 10% of the cases in equatorial areas. It is suggested that the role of EBV in BL is one of an initiator or co-carcinogen. It is proposed that the common factor between the European and African types is a chromosomal translocation associated with chromosome 8. A clinical syndrome known as acute T-cell leukemia lymphoma (ATL) has been described in Japan. A large majority of individuals with ATL have markers of the human T-cell leukemia virus (HTLV) in tumor cells, or have antibodies against HTLV. A similar association has been found between cases of ATL and HTLV in the Antilles. In the last 25 years there has been an increase in deaths from LNH in older adults in Western countries, very frequently Mediterranean countries. Few epidemiological studies have been conducted, but increased risk of lymphoma is associated with certain congenital immunological diseases, as well as renal transplants, accompanied by immunosuppressive therapy. (33 Refs)
Keywords: Adolescence Adult Africa Aged Burkitt's Lymphoma/EPIDEMIOLOGY/ETIOLOGY Child Child, Preschool Europe Herpesvirus 4, Human Human HTLV-BLV Viruses Infant Infant, Newborn Japan Leukemia/*EPIDEMIOLOGY Lymphoma/*EPIDEMIOLOGY Lymphoma, Non-Hodgkin's/EPIDEMIOLOGY Tumor Virus Infections United States MEETING PAPER REVIEW

KWDadolescenceadultafricaagedburkitt'slymphoma/epidemiology/etiologychildchild,preschooleuropeherpesvirus4,humanhumanhtlv-blvvirusesinfantinfant,newbornjapanleukemia/KWDepidemiologylymphoma/KWDepidemiologylymphoma,non-hodgkin's/epidemiologytumorvirusinfectionsunitedstatesmeetingpaperreview
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Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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