Isoprinosine effects on interleukin-1 production in acquired immune deficiency syndrome (AIDS). NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Isoprinosine effects on interleukin-1 production in acquired immune deficiency syndrome (AIDS).

Int J Immunopharmacol. 1986;8(4):437-41. Unique Identifier : AIDSLINE MED/86303177
Tsang KY; Donnelly RP; Galbraith GM; Fudenberg HH

Abstract: The in vitro effects of isoprinosine (ISO) on the production of IL-1 in AIDS patients and normal controls were investigated in this study. IL-1 production from adherent cells was measured by an indirect method using EL-4 cells. Five of eleven AIDS patients had depressed IL-1 production. Various concentrations of ISO were used to treat the adherent cells in vitro and the optimal concentration for stimulating IL-1 production was determined to be 100 micrograms/ml/10(6) cells. IL-1 production was augmented to normal or to near normal levels in four of five AIDS patients. Our results indicate that depressed immunity seen in some AIDS patients may be partly due to the depressed in IL-1 production and also that ISO can act as an immune potentiation in enhancing the production of this lymphokine in vitro.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Female Human In Vitro Inosine/*ANALOGS & DERIVATIVES Interleukin-1/*BIOSYNTHESIS Interleukin-2/ANALYSIS Isoprinosine/*PHARMACOLOGY Male Support, U.S. Gov't, P.H.S. T-Lymphocytes/CLASSIFICATION/DRUG EFFECTS/*IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyfemalehumaninvitroinosine/KWDanalogs&derivativesinterleukin-1/KWDbiosynthesisinterleukin-2/analysisisoprinosine/KWDpharmacologymalesupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/classification/drugeffects/KWDimmunologyjournalarticle
861230
M86C0157

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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