Lymphocyte subpopulation abnormalities in sickle cell anemia: a distinctive pattern from that of AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Lymphocyte subpopulation abnormalities in sickle cell anemia: a distinctive pattern from that of AIDS.

Am J Hematol. 1986 Jan;21(1):23-7. Unique Identifier : AIDSLINE MED/86212142
Ballester OF; Abdallah JM; Prasad AS

Abstract: In this study, we evaluated lymphocyte subpopulations in 23 adults with SCA. When compared to controls, SCA patients had higher lymphocyte counts with normal numbers of T101+ cells (T-lymphocytes) and T4+ cells. T8+ cells were significantly increased in SCA patients in comparison to controls (1684 +/- 243 vs 980 +/- 367, p less than .001). This increment was largely dependent on a T101-, T8+ cell population. The SCA patients as a group had significantly decreased T4/T8 ratio (p less than .0001). The SCA patients with history of blood transfusions had higher T4+ cells numbers and higher T4/T8 ratio, but no other significant differences from nontransfused patients were noted. Our results are different from those reported for nontransfused children with SCA who showed normal T4/T8 ratio. Thus, a distinct pattern of abnormalities is seen in the lymphocyte subpopulations of adult SCA patients, unrelated to their exposure to blood transfusions.
Keywords: Acquired Immunodeficiency Syndrome/*PATHOLOGY Adult Anemia, Sickle Cell/*PATHOLOGY/THERAPY Antibodies, Monoclonal/DIAGNOSTIC USE Blood Transfusion Comparative Study Female Human Leukocyte Count Lymphocytes/CLASSIFICATION/*PATHOLOGY Male Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDpathologyadultanemia,sicklecell/KWDpathology/therapyantibodies,monoclonal/diagnosticusebloodtransfusioncomparativestudyfemalehumanleukocytecountlymphocytes/classification/KWDpathologymalesupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,non-pKWDhKWDsKWDsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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M8680221

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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