Endogenous hypertriglyceridemia in a nonobese rat model: plasma lipoproteins and dietary sensitivity. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Endogenous hypertriglyceridemia in a nonobese rat model: plasma lipoproteins and dietary sensitivity.

Metabolism. 1986 May;35(5):436-40. Unique Identifier : AIDSLINE MED/86202740
Lovati MR; Franceschini G; Allievi L; Dall'Aglio E; Zavaroni I; Sirtori CR

Abstract: Sprague-Dawley male rats from the Ivanovas-Sieve colony (IVA-SIV) show higher plasma triglyceride levels compared to the standard Charles River (CR) rats. The triglyceride enrichment occurs primarily in the very-low-density lipoproteins (VLDL), otherwise of a normal % composition, suggesting that the number of particles is increased, rather than their triglyceride (TG) content. High-density lipoprotein (HDL) particles, corresponding to HDL1, appear to be increased in the IVA-SIV rats, as confirmed by rate-zonal ultracentrifugation. The apoprotein composition of isolated lipoproteins (apo B content and isoelectric focusing pattern), does not differ in the two strains. The IVA-SIV rats are remarkably more TG inducible, compared to the standard CR. This can be shown with fructose loading and with a cholesterol-cholic acid diet. The plasma TG increase, after Triton administration, indicative of the VLDL-TG production, is fourfold higher in the IVA-SIV, compared to the CR rats. These findings provide evidence for some similarities between the IVA-SIV rat and human endogenous hypertriglyceridemia, and suggest an increased TG biosynthesis in this model.
Keywords: Animal Body Weight Centrifugation, Zonal Cholesterol, Dietary/ADMINISTRATION & DOSAGE Cholic Acids/ADMINISTRATION & DOSAGE *Diet Dietary Carbohydrates/ADMINISTRATION & DOSAGE Disease Models, Animal Fructose/ADMINISTRATION & DOSAGE Hyperlipoproteinemia Type IV/BLOOD/*VETERINARY Isoelectric Focusing Lipids/BLOOD Lipoproteins/*BLOOD Male Polyethylene Glycols/ADMINISTRATION & DOSAGE Rats Rats, Inbred Strains/*BLOOD Rodent Diseases/BLOOD Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDanimalbodyweightcentrifugation,zonalcholesterol,dietary/administration&dosagecholicacids/administration&dosageKWDdietdietarycarbohydrates/administration&dosagediseasemodels,animalfructose/administration&dosagehyperlipoproteinemiatypeiv/blood/KWDveterinaryisoelectricfocusinglipids/bloodlipoproteins/KWDbloodmalepolyethyleneglycols/administration&dosageratsrats,inbredstrains/KWDbloodrodentdiseases/bloodsupport,non-uKWDsKWDgov'tjournalarticle
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M8680255

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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