Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer.

Proc Natl Acad Sci U S A. 1986 Sep;83(17):6558-62. Unique Identifier : AIDSLINE MED/86313617
Paskalis H; Felber BK; Pavlakis GN

Abstract: Transcription from the long terminal repeat promoter of human T-cell leukemia virus type I is activated in the presence of a trans-activator protein, TA-I, encoded in the 3' part of the genome. A series of long terminal repeat mutants and hybrid promoter constructs have been studied in a transient expression assay for their ability to be activated in the presence of the trans-activator protein. The sequences responsible for trans-activation have properties similar to those of transcription enhancer elements. They act relatively independent of position and orientation and activate both the homologous as well as heterologous promoters only in the presence of the trans-activator protein. Therefore, the trans-activator protein of human T-cell leukemia virus type I acts via an inducible enhancement mechanism.
Keywords: Base Sequence Chromosome Deletion Chromosome Mapping DNA-Binding Proteins/*GENETICS *Enhancer Elements (Genetics) Gene Expression Regulation *Genes, Regulator HTLV-BLV Viruses/*GENETICS Promoter Regions (Genetics) Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Transcription Factors/*GENETICS Transcription, Genetic JOURNAL ARTICLE

KWDbasesequencechromosomedeletionchromosomemappingdna-bindingproteins/KWDgeneticsKWDenhancerelements(genetics)geneexpressionregulationKWDgenes,regulatorhtlv-blvviruses/KWDgeneticspromoterregions(genetics)support,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDtranscriptionfactors/KWDgeneticstranscription,geneticjournalarticle
861230
M86C0057

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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