Persistence of multiply antibiotic-resistant Campylobacter jejuni in a patient with the acquired immune deficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Persistence of multiply antibiotic-resistant Campylobacter jejuni in a patient with the acquired immune deficiency syndrome.

Am J Med. 1986 May;80(5):965-70. Unique Identifier : AIDSLINE MED/86212324
Dworkin B; Wormser GP; Abdoo RA; Cabello F; Aguero ME; Sivak SL

Abstract: Chronic diarrhea due to Campylobacter jejuni has been described in patients with hypogammaglobulinemia. A patient with the acquired immune deficiency syndrome (AIDS) and normal total serum immunoglobulins had persistent diarrhea and C. jejuni on stool culture for seven and a half months despite repeated antibiotic therapy. Antibiotic sensitivity studies revealed the C. jejuni to be multiply antibiotic-resistant. Evaluation of the mechanism of resistance showed the organism harbored a conjugative plasmid capable of transferring resistance to tetracycline, but not to other antibiotics. It is concluded that C. jejuni infection may rarely result in chronic diarrhea in patients with AIDS. The combination of an immune deficiency state including abnormal B cell function previously described in AIDS and multiple antibiotic resistance may have contributed to the persistence of the organism in this case.
Keywords: Acquired Immunodeficiency Syndrome/*MICROBIOLOGY Adult Campylobacter fetus/DRUG EFFECTS/*ISOLATION & PURIF Campylobacter Infections/MICROBIOLOGY Case Report Chronic Disease Diarrhea/MICROBIOLOGY Drug Resistance, Microbial Feces/MICROBIOLOGY Female Human Microbial Sensitivity Tests Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

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M8680228

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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