[Bethesda, Md.] : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, [1985] 20 p (Literature search / National Library of Medicine ; no. 84-33) Unique Identifier : AIDSLINE CAT/8600760
Biologie des Leucemies et Hematosarcomes. Bernard A. Boumsell L, Demeocq F, Paris, Gaston Lachurie, p. 101-13, 1983.. Unique Identifier : AIDSLINE ICDB/86619845
de-The G; Laboratoire d'Epidemiologie et Immunovirologie des Tumeurs,; Facult de Medecine Alexis Carrel, Lyon, France
The epidemiology of Burkitt s lymphoma, T-type leukemias and lymphomas, and other non-Hodgkin s lymphoma (LNH) is discussed. Burkitt s lymphoma (BL) affects children of tropical regions, particularly Africa. Cases in the west Nile district have been shown to follow a temporal-spati
Whitley RJ; Dept. of Pediatrics, Univ. of Alabama Sch. of Medicine,; Birmingham, AL 45294
The epidemiology of herpes simplex virus (HSV) infections in man and historical developments, including the clinical and social significance of these infections, are reviewed. Although HSV-1 and HSV-2 are usually transmitted by different routes and involve different areas of the body (HSV-1 above the waist and HSV-2 b
Although there is no indication that the Acquired Immunodeficiency Syndrome is a health hazard to hospital personnel, precautions should be taken to prevent inanimate objects and surfaces from becoming contaminated during the autopsy of a victim of AIDS. A third person should act as circulator, the author advises, and
Pediatr Med Chir. 1983 Sep-Oct;5(5):403-6. Unique Identifier : AIDSLINE MED/86042219
Patane R; Bottaro G; Ricca O; Prestia V; Sciacca A
Three cases of Kaposi s Varicelliform Eruption are reported. In all cases the herpes virus simplex etiology was demonstrated. Every patients had in the anamnesis clinical signs of atopy. The findings in all patients of depressed cell-mediated immunity confirmed a minimal immunodeficiency as cause of atopy. The course
Between January of 1981 and June of 1984, 53 infants and children with the diagnosis of AIDS were seen at our institution. Twenty-one of these patients have required 35 operations to determine or administer the proper therapy. We have taken every precaution to minimize the risks of exposure of all health care personne
Tsai CC; Giddens WE Jr; Morton WR; Rosenkranz SL; Ochs HD; Benveniste RE
At the University of Washington Regional Primate Research Center, a simian acquired immunodeficiency syndrome (SAIDS) associated with retroperitoneal fibromatosis (RF) has been observed in 82 macaques since 1976, including 77 pigtailed macaques (Macaca nemestrina), two long-tailed macaques (M. fascicularis), one Japan
Galluccio L; Reverberi R; Castellani A; Ferrari L; Ferrari R; Moretti M; Menini C
An enzyme-linked antiglobulin test (ELAT) is described. All reagents are commercially available. The antiglobulin reagent is a monoclonal anti-IgG conjugated with alkaline phosphatase. The substrate (p-nitrophenylphosphate) is stable and innocuous. The procedure requires long incubations, particularly between red cell
During the summer of 1981 reports of unusual opportunistic infections among male homosexuals first began to appear in the literature and by December 1983, 3000 cases has been reported to the Center for Disease Control in Atlanta, Georgia. Homosexual and bisexual men comprise 71% of the reported cases, while 17% are kn
Tumori. 1985 Oct 31;71(5):501-7. Unique Identifier : AIDSLINE MED/86045316
Casadei GP; Gambacorta M
Seven cases of primary non-Hodgkin s lymphomas of the central nervous system are described. Six cases were diagnosed after pathologic examination of surgical material; in one case, a patient with acquired immunodeficiency syndrome, the diagnosis was made at autopsy. The mean age of the patients was 52 years. The lesio
Ultrastructural studies have made significant contributions in evaluating the pathology and pathogenesis of AIDS. Three distinct types of abnormal cytomembranous inclusions in tissue specimens or peripheral blood mononuclear cells from AIDS patients are described--vesicular rosettes (VR), tubuloreticular inclusions (T
A 26-year-old-old male patient with aids (acquired Immune Deficiency Syndrome) and diffuse Kaposi s sarcoma (KS) infiltration of both lungs received bilateral pulmonary irradiation. The patient received 1,600 rad in 10 treatments to the left lung, followed by a 2-week rest period, followed by 1,800 rad in 10 treatment
Granulomas were found in 16 biopsied specimens from eight patients with the acquired immune deficiency syndrome (AIDS), a disease characterized by a profound suppression of the T-cell arm of immunity. The pathogens were Mycobacterium avium-intracellulare (1), Mycobacterium tuberculosis (3), Histoplasma capsulatum (2),
One hundred random lymphocytes in each of 168 buffy coat preparations from 59 subjects at risk for AIDS (50 homosexuals, 7 hemophiliacs, and 2 combined, all with T4:T8 ratios of less than or equal to 1.2) were screened for the presence of ultrastructural markers, tubuloreticular structures (TRS), and test tube and rin
The type D retrovirus PMFV, derived from a human cell line, suppresses the in vitro response of human lymphocytes to different T-cell mitogens as well as the mixed lymphocyte reaction. The suppressive effect is virus-specific and the active fraction copurifies with the virus particles. The suppression is produced by b
Z Hautkr. 1985 Sep 15;60(18):1419-31. Unique Identifier : AIDSLINE MED/86046433
Luger A; Holmes KK
A new generation of sexually transmissible diseases affects the individual by severe long lasting complications and requires public health measures. The danger for the fetus and the newborn of perinatal transmission, the risk for pregnant women of complications before, at, and after birth, as well as the evidence of c
Cancer. 1985 Dec 15;56(12):2831-42. Unique Identifier : AIDSLINE MED/86027689
Ioachim HL; Cooper MC; Hellman GC
An increased incidence of lymphoid neoplasias is associated with the states of immune deficiency, both congenital and acquired. Twenty-one cases of lymphoma in men at high risk for Acquired Immune Deficiency Syndrome (AIDS) were diagnosed in one community hospital in New York City within the last 2 years. The mean age
A 42-year-old man who used intravenous drugs had oral candidiasis and weight loss. Careful examination led to a diagnosis of AIDS. The patient subsequently died of disseminated cryptococcosis, systemic candidiasis, and polymicrobial bacteremia. The circumstances and progression noted in this case led to the recommenda
Follicle lysis is a characteristic alteration of B cell follicles described recently in lymph node biopsies from homosexual men. It consists of disruption of germinal centers by aggregates of small mature lymphocytes variably associated with erythrocyte extravasation. We studied the immunohistology of follicle lysis i
Four fatal and two non-fatal cases of pneumonia caused by Pneumocystis carinii and one case of co-trimoxazole-responsive interstitial pneumonia, all in homosexual patients with the acquired immune deficiency syndrome, are described. The lack of clinical signs in the chest and of abnormal radiological findings at prese
Lipstein-Kresch E; Isenberg HD; Singer C; Cooke O; Greenwald RA
Patients with the acquired immune deficiency syndrome are susceptible to a wide spectrum of opportunistic infections. We report a 34-year-old man who developed systemic sporotrichosis involving the skin and joints, and whose illness terminated in subacute encephalopathy and Pneumocystis carinii pneumonia. Fungal arthr
The liver-spleen scintigrams of eight patients with the acquired immunodeficiency syndrome (AIDS) were reviewed to characterize the abnormal findings and to assess the diagnostic utility of scintigraphy in evaluating these patients for hepatic and splenic disease. Hepatosplenomegaly was present on the scintigrams of s
We encountered two cases of fatal respiratory syncytial virus infection in infants. Both patients had severe anatomic abnormalities in the thymus, probably due to severe combined immunodeficiency syndrome.
The cyst forms of Pneumocystis carinii in specimens stained with methenamine silver contain single or paired discrete foci of enhanced staining that measure 1-2 micron in maximum size. The nature of these foci and their location within the cysts have been disputed. We demonstrate by electron microscopy of silver-stain
Tuazon CU; Delaney MD; Simon GL; Witorsch P; Varma VM
Twenty patients with the acquired immune deficiency syndrome (AIDS) and suspected Pneumocystis carinii pneumonia were evaluated by gallium67 (Ga67 scintigraphy and fiberoptic bronchoscopy for initial diagnosis and response to therapy. Lung uptake of Ga67 was demonstrated in 100% of AIDS patients with P. carinii pneumo
The chemistry, antiprotozoal activity, pharmacology, clinical efficacy, adverse effects, dosage, administration, and hospital formulary considerations of pentamidine isethionate are reviewed. Pentamidine, an aromatic diamidine, has been used since the 1940s to treat a variety of protozoal infections. It is now most co
Emerg Med Clin North Am. 1985 Feb;3(1):3-23. Unique Identifier : AIDSLINE MED/86030128
Hansen RS; AhLoy RD; Meyer RD
AIDS is an apparently new condition that first occurred in about 1979 and is manifested primarily by profound disturbances of T-cell immunity and unusual susceptibility to either opportunistic infections (mycobacterial, fungal, parasitic, or viral) or tumors such as Kaposi s sarcoma and lymphoma. A prodrome of lymphad
Two micro enzyme immunoassays (microEIA) for circulating immune complexes (CICs) are described. The Raji cell microEIA was similar in sensitivity, reproducibility and specificity to the Raji radioimmunoassay. The F(ab )2 anti-C3 microEIA was comparable to the 2 Raji cell assays. The 2 microEIAs for CICs were used to a
Three cases of extrapulmonary tuberculosis are presented. Retroperitoneal and periportal adenopathy were the major manifestation of the disease detected by ultrasonography in all three cases. All of the patients were subsequently diagnosed as having acquired immunodeficiency syndrome (AIDS). The lymphohematogenous dis
Adrenal pathology was examined in 41 autopsied patients with the acquired immune deficiency syndrome. This represents the largest series and the first study with quantitation of adrenal cortical necrosis. In 32 cases clinical data were analyzed for features of adrenal insufficiency. Common clinical findings included v
Nadelman RB; Mathur-Wagh U; Yancovitz SR; Mildvan D
Six cases of bacteremia due to serotypes of Salmonella enteritidis are described in patients with the acquired immunodeficiency syndrome (AIDS). In four instances the bacteremia was recurrent despite appropriate antimicrobial treatment. Neither a gastrointestinal tract source nor any other focus of infection could be
Br Med J (Clin Res Ed). 1985 Sep 28;291(6499):849-50. Unique Identifier : AIDSLINE MED/86027011
Doble N; Hykin P; Shaw R; Keal EE
A case of pulmonary infection with Mycobacterium tuberculosis in a patient with the acquired immune deficiency syndrome (AIDS) was studied. Diagnosis of AIDS was confirmed by the finding of pulmonary M tuberculosis with oral and oesophageal candidiasis accompanied by characteristic immunological changes with evidence
Comparison of idiopathic Kaposi s sarcoma in Europe and Africa and Kaposi s sarcoma in connection with AIDS shows an identical morphological appearance in all three types. Ultrastructural and immunohistological investigations indicate that the tumour originates from the endothelial cells of proliferating capillaries a
The Acquired Immunodeficiency Syndrome (AIDS) is a disease found primarily in homosexual men, consisting of opportunistic infections and tumors, and is due to an acquired T-cell defect. In the present report, we studied various T-cell functions which might serve to distinguish homosexuals with a symptom complex includ
Burst promoting activity (BPA) and colony stimulating activity (CSA) were measured in the supernatants from six T-cell lines which are IL-2 independent and do not excrete human T-cell leukaemia virus. Two cell lines were shown to produce high levels of BPA, namely MLA-
Erfle V; Hehlmann R; Mellert W; Goebel FD; Rasokat H; Lechler E; Hellstern P; Kohler M; Seifried E; Heimpel H
The prevalence of antibodies to human T-lymphotropic virus III (HTLV-III) was determined in a total of 140 hemophiliacs and 36 polytransfused patients from three medical centers by an enzyme linked immunosorbent assay (ELISA) and confirmatory tests. 58 hemophiliacs (41.4%) were seropositive. In all instances where the
Br Med J (Clin Res Ed). 1985 Oct 12;291(6501):997-8. Unique Identifier : AIDSLINE MED/86027074
Biggar RJ; Melbye M; Ebbesen P; Alexander S; Nielsen JO; Sarin P; Faber V
Western blot analysis was used to document the development and changes in human T lymphotropic virus III (HTLV-III) antibody among Danish homosexual men followed longitudinally over three years. Reactivity against p15, p24, and p55 appeared earliest. After seroconversion the antibody concentration fluctuated, but in o
Pandolfi F; De Rossi G; Mariani G; Carbonari M; Ensoli B; Napolitano M; Lopez M; Mandelli F; Aiuti F
Antibodies against the human T-leukemia virus III (HTLV III) were detected by immunofluorescence in the sera of 17 out of 48 hemophiliacs (35.4%) without AIDS or ARC, frozen in 1983-84. Immunological data collected at that time were re-evaluated by separating HTLV III-positive and negative subjects. HTLV III positive
The infectious complications of the acquired immunodeficiency syndrome (AIDS) are discussed, and the conventional and nonconventional therapies used for these infections are reviewed. The infections most commonly encountered in patients with AIDS are Pneumocystis carinii pneumonia (58%), Candida esophagitis (31%), tox
We compared conventional bronchoscopic transbronchial biopsy (TBB) and bronchoalveolar lavage (BAL) with non-bronchoscopic bronchoalveolar lavage (NB-BAL) in nine patients with acquired immunodeficiency syndrome (AIDS) and bilateral lung infiltrates. NB-BAL was carried out with a control-tipped reusable catheter. In e
Clinical trials using interleukin 2 as a therapeutic immunomodulating agent in patients with acquired immunodeficiency syndrome have recently begun. In this article we present data from studies which indicate the ability of interleukin 2 in vitro to augment clinically important cytotoxic immune responses in lymphocyte
Int J Cancer. 1985 Nov 15;36(5):549-55. Unique Identifier : AIDSLINE MED/86032469
Tanaka Y; Inoi T; Tozawa H; Yamamoto N; Hinuma Y
We have prepared two new mouse monoclonal antibodies (MAbs) named TARM-34 (IgM) and TAG-34 (IgG1), that react with surface antigens of lines of human lymphocytes bearing a human T-cell leukemia virus type-I (HTLV-I). The characters of these antibodies are compared with those of anti-HTLV-1 gp21 MAb (TA-21, IgG1), anti
Int J Cancer. 1985 Nov 15;36(5):557-9. Unique Identifier : AIDSLINE MED/86032470
Manzari V; Gradilone A; Barillari G; Zani M; Collalti E; Pandolfi F; De Rossi G; Liso V; Babbo P; Robert-Guroff M; et al
Human T-cell leukemia virus (HTLV-I) infection is observed among black and Japanese populations in well-delimited endemic spots in association with a high incidence of adult T-cell leukemia (ATL). We present evidence of HTLV-I infection in two ATL patients from southeastern Italy wh
Int J Cancer. 1985 Nov 15;36(5):579-84. Unique Identifier : AIDSLINE MED/86032474
Voevodin AF; Lapin BA; Yakovleva LA; Ponomaryeva TI; Oganyan TE; Razmadze EN
The sera of lymphomatous and healthy hamadryas baboons of the main, lymphoma-prone Sukhumi stock were tested for antibodies reacting with HTLV-I antigens in the indirect immunofluorescence test. Antibodies of this specificity were found in all but one of 58 lymphomatous baboons and in 45% of 177 healthy ones. The prev
Most human T-cell lymphotropic virus type I (HTLV-I)-carrying cell lines possess high susceptibility to AIDS retrovirus. This high permissiveness was clearly correlated with the amount of OKT-4 molecules, the possible receptor for AIDS retrovirus, expressed on the cell surface of HTLV-I-bearing cell lines. However, no
Boumpas DT; Hooks JJ; Popovic M; Tsokos GC; Mann DL
B-cell lines were established as spontaneous outgrowths of cell cultures from patients with adult T-cell leukemia (ATL). Three such lines were shown to have integrated human T-cell leukemia/lymphoma virus 1 (HTLV-I) proviral sequences as well as Epstein-Barr virus (EBV) infection. Supernatant fluids from these culture
Peripheral blood leukocytes (PBL) from 18 homosexual men who did not have acquired immunodeficiency syndrome (AIDS) and from 9 heterosexual men were repetitively tested for their ability to generate HLA self-restricted cytotoxic T lymphocyte responses to influenza virus (flu-self) over a 2-yr period. The sera of the s
To test the hypothesis that deficient interleukin 2 ( IL-2 ) secretion may underlie the impaired capacity of T cells from patients with Acquired Immunodeficiency Syndrome (AIDS) and the AIDS-related complex (ARC) to generate the macrophage-activating lymphokine, gamma in
Ishida T; Yamamoto K; Omoto K; Iwanaga M; Osato T; Hinuma Y
The origin of a human retrovirus (ATLV or HTLV-I) is, at present, unknown although carriers of the virus have been found in Japan , the Caribbean basin and Africa. By means of a sero-epidemiological study, the Ainu people of Hokkaido, located in the northernmost island of Japan, were
J Med Virol. 1985 Oct;17(2):179-93. Unique Identifier : AIDSLINE MED/86036202
McCaul TF; Tovey G; Farthing CF; Gazzard B; Zuckerman AJ
A lymph node biopsy obtained from a patient with human T-cell lymphocytotropic virus III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody, presenting with an acute glandular fever-like illness, was examined by electron microscopy. Numerous pathological changes were present in the biopsy, including hypertrophy
A new serotype of simian acquired immune deficiency syndrome (SAIDS) retrovirus (type 2) belonging to the D genus of retroviruses is associated with a SAIDS occurring spontaneously in a colony of Celebes macaques (Macaca nigra) and rhesus macaques (Macaca mulatta) at the Oregon Regional Primate Research Center. This s
The DNA of adenovirus 35 (Ad35), a type recently associated with infections in immunocompromised hosts, was mapped by the use of BamHI, SmaI, PstI, EcoRI, and HpaI restriction endonucleases. In addition to standard mapping procedures, we used the in vitro adenovirus DNA replication system with origins at both physical
JAMA. 1985 Nov 8;254(18):2599-602. Unique Identifier : AIDSLINE MED/86037641
Clumeck N; Robert-Guroff M; Van de Perre P; Jennings A; Sibomana J; Demol P; Cran S; Gallo RC
T-lymphocyte subsets and human T-cell lymphotropic virus type III antibody prevalence were studied in African patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC), and in female prostitutes. African blood donors and healthy Zairian and Rwandese persons matched for age, sex, and ann
By Aug 15, 1985, one hundred ninety-four cases of possible transfusion-associated acquired immunodeficiency syndrome (AIDS) had been reported to the Centers for Disease Control. Cases received their transfusions in 30 states. Infants account for 10% of the cases, suggesting an increased susceptibility to developing AI
In the present nationwide survey, 1,040 new cases of lymphoid malignancy, in most of which expression of cell surface markers had been determined, and 243 controls for a case-control study on adult T-cell leukemia/lymphoma (ATL) and other types of lymphoid malignancies were enrolled during the two years (1982-84) from
Med Clin North Am. 1985 Jul;69(4):637-55. Unique Identifier : AIDSLINE MED/86039055
Sherertz RJ
AIDS is a new disease process with complications and management problems unlike anything ever seen before. An attempt has been made to summarize the available information about its various clinical presentations and how to manage them. Subjects covered will include associated malignancies, infections, transmissibility
N Engl J Med. 1985 Nov 28;313(22):1375-80. Unique Identifier : AIDSLINE MED/86040280
Stricker RB; Abrams DI; Corash L; Shuman MA
A syndrome of isolated immune thrombocytopenic purpura (ITP) has recently been described in homosexual men. We have identified an antiplatelet antibody in the serum of 29 of 30 homosexual men with isolated ITP. The antibody binds to a platelet membrane antigen of 25,000 daltons, and binding is effected by the F(ab)2 p
Nature. 1985 Nov 14-20;318(6042):154-60. Unique Identifier : AIDSLINE MED/86040473
Koprowski H; DeFreitas EC; Harper ME; Sandberg-Wollheim M; Sheremata WA; Robert-Guroff M; Saxinger CW; Feinberg MB; Wong-Staal F; Gallo RC
A combination of different types of data suggests that some multiple sclerosis patients respond immunologically to, and have cerebrospinal T cells containing, a retrovirus that is related to, but distinct from, the three types of human T-cell lymphotropic viruses. The role of this virus in multiple sclerosis is uncert
Progressive multifocal leukencephalopathy (PML) due to Papovavirus is usually combined with a cellular immunodeficiency as a consequence either of a neoproliferative disease or of medical treatment. In the first description of a case of PML in combination with substituted hemophilia A with no known cellular immunodefi
Parotid and whole saliva was collected from nine patients with acquired immunodeficiency syndrome (AIDS) and nine controls. Cytomegalovirus ( CMV ) was cultured from both salivary samples in six of the AIDS patients but was not present in any of the controls. In t
Science. 1985 Nov 15;230(4727):770-6. Unique Identifier : AIDSLINE MED/86044500
Weinberg RA
As many as 40 distinct oncogenes of viral and cellular origin have been identified to date. Many of these genes can be grouped into functional classes on the basis of their effects on cellular phenotype. These groupings suggest a small number of mechanisms of action of the oncogene-encoded proteins. Some data suggest
Science. 1985 Nov 15;230(4727):810-3. Unique Identifier : AIDSLINE GENBANK/K03455
Allan JS; Coligan JE; Lee TH; McLane MF; Kanki PJ; Groopman JE; Essex M
A newly identified protein from HTLV-III/LAV, the virus implicated as the etiologic agent of the acquired immune deficiency syndrome, was studied. This protein, which has a molecular weight of 27,000 (p27), was shown by amino acid sequencing to have a coding origin 3 to the env gene on the HTLV-III genome. The presen
Science. 1985 Nov 22;230(4728):949-51. Unique Identifier : AIDSLINE MED/86044520
Benn S; Rutledge R; Folks T; Gold J; Baker L; McCormick J; Feorino P; Piot P; Quinn T; Martin M
In an analysis of the genomic variation of AIDS retroviral isolates from patients living in New York, Alabama, and Zaire , restriction maps were constructed by using seven enzymes, each known to cleave the proviral DNA more than once, in conjunction with Southern blot analysis. The
Science. 1985 Nov 22;230(4728):951-4. Unique Identifier : AIDSLINE MED/86044521
Kanki PJ; Alroy J; Essex M
Present evidence suggests that the acquired immune deficiency syndrome (AIDS) emerged in Central Africa as a new disease in recent decades. This disease has recently approached epidemic proportions in many parts of the world. The etiologic agent of AIDS is believed to be the virus HTLV-III/LAV, which has been proposed
Two patients with T-cell malignancy having radiographic manifestations of generalized and localized bone demineralization are reported. One, a 53-year-old man, had marked osteoporosis and severe hypercalcemia, but no clinical evidence of leukemia throughout his illness. At autopsy there was no definite evidence of bon
Devare SG; Kim Y; Fox JL; Getchell J; Cabradilla C; Kalyanaraman VS
The 24,000-molecular-weight major internal protein (p24) and the 15,000-molecular-weight nucleic acid binding protein (p15) of human T-cell leukemia virus type II (HTLV-II) were subjected to amino acid composition and amino-terminal amino acid sequence analysis. A comparison of amino acid composition of p24 and p15 of
The simian sarcoma virus (SSV) encodes a gag-related 65,000-Da protein (SSV p65) which is not processed in SSV nonproducer cells (SSV-NP cells) (H.-J. Thiel, T. J. Matthews, E. M. Broughton, K. J. Weinhold, D. P. Bolognesi, T. Graf, and H. Beug (1981a), Virology 114, 124-131). In order to cleave SSV p65, retroviral pa
The splice acceptor site of pX gene of HTLV-I has been determined to be at base position 7301 using S1 nuclease protection analysis. This splice acceptor site is used in all HTLV-I immortalized T-cell clones studied despite variation in the abundance levels of pX mRNA. Our results confirmed the proposal by Haseltine e
de Rossi A; Aldovini A; Franchini G; Mann D; Gallo RC; Wong-Staal F
We have successfully transmitted cell-free HTLV-I to normal cord blood and peripheral blood lymphocytes and have exploited this system to study the kinetics of infection and transformation of these cells. Transmission was successful in 4 out of 23 attempts. In all 4 cases, the infected cells progressed from an initial
The major envelope glycoprotein of the causative agent of Acquired Immune Deficiency Syndrome (AIDS) lymphadenopathy-associated virus (LAV) has been identified and characterized. The glycoprotein has an apparent molecular weight of 110,000-120,000 under denaturing conditions in polyacrylamide gel electrophoresis. Upon
Watanabe T; Seiki M; Tsujimoto H; Miyoshi I; Hayami M; Yoshida M
A retrovirus highly related to human T-cell leukemia virus type I (HTLV-I) was isolated from a T-cell line established from a seropositive pig-tailed monkey and the provirus genome was molecularly cloned using HTLV-I as a probe. The monkey virus (STLV) had the genomic structure of the LTR-gag-pol-env-pX-LTR. Analysis
Hoshino H; Tanaka H; Shimotohno K; Miwa M; Akatsuka T; Odaka T
The S+L- cat kidney cell line CCC was cocultivated with lethally irradiated human lymphoid cell lines that were producing human T-cell leukemia virus type I (HTLV-I). Eight of nine S+L- CCC sublines that had been cocultivated with nine different HTLV-producing T-cell lines gave positive reactions for HTLV antigens by
Z Hautkr. 1985 Sep 15;60(18):1432-60. Unique Identifier : AIDSLINE MED/86046434
Drusin LM; Stingl G
Acquired immune deficiency syndrome (AIDS) is a new disease caused almost certainly by a transmissible agent, which is most likely a retrovirus termed HTLV-III. The disease is mainly spread by sexual, especially homosexual contact. Blood-borne transmission is another recognized form of spreading of the disease; it see
Ho DD; Sarngadharan MG; Resnick L; Dimarzoveronese F; Rota TR; Hirsch MS
Primary infection with the human T-lymphotropic virus type III (HTLV-III) was documented in three patients by virus isolation during acute illness and concurrent or subsequent HTLV-III seroconversion. All patients had fevers, rigors, arthralgias, and myalgias. Additional symptoms included truncal maculopapular rash, u
The physiology of the histiocyte (macrophage) in health and disease is reviewed briefly. An overview of the so-called primary malignant, pseudomalignant, and benign histiocytic disorders, excluding histiocytosis X, is presented. The malignant histiocytosis with erythrophagocytosis, the pseudomalignant histiocytic dise
Cancer. 1985 Nov 1;56(9):2217-20. Unique Identifier : AIDSLINE MED/86027716
Su IJ; Chan HL; Kuo TT; Eimoto T; Maeda Y; Kikuchi M; Kuan YZ; Shih LY; Chen MJ; Takeshita M
The retrovirus-associated adult T-cell leukemia/lymphoma (ATL) has not been previously documented in Taiwan . Five cases identified recently by the authors are reported. Three of the patients were women, and their ages ranged from 36
Emerg Med Clin North Am. 1985 Nov;3(4):809-28. Unique Identifier : AIDSLINE MED/86030142
Drake LA
The formulary for dermatologic use in the emergency department must not only encompass drugs that are essential for advanced cardiac and trauma life support, but must have specific drugs that are indicated for common dermatologic conditions that are evaluated in the emergency department. First and foremost is the sele
FEBS Lett. 1985 Nov 11;192(1):37-42. Unique Identifier : AIDSLINE MED/86030700
Sagata N; Yasunaga T; Ikawa Y
Human T-cell leukemia and bovine leukemia viruses have a potential transforming gene, termed X. In addition to the major open reading frame known to encode a functional protein, the X gene harbors another short open reading frame which overlaps this major one. Both of these open reading frames are found on a single sp
Lancet. 1985 Nov 16;2(8464):1083-6. Unique Identifier : AIDSLINE MED/86039316
Esteban JI; Shih JW; Tai CC; Bodner AJ; Kay JW; Alter HJ
Stored donor and recipient sera from prospective studies of post-transfusion hepatitis were analysed for the presence of human T-cell lymphotropic virus type-III/lymphadenopathy associated virus (HTLV-III/LAV) antibodies as determined by enzyme-linked immunosorbent assays (ELISA). Of 3961 donor samples given to 461 pa
Serum samples from 224 aboriginal Amazonian Indians were tested for antibodies to HTLV-III/LAV by an indirect immunofluorescence (IF) assay. 9 individuals (4%), 5 of them female, were seropositive by IF and by confirmatory western blotting and radioimmunoprecipitation tests. 3 of the positive sera were collected in 19
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