Presents Columbia-Presbyterian Medical Center as a model where staff members are prepared with the facts about AIDS and CDC-recommended techniques for patient management. Demonstrates a detailed yet concise plan of action appropriated for any hospital with an AIDS patient.
[Bethesda, Md.] : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, [1985] 33, 12 p (Literature search / National Library of Medicine ; no. 85-4) Unique Identifier : AIDSLINE CAT/8611760
UCLA Symp Mol Cell Biol; New Ser 17:273-92 1984. Unique Identifier : AIDSLINE ICDB/86621896
Miller G; Dept. of Epidemiology and Public Health, Yale Univ. Sch. of; Medicine, New Haven, CT 06510
Strategies used to identify the genomic regions of Epstein-Barr virus (EBV) involved in viral latency and immortalization are described, and some clinical cases of EBV-associated polyclonal lymphomas are discussed. The primary strategy for analysis of immortalization is to identify the products and eventually, the fun
Duque E; Correa P; Blattner WA; Saxinger C; Gallo RC; Departamento de Patologia, Facultad de Salud, Universidad del; Valle, Cali, Columbia
Eleven patients with non-Hodgkin s lymphoma were tested for the presence of antibodies to human T cell leukemia virus (HTLV). The age ranged from 21 to 73 yr. There were 5 females and 6 males. Four patients were serologically positive for the presence of HTLV antibodies. Three of t
People with AIDS have great needs--not only physical due to the effects of the disease on their bodies, but psychological as well. In addition, fear and repugnance of the disease and its victims has started another epidemic dubbed AFRAIDS.
Cancer Treat Rep. 1986 Sep;70(9):1121-2. Unique Identifier : AIDSLINE MED/86298195
Kaplan L; Abrams D; Volberding P
Twenty-four patients with acquired immunodeficiency syndrome and Kaposi s sarcoma (KS) were treated with a regimen alternating vincristine with vinblastine on a weekly basis. Objective responses to this regimen were observed in nine patients (45%), and seven (35%) had stabilization of progressive KS. Few toxic effects
When candidiasis involves the esophagus, it usually does so as an extensive and diffuse infection. In our experience, however, esophageal candidiasis in patients with the acquired immunodeficiency syndrome (AIDS) is clinically distinct from the same infection in patients with other immunodeficiency states. Of 25 patie
A liquid chromatographic (LC) method is described for evaluating purity of pentamidine isethionate (PI), a life-saving drug used in the treatment of Pneumocystis carinii pneumonia, which is a leading cause of death in persons with acquired immunodeficiency syndrome (AIDS). Six potential impurity compounds were synthes
The yield in cultures of bone marrow aspirations or biopsies was determined in 50 patients with acquired immunodeficiency syndrome. Most patients were febrile and had no identifiable source of infection. Concurrent stool, urine, and blood samples were also cultured. The bone marrow aspiration and biopsy procedures pro
Farkash AE; Maccabee PJ; Sher JH; Landesman SH; Hotson G
From January 1981 to January 1983 acquired immune deficiency syndrome (AIDS) was diagnosed in 90 patients admitted to Kings County Hospital-Downstate Medical Center. CNS involvement occurred in 18 patients of whom 12 had toxoplasmosis confirmed by biopsy or necropsy. Pathological specimens from these 12 patients were
An abdominal computed tomographic examination was performed to 20 patients with Acquired Immunodeficiency Syndrome (AIDS) and to 5 patients with Lymphadenopathy Syndrome (LAS). Intraabdominal lymph nodes were seen in 18 out of 20 cases of AIDS and in 5 cases of LAS. Lymph nodes have a normal size or are slightly enlar
Mantovani G; Santa Cruz G; Piso A; Arangino V; Balestrieri A; Del Giacco GS
This report describes a case of hairy cell leukemia (HCL) with typical hematological and clinical findings. The most striking feature is the electron microscopic pattern of intracytoplasmic inclusions within hairy cells (HCs), which can be identified with the tubuloreticular inclusions , very unusual and not yet repo
Severe protein-calorie malnutrition is common in patients with AIDS (acquired immunodeficiency syndrome). These nutritional deficits are likely to further impair immune responses and other organ functions vital for recovery from serious infectious diseases. Since selenium deficiency is known to be associated with oral
Kaposi s sarcoma of the larynx is a rarely observed manifestation of AIDS. Possible concomitant symptoms are hoarseness up to aphonia, urge to cough or stridor. Expectoration of small parts of tissue of Kaposi s sarcoma may be an additional sign. Similar to Kaposi s sarcoma in the oral cavity Kaposi s sarcoma of the l
CT or postmortem examination demonstrated calcification of the basal ganglia in eight infants and children with acquired immune deficiency syndrome. Serial CT studies documented progression of both bilateral symmetric calcium densities and cerebral atrophy. Clinical features included progressive encephalopathy with
A patient with acquired immunodeficiency syndrome treated with prochlorperazine and droperidol developed neuroleptic malignant syndrome, characterized by akinetic mutism, resting tremor, cogwheel rigidity, and elevated serum creatine phosphokinase. An identical syndrome reappeared with subsequent administration of hal
An aggressive visceral form of Kaposi s sarcoma (KS) has been reported in immunosuppressed populations, most notably in patients with acquired immunodeficiency syndrome (AIDS). This presentation contrasts from the indolent skin lesions on the extremities of older males and is distinct enough in the young adult America
Injury to the gastrointestinal tract may be mediated in part by the intraepithelial lymphocyte. In this study, we utilized electron microscopy to define the morphological appearance of 86 intestinal and 55 rectal intraepithelial lymphocytes observed in 11 patients with acquired immunodeficiency syndrome (AIDS), and on
Thymic biopsy was done at the time of open lung biopsy in 11 children with acquired immunodeficiency syndrome (AIDS). Precocious involution, involution mimicking dysplasia designated as dysinvolution, and thymitis characterized by lymphomononuclear or plasmacytic infiltration, medullary lymphoid follicles, or medullar
The following recommendations have been developed by the Public Health Service of the U.S. Department of Health and Human Services who granted International Nursing Review the authorization to reproduce them. Since AIDS knows no frontier, we believe that these guidelines could be useful to health care personnel the wo
More than 25 000 serum specimens have been tested for antibody to human T-lymphotropic virus type III (HTLV-III) at the Laboratory Centre for Disease Control, Ottawa, since August 1984. In 1985 the prevalence rates of antibody positivity among selected risk groups were as follows: patients with Kaposi s sarcoma, 77%;
Am Fam Physician. 1986 Aug;34(2):114-8. Unique Identifier : AIDSLINE MED/86319830
Feder HM Jr; Schmidt P
Children or adults with AIDS may be seen first by family physicians, who must be aware of the epidemiology, signs and symptoms, and initial laboratory evaluation of these patients. Numerous complications are to be expected. The physician can provide reassurance that AIDS is not transmitted through casual contact, can
Am J Med Sci. 1986 Sep;292(3):142-6. Unique Identifier : AIDSLINE MED/86320392
Andes WA; Wulff KM; Mercer D; Frempong KO; Patin J
A prospective evaluation of 115 patients with hemophilia was performed between July 1982 and July 1983. During that period, 24 patients were seen with unexplained, generalized lymph node enlargement. The date lymphadenopathy occurred was recorded. No lymphadenopathy was found in 22 patients who did not receive coagula
Int J Immunopharmacol. 1986;8(4):437-41. Unique Identifier : AIDSLINE MED/86303177
Tsang KY; Donnelly RP; Galbraith GM; Fudenberg HH
The in vitro effects of isoprinosine (ISO) on the production of IL-1 in AIDS patients and normal controls were investigated in this study. IL-1 production from adherent cells was measured by an indirect method using EL-4 cells. Five of eleven AIDS patients had depressed IL-1 production. Various concentrations of ISO w
Interleukin 1 secretion from human alveolar macrophages was studied in patients with interstitial pulmonary fibrosis, sarcoidosis, and the acquired immunodeficiency syndrome with pneumonitis and compared to secretion from alveolar macrophages of normal volunteers. Macrophages lavaged from the lungs were stimulated wit
The livers of 26 adult males with acquired immune deficiency syndrome (AIDS) were reviewed. The occurrence of portal tracts with diminished lymphocytes, probably reflecting generalized exhaustion of the lymphoid system, was a characteristic morphologic change, and was found in all cases. Kupffer cell hyperplasia was a
Seventy five patients with pulmonary disease and suspected acquired immune deficiency syndrome (AIDS) underwent fibreoptic bronchoscopy with bronchoalveolar lavage. Of 54 cases of Pneumocystis carinii pneumonia, 53 (98%) were diagnosed by bronchoalveolar lavage. Complications were recorded in 12 instances and included
CT findings of 15 patients with histologically proven primary central nervous system (CNS) lymphoma were reviewed with pathologic correlation in order to evaluate variable CT patterns. There were a total of 32 lesions. Of the 15 patients studied, seven had acquired immunodeficiency syndrome (AIDS), all diagnosed withi
Two patients with acquired immunodeficiency syndrome developed spontaneous pneumothorax during the course of Pneumocystis carinii pneumonia. The pneumothorax in each of these patients was a primary event, unrelated to biopsy or mechanical ventilation. To our knowledge, this complication of P carinii infection has not
Crit Care Med. 1986 Sep;14(9):819-27. Unique Identifier : AIDSLINE MED/86299664
Layon J; Warzynski M; Idris A
The acquired immunodeficiency syndrome (AIDS) epidemic shows no sign of waning. Recent calculations suggest that several hundred thousand asymptomatic people may have been infected with the putative AIDS agent, HTLV-III/LAV. This review includes an analysis of immunologic data, means of preventing transmission of the
Medicine (Baltimore). 1986 Sep;65(5):312-21. Unique Identifier : AIDSLINE MED/86310224
Ampel NM; Ryan KJ; Carry PJ; Wieden MA; Schifman RB
Sixteen episodes of fungemia due to Coccidioides immitis were identified in 15 patients over a 7-year period at 2 hospital associated with the University of Arizona in Tucson. Fourteen of the 15 patients were male and 13 had an underlying condition, including malignancy in 6 and AIDS in 3. Ten of the patients were rec
A micromethod of indirect immunofluorescence with monoclonal antibodies to study surface markers of leukocytes and precursors, is described. This method consists of attaching non specifically living cells on a slide, previously treated with a high molecular weight polymer (L-lysin). The advantage of this method consis
South Med J. 1986 Sep;79(9):1070-5. Unique Identifier : AIDSLINE MED/86316078
Khojasteh A; Reynolds RD; Khojasteh CA
Reports of high-grade non-Hodgkin s lymphoma , Hodgkin s disease, and lymphocytic leukemia in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-like immune disorders have been increasing. In some cases, histologic alterations of lymph node architecture may precede the
Br Med J (Clin Res Ed). 1986 Aug 23;293(6545):489-92. Unique Identifier : AIDSLINE MED/86297481
Johnson AM; Adler MW; Crown JM
The epidemic of the acquired immune deficiency syndrome (AIDS) and infection with human immunodeficiency virus (HIV) necessitates early planning of services and allocation of resources. The use of hospital resources by patients with AIDS and the planned additional costs of clinical and preventive services for the epid
Schuurman HJ; Hendriks RW; Lange JM; van der Linden JA; Gmelig Meyling FH; Danner SA; Kater L
We investigated the in vitro effect of cultured human thymic epithelial monolayer cells on mononuclear cells (MNC) from patients with Acquired Immune Deficiency Syndrome (AIDS) and AIDS-related complex (ARC). Patients having undergone bone-marrow transplantation (BMT), who showed a similar deficiency of T-lymphocytes
Each immunoglobulin G (IgG) subclass has unique physicochemical properties and, probably, unique functions. Each heavy chain is coded by a separate gene on chromosome 14. Deficient synthesis of a subclass may be associated with recurrent or chronic infections, the deficiency not being detected by measurements of level
Eighty-one homosexual patients positive for HTLV-III antibody, including 19 with AIDS, 20 with chronic lymphadenopathy syndrome, 10 with AIDS-related complex (ARC) and 32 symptom-free individuals were assessed for the presence of cold agglutinins (CA). In 12 cases, CA were found; 4, 4, 2 and 2, respectively, in each o
Pekovic DD; Chausseau JP; Lapointe N; Michaud J; Garzon S; Strykowski H; Tsoukas C; Gilmore N; Goldman H; Gornitsky M; et al
HTLV-III was searched for in frozen sections of peripheral blood lymphocytes obtained from AIDS patients by an immunofluorescence technique. Human IgG against HTLV-III/LAV and monoclonal antibodies against HTLV-III/LAV P 24 antigen, yielded a strong cytoplasmic fluorescence in frozen sections of the lymphocytes. Some
Shohat B; Joshua H; Delpre G; Geller E; Blum I; Theodor E; Trainin N
Markers and functions of T cell subsets were studied in 3 Israeli males suffering from AIDS, two of whom were homosexuals and one heterosexual developing AIDS after a coronary bypass operation followed by multiple blood transfusions. Two healthy homosexual partners of one of the AIDS patients were also studied. Sera f
Translation, packaging and reverse transcription of the genomic RNA of retroviruses appear to be regulated by short and long range RNA-RNA interactions which take place within the 5 -600 nt and between the 5 and 3 untranslated sequences. The 5 (R and U5) and 3 (Dr and U3) domains of the genomic RNA together with t
Cancer. 1986 Oct 1;58(7):1583-4. Unique Identifier : AIDSLINE MED/86298127
Blayney DW; Ito JI; Jensen FC
Kaposi s sarcoma (KS) in homosexual men has been linked to the acquired immune deficiency syndrome (AIDS). We describe a 51-year-old homosexual man who developed extremity KS while taking corticosteroids. The KS resolved when the steroids were withdrawn. He did not have classically defined AIDS: no evidence of HTLV-II
A comprehensive evaluation of the cellular immune system (total T-cell, helper cell, suppressor cell, and natural killer cell numbers; in vitro interleukin-2 production, T-cell responses to mitogens and antigens, serum beta 2 microglobulin levels, and delayed hypersensitivity skin tests) was performed on 36 HTLV-III s
In addition to T cell abnormalities, patients with haemophilia A show a separate B cell dysfunction. Characteristic are elevated spontaneous IgG (not IgM) levels in the patient s sera and in the culture supernatants of peripheral blood mononuclear cells. It is also observed that these cells fail to show a differentiat
Kimmig W; Mensing H; Seyfarth K; Schaeg G; Janner M; Nasemann T
Epstein-Barr virus was demonstrated electronmicroscopically in a leucoplakic area of the tongue of a man infected with HTLV-III/LAV. Oral hairy leucoplakia, diagnosed from the clinical findings, histology and by electronmicroscopy, in this patients is to be interpreted as the initial sign of an HTLV-III/LAV infection.
EMBO J. 1986 Jul;5(7):1535-41. Unique Identifier : AIDSLINE MED/86300653
Johnsson A; Betsholtz C; Heldin CH; Westermark B
Previous studies have indicated that the oncogene v-sis of simian sarcoma virus (SSV) encodes a growth factor that is structurally and functionally similar to platelet-derived growth factor (PDGF). In the present investigation we have analysed the phenotypic characteristics of human foreskin fibroblasts transformed by
We report here a case of cutaneous molluscum contagiosum infection, which led to the diagnosis of HTL V III infection. Profuse mollusca contagiosa are one of the cutaneous lesions indicating the presence of AIDS at any stage.
Frager DH; Frager JD; Wolf EL; Rand LG; St. Onge G; Mitsudo S; Bodner L; Brandt LJ; Beneventano TC
Six cases of cytomegalovirus ( CMV ) colitis are described. The radiographic manifestations of this colitis are nonspecific and usually mimic the findings of ulcerative colitis with diffuse mucosal ulceration or granulomatous c
Fontana L; Sirianni MC; de Sanctis G; Carbonari M; Ensoli B; Aiuti F
Blood lymphocytes (BL) of eleven patients with lymphoadenopathy syndrome (LAS) were studied for natural killer (NK) activity against the K562 cell line (using both the standard 51Cr release assay and the single-cell cytotoxicity assay on poly-L-lysine-coated coverslips) and for surface phenotype (employing OKT4, OKT8
Effect of human interferon gamma (rINF gamma) on HTLV-III replication was evaluated quantitatively via a novel infection system using HTLV-I-carrying MT-4 cells. Treatment of HTLV-III-infected MT-4 cells with different concentrations (I-1,000 U/ml) of rINF gamma, which did not affect the growth or viability of uninfec
AIDS developed in a blood donor-recipient pair in Israel . Transmission of HTLV III/LAV probably occurred via a blood transfusion in November 1979. The donor was asymptomatic at the time of blood donation, but initial symptoms of AIDS-related complex developed in the donor 3 months
Maskill W; Healey D; Wootten A; Silvester C; Johnson S; O'Dwyer C; Jacklin R; Pringle R; Gust I; Harden P; et al
The sensitivity, specificity and reproducibility of an enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to LAV/HTLV III produced by Genetic Systems was assessed with the identical panel of sera used in previous evaluations of anti-HTLV III ELISAs. The results from this study show that the Gene
The results of clinical and Epstein-Barr virus (EBV) serological studies on nine Chediak-Higashi syndrome (CHS) patients are reported. Persistently elevated antibodies to the viral capsid antigen (VCA) and the restricted component of the early antigen complex (EA-R) developed in six patients who experienced primary EB
Homosexual men were studied for associations among human T-lymphotropic virus type III (HTLV-III) infection, Epstein-Barr virus (EBV) infection, and T cell abnormalities. The presence of IgG antibody to EBV capsid antigen and antibody to EBV early antigen was significantly associated with augmented counts of suppresso
J Med Virol. 1986 Aug;19(4):325-34. Unique Identifier : AIDSLINE MED/86306686
Hedenskog M; Dewhurst S; Ludvigsen C; Sinangil F; Rodriguez L; Wu YT; Volsky DJ
Seropositivity to the AIDS-associated retrovirus, HTLV-III/LAV, has profound implications. Simple and reliable tests are needed to detect such antibodies. A rapid, sensitive indirect immunofluorescence assay (IFA) on acetone-fixed virus-producing CEM/LAV-N1 cells was adapted for detection of human antibodies to HTLV-I
LAV/HTLV-III/AAV viruses were isolated from 20 German patients with ARC/AIDS in order to investigate strain variation. Virus was isolated from the peripheral blood and/or cerebrospinal fluid (CSF) in umbilical cord peripheral blood lymphocyte (PBL) cultures. Isolates were identified by their cytopathic effect (CPE), b
J Med Virol. 1986 Aug;19(4):387-97. Unique Identifier : AIDSLINE MED/86306692
Parry JV
An immunoglobulin G (IgG) antibody capture assay (GACRIA) methodologically distinct from other assays for the detection of antibodies to human T-lymphotropic virus type III/lymphadenopathy-associated virus (anti-HTLV III/LAV) was developed and used to test 1,055 serum samples previously screened by a competitive assay
Twenty-five children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex had a characteristic pattern of T cell deficiency. Abnormally low plasma thymulin levels preceded the development of peripheral blood T cell abnormalities. In contrast to patients with congenital T cell deficiencies, our patie
JAMA. 1986 Oct 3;256(13):1758-62. Unique Identifier : AIDSLINE MED/86308357
Jason J; Holman RC; Dixon G; Lawrence DN; Bozeman LH; Chorba TL; Tregillus L; Evatt BL
We compared recipients of eight lots of factors VIII and IX voluntarily withdrawn from distribution because one donor was known to have subsequently developed the acquired immunodeficiency syndrome with a nonexposed cohort matched by age, sex, and factor use. The factor VIII recipient cohorts did not differ in prevale
JAMA. 1986 Oct 3;256(13):1768-74. Unique Identifier : AIDSLINE MED/86308359
Bayer R; Levine C; Wolf SM
We believe that the greatest hope for stopping the spread of HIV infection lies in the voluntary cooperation of those at higher risk--their willingness to undergo testing and to alter their personal behavior and goals in the interests of the community. But we can expect this voluntary cooperation--in some cases, sacri
Gan No Rinsho. 1986 Jul;32(8):940-4. Unique Identifier : AIDSLINE MED/86308491
Saigo K; Wakuya J; Ueda K; Yoshida Y; Ryo R; Yamaguchi N
A patient with adult T cell leukemia (ATL) whose chief complaint was marked swelling of left thigh is reported. A 72-year-old woman was diagnosed as having ATL based on a high titer of anti-ATLA antibody and abnormal lymphocytes with convoluted nuclei. Computed tomography revealed swelling of her left thigh and a larg
Gan No Rinsho. 1986 Aug;32(9):1011-4. Unique Identifier : AIDSLINE MED/86308495
Inoue F; Furukawa H; Uchino H
An autopsy case of ATL with acute hepatic failure is reported. A 39-year-old man born in Miyazaki Prefecture was admitted because of jaundice and general malaise of about 10 days duration. Palpation of the abdomen revealed moderate hepatomegaly: the patient had clear consciousness. The white cell count was 62,500/mm3
Using the DNA-binding fluorochrome, DAPI, spermatozoa and Pneumocystis carinii were easily demonstrated in postmortem lung sections of an AIDS patient. The possible practical significance of these findings is discussed.
An investigation for HTLV-III antibodies in chronic hemodialysis patients revealed in four out of 276 patients a positive result using the ELISA and western blot techniques. All HTLV-III positive patients had received blood transfusions. As it has been shown that a needle stick could transmit the HTLV-III, it is sugge
Sera from each of five preselected groups of patients with acquired immune deficiency syndrome (AIDS), AIDS-related complex (ARC), hemophilia, adult T-cell leukemia (ATL), and healthy controls were examined for antibodies to human T-cell leukemia (T-lymphotropic) virus type-I (HTLV-I) and HTLV-III by indirect immunofl
The budding process and fine structure of lymphadenopathy-associated virus (LAV), were studied by indirect immunofluorescence (IF) and electron microscopy (EM). By IF, LAV antigen was seen to be distributed focally within infected CCRF-CEM cells. Consistent with this finding, electron micrographs showed that LAV parti
Eiden M; Newman M; Fisher AG; Mann DL; Howley PM; Reitz MS
In an attempt to express the small (transmembrane) envelope protein p21e of type 1 human T-cell leukemia (lymphotrophic) virus (HTLV-1) exclusive of other viral gene products, we have constructed a recombinant plasmid clone (pMBE-1) in a bovine papillomavirus-derived mammalian expression vector. Mouse C127 cells trans
Four patients with the acquired immunodeficiency syndrome and Kaposi s sarcoma were treated with subcutaneous human recombinant gamma-interferon at a dosage of 200 micrograms = 2 X 10(6) U twice daily for at least 28 days. While the dosage of interferon was well tolerated, progressive disease was observed in all four
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6440-4. Unique Identifier : AIDSLINE MED/86313594
Betsholtz C; Johnsson A; Heldin CH; Westermark B
Simian sarcoma virus, an acutely transforming primate retrovirus with capacity to induce gliomas and sarcomas in experimental animals, has acquired its transforming properties by transducing the cellular gene sequences that encode one of the constituent chains of platelet-derived growth factor. Suramin, a drug used in
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6558-62. Unique Identifier : AIDSLINE MED/86313617
Paskalis H; Felber BK; Pavlakis GN
Transcription from the long terminal repeat promoter of human T-cell leukemia virus type I is activated in the presence of a trans-activator protein, TA-I, encoded in the 3 part of the genome. A series of long terminal repeat mutants and hybrid promoter constructs have been studied in a transient expression assay for
Proc Natl Acad Sci U S A. 1986 Sep;83(18):6672-6. Unique Identifier : AIDSLINE GENBANK/M14310
Aldovini A; Debouck C; Feinberg MB; Rosenberg M; Arya SK; Wong-Staal F
Human T-lymphotropic virus type III (HTLV-III) contains a gene (tat-III) the product of which activates the expression of viral genes in trans. We have expressed in Escherichia coli the complete tat-III-encoded protein as well as a truncated form that lacks three amino acids from the amino terminus. These proteins are
This study initiates an effort to develop a safe vaccine against the acquired immunodeficiency syndrome (AIDS) that is caused by infection with a retrovirus designated human immunodeficiency virus (HIV) [formerly human T-cell lymphotropic virus type III (HTLV-III)]. Other retrovirus models have shown that purified ext
Proc Natl Acad Sci U S A. 1986 Sep;83(18):7089-93. Unique Identifier : AIDSLINE MED/86313715
Wiley CA; Schrier RD; Nelson JA; Lampert PW; Oldstone MB
Dysfunction of the central nervous system (CNS) is a prominent feature of the acquired immune deficiency syndrome (AIDS). Many of these patients have a subacute encephalitis consistent with a viral infection of the CNS. We studied the brains of 12 AIDS patients using in situ hybridization to identify human immunodefic
This report describes the experience with Argon laser used in an attempt to slow the advance of CMV retinitis in two eyes of two patients with AIDS, who were not able to be treated with antiviral chemotherapy. The treatment was performed to create a retinal scar
We have identified a recombinant leporipoxvirus that produces disseminated fibromas and a severe combined immune deficiency disease of sudden onset. The virus is recombinant between the SFV and the MV. MV was identified as a trace contaminant in stocks of SFV (Patuxent strain). Rabbits inoculated with the original unc
Hepatitis A and hepatitis B are viral infections of the liver. Hepatitis A is spread by the fecal-oral route--i.e., by ingestion of virus shed in the stool of acutely infected individuals. The virus is transmitted from person to person or (in outbreaks) via contaminated food or water. Population groups at increased ri
Many public health and social issues relate to infection with the human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV)-the virus that causes the acquired immunodeficiency syndrome. One such issue is the care and education of infected children, both in schools and in day care facilities.
Estevez ME; Ballart IJ; Diez RA; Planes N; Scaglione C; Sen L
We studied the functions of peripheral blood monocytes and polymorphonuclear cells in 15 apparently healthy homosexual men, eight homosexual or bisexual subjects with unexplained generalized lymphadenopathies (pre-AIDS), four homosexual men with acquired immunodeficiency syndrome (AIDS), and 15 heterosexual men. In co
The acquired immune deficiency syndrome (AIDS) is characterized by infections with microorganisms against which phagocytes (especially monocytes/macrophages) play an important role. Therefore, various functions of blood monocytes and neutrophils were tested in 16 patients with AIDS. Neutrophil chemotactic responses to
Papasteriades C; Varla M; Economidou J; Marcacis K; Mitsouli C; Louisou K; Mandalaki T; Roumeliotou A; Papaevangelou G
Sixty unrelated Greek patients with haemophilia (46 with haemophilia A and 14 with haemophilia B) were typed for HLA-A, B and DR antigens. A highly significant increase in the frequency of HLA-DR5 was observed in both groups of patients (58.6% vs 30.0%, chi 2 = 10.47, pc less than 0.03, RR = 3.31 for haemophilia A and
Virology. 1986 Oct 15;154(1):67-75. Unique Identifier : AIDSLINE MED/86317723
Seigel LJ; Nash WG; Poiesz BJ; Moore JL; O'Brien SJ
The progression of HTLV-I proviral integration over a 3-year period of in vitro culture was examined in two human lymphoma lines, Hut 102 and MJ. Using specific HTLV-I molecular clones and a Southern analysis at different cell passages, Hut 102 increased from 2 to 19 integrated proviral integrations while MJ increased
Elevated neopterin levels are indicative of activation of the cellular immune system. Studies on excretion of neopterin in patients with AIDS and ARC, as well as in members of risk groups have demonstrated repeated or permanent stimulation of the immune system. This stimulation can be observed in all risk groups indep
Sera of 71 intravenous drug abusers imprisoned in Austria were tested for HTLV-III antibodies and the results correlated with the case histories and available clinical data. 12 sera, i.e. 17%, were found to be positive. Seronegative and seropositive drug addicts showed no notable
Z Gastroenterol. 1986 Jun;24(6):291-7. Unique Identifier : AIDSLINE MED/86318229
Purrmann J; Miller B; Strohmeyer G
Various kinds of gastrointestinal symptoms are seen in connection with AIDS. Furthermore, because of special sexual practices, other sexually transmitted diseases are found, especially in the oral cavity, the oesophagus and the anorectum. Whereas in most of the cases infections can be treated successfully under a stri
Z Gastroenterol. 1986 Jun;24(6):298-301. Unique Identifier : AIDSLINE MED/86318230
Sinn I; Brummer M; von Gaisberg U
A twenty six year old homosexual male with the diseases Hepatitis B, Lues, Gonorrhoea, ascending myelitis, lymphadenitis got additionally a chronic-inflammatory bowel disease, which first was discussed as Crohn s disease. Two attacks were successfully treated with Methylprednisolone. The patient died twelve month late
Two patients with AIDS developed paraparesis. Neuropathological post mortem examination in one revealed cytomegalovirus polyradiculopathy, and in the second, vacuolar myelopathy which occurred in association with brain lesions resembling Marchiafava-Bignami Syndrome.
Three commercial enzyme-linked immunosorbent assays (ELISA) for acquired immune deficiency syndrome (AIDS) virus antibodies were evaluated using serum that had been characterized by an ELISA and western blot procedure developed at the University of California at Davis (UCD). Each of the commercial tests was more speci
Ann Intern Med. 1986 Oct;105(4):519-27. Unique Identifier : AIDSLINE MED/86321435
Anderson KC; Gorgone BC; Marlink RG; Ferriani R; Essex ME; Benz PM; Groopman JE
Transmission of the human immunodeficiency virus (HIV) was studied in a group of patients with cancer who received transfusion of blood components harvested from a single, asymptomatic, seropositive donor. Of ten living recipients, nine had antibodies to the virus in fresh or cryopreserved sera at a median of 384 days
Ann Intern Med. 1986 Oct;105(4):536-8. Unique Identifier : AIDSLINE MED/86321437
Wood CC; Williams AE; McNamara JG; Annunziata JA; Feorino PM; Conway CO
In a 6-month study, antibody levels against the human immunodeficiency virus (HIV) were determined in intravenous gammaglobulin preparations and 45 serum samples from 20 patients on gammaglobulin therapy. All 10 lots of a reduced and alkylated preparation and 4 of 8 lots of a pH4/pepsin-treated preparation were seropo
Ann Intern Med. 1986 Oct;105(4):558-9. Unique Identifier : AIDSLINE MED/86321445
Maintenance dialysis can be continued in patients with end stage renal disease who have manifestations of human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) [now known as the human immunodeficiency virus], including the acquired immunodeficiency syndrome, or who are positive for antibo
Ann Intern Med. 1986 Oct;105(4):560-72. Unique Identifier : AIDSLINE MED/86321446
Greene WC; Leonard WJ; Depper JM; Nelson DL; Waldmann TA
The human receptor for interleukin-2 (T-cell growth factor) plays a critical role in the growth of T cells and is required for full expression of the normal immune response. Through hybridoma and recombinant DNA techniques, the interleukin-2 receptor protein has been biochemically characterized and purified; full-leng
Phosphonoformate and recombinant alpha-A interferon synergistically inhibited the replication of human T-cell lymphotropic virus type III in cultured peripheral blood lymphocytes. T-cell proliferative capability was maintained by this combination, and toxicity was minimal.
Leukemic cells in the peripheral blood of a patient with adult T cell leukemia (ATL), which expressed the Tac antigen/interleukin 2 (IL2) receptor, were investigated in vitro for autocrine growth by IL 2. The cells showed spontaneous proliferation in mitogen-free medium. The spontaneous proliferation of the cells was
Lancet. 1986 Aug 30;2(8505):483-6. Unique Identifier : AIDSLINE MED/86309762
Reesink HW; Lelie PN; Huisman JG; Schaasberg W; Gonsalves M; Aaij C; Winkel IN; van der Does JA; Hekker AC; Desmyter J; et al
Six commercial enzyme immunoassays (EIA) were evaluated in 6488 serum samples, with immunoblot analysis as the confirmatory test for antibodies against human immunodeficiency virus (HIV). The Abbott and Wellcome tests identified all 163 immunoblot-positive samples correctly, whereas the other tests did not detect 1-3
Berthier A; Chamaret S; Fauchet R; Fonlupt J; Genetet N; Gueguen M; Pommereuil M; Ruffault A; Montagnier L
In a study of the transmissibility of human immunodeficiency virus (HIV) in haemophilic and non-haemophilic children living together in a boarding school in France , half of the haemophilic children had seroconverted by the end of a 3-year study period. By contrast none of the non-h
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