The immunohistology of follicle lysis in lymph node biopsies from homosexual men. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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The immunohistology of follicle lysis in lymph node biopsies from homosexual men.

Blood. 1985 Nov;66(5):1092-7. Unique Identifier : AIDSLINE MED/86026763
Wood GS; Garcia CF; Dorfman RF; Warnke RA

Abstract: Follicle lysis is a characteristic alteration of B cell follicles described recently in lymph node biopsies from homosexual men. It consists of disruption of germinal centers by aggregates of small mature lymphocytes variably associated with erythrocyte extravasation. We studied the immunohistology of follicle lysis identified in lymph node biopsies from 11 homosexual men. The results indicate that follicle lysis has two principal immunohistologic features: (1) intrafollicular aggregates of small lymphocytes predominantly of polytypic mantle B cell phenotype (T015+/Leu-8+/mu+/delta+/k+ or lambda+), and (2) disruption of the normal, unified follicular meshwork of R4/23+ dendritic reticulum cells by these B cell aggregates. These structural alterations may affect the functional integrity of the germinal center as it pertains to the abnormal B cell effector function and the increased prevalence of B cell lymphoma recently documented in the acquired immunodeficiency syndrome and related disorders. Because dendritic reticulum cells weakly express the Leu-3 (T4) antigen, which is known to be an essential component of the receptor for human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) retrovirus infection, it is possible that retroviral infection of dendritic reticulum cells may play a role in the pathogenesis of follicle lysis.
Keywords: Acquired Immunodeficiency Syndrome/PATHOLOGY Antibodies, Monoclonal/IMMUNOLOGY Antibody Specificity B-Lymphocytes/IMMUNOLOGY Flow Cytometry Homosexuality Human Lymph Nodes/*PATHOLOGY Lymphadenitis/PATHOLOGY Lymphocyte Transformation Lymphoma/PATHOLOGY Male Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/pathologyantibodies,monoclonal/immunologyantibodyspecificityb-lymphocytes/immunologyflowcytometryhomosexualityhumanlymphnodes/KWDpathologylymphadenitis/pathologylymphocytetransformationlymphoma/pathologymalesupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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M8620142

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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