Phoenix, Ariz. : Oryx Press, 1985 60 p (Oryx science bibliographies ; v. 1) Unique Identifier : AIDSLINE CAT/8607650
Tyckoson DA
Selected, evaluated, and current references on AIDS. Intended for undergraduate level; contains only English-language materials. Topical arrangement with introductory information on each topic. Entries give bibliographic information, annotation. Bold face citations indicate the most important references. Author ind
Health Educ J. 1985;44(4):169-71. Unique Identifier : AIDSLINE AHA/86195231
Kurtz Z
The current state of knowledge about acquired immune deficiency syndrome (AIDS) is outlined, and current health education advice summarised. Arguments for an intensive, integrated health education campaign to allay fear and promote preventive action are presented.
Health Educ J. 1985;44(4):172-3. Unique Identifier : AIDSLINE AHA/86195232
Griffiths C; Cruse E; Harries J; Williams T; Littlepage BN
An education programme on AIDS has been established in West Glamorgan. It was designed to provide an information network amongst health authority staff which would reach as wide an audience as possible. The programme has been organised on a direct contact approach because of the limitations of other methods of dissemi
Although the exact impact of AIDS on the health care delivery system is unknown, the evidence to date supports some grim predictions. Hundreds of thousands of victims can be expected, with costs of care reaching the multi-billions. Providers need to prepare now for what is apt to be a serious financial, organizational
Zanetti AR; Ferroni P; Colombo M; Cargnel A; Mari D; Zehender G; Rumi MG; Gringeri A; Ammassari M; Mannucci PM
We have studied anti-LAV/HTLV-III antibody prevalence in individuals at high risk for infection, such as intravenous drug addicts, hemophiliacs and homosexual men. Among intravenous drug addicts, LAV/HTLV-III infection was first recognized in 1981 and positive serum reactions for anti-LAV/HTLV-III antibody rose in suc
The delta agent is a unique virus-like human pathogen that superinfects individuals with hepatitis B virus. It is a defective particle that requires for its replication and expression obligatory helper functions provided by the hepatitis B virus. It is transmitted through blood products and body fluids via both parent
Some legal scholars propose that the right of privacy articulated by the United States Supreme Court should be extended to protect homosexual activity. In light of the advent of AIDS, should that extension include constitutional protection for homosexual men who frequent gay bathhouses
Patients with various conditions associated with immunologic deficiency (cancer, radiotherapy, surgery, burns, aging, prodromal Acquired Immunodeficiency Syndrome, were treated with inosiplex (INPX) at a dose of 3-4 g/day for periods of time ranging from 1 week to several months. Patients were evaluated clinically, an
Sprague-Dawley male rats from the Ivanovas-Sieve colony (IVA-SIV) show higher plasma triglyceride levels compared to the standard Charles River (CR) rats. The triglyceride enrichment occurs primarily in the very-low-density lipoproteins (VLDL), otherwise of a normal % composition, suggesting that the number of particl
Soulen MC; Fishman EK; Scatarige JC; Hutchins D; Zerhouni EA
We describe a patient who had cryptosporidiosis and cytomegalovirus infection of the gastric antrum that was initially detected on computed tomography (CT) scans. CT may be useful in the evaluation of immunocompromised patients with diarrheal illness, as well as in the assessment o
Bull s-eye retinopathy has multiple associations. We report a case of bull s-eye retinopathy presumed to be secondary to clofazimine (Lamprene) treatment of a 30-year-old patient with acquired immunodeficiency syndrome (AIDS). Pretreatment baseline eye exam of this patient was normal except for bilateral cotton-wool s
Epidemiologic inferences about the epidemic of acquired immunodeficiency syndrome (AIDS) are developed from three different sources: case-control studies, cohort studies, and national data on prevalence and incidence. Together these data imply that reducing the number of sexual partners may in itself provide little pr
Am J Gastroenterol. 1986 Jun;81(6):465-70. Unique Identifier : AIDSLINE MED/86212107
Garone MA; Winston BJ; Lewis JH
A patient with acquired immune deficiency syndrome who developed symptoms of partial gastric outlet obstruction during the course of a severe diarrheal illness due to cryptosporidiosis is presented. Endoscopic evaluation of the stomach revealed an inflamed pyloric ring and channel with clinical evidence suggestive of
Am J Epidemiol. 1986 Jun;123(6):1013-25. Unique Identifier : AIDSLINE MED/86212120
Since the epidemic of the acquired immunodeficiency syndrome (AIDS) was first recognized in 1981, New York City has had more cases and a higher incidence than any other city in the world. As of July 31, 1985, 4,133 cases had been reported to the New York City Department of Health, a cumulative incidence of 59 cases pe
Am J Med. 1986 May;80(5):954-8. Unique Identifier : AIDSLINE MED/86212322
Mitsuyasu RT; Colman MF; Sun NC
Kaposi s sarcoma and Hodgkin s disease have each been associated with abnormalities in T lymphocyte function and occur with increased frequency in the immunosuppressed host. Although the association of Kaposi s sarcoma with lymphoreticular disorders has long been recognized, only sporadic cases of Hodgkin s disease ha
Chronic diarrhea due to Campylobacter jejuni has been described in patients with hypogammaglobulinemia. A patient with the acquired immune deficiency syndrome (AIDS) and normal total serum immunoglobulins had persistent diarrhea and C. jejuni on stool culture for seven and a half months despite repeated antibiotic the
Nine open lung biopsies and nine transbronchial biopsies from 10 patients with pulmonary Kaposi s sarcoma were reviewed to define the pattern of involvement in the lung by Kaposi s sarcoma and to determine the usefulness of transbronchial biopsy in making the diagnosis. There were nine patients with acquired immune de
Am J Hematol. 1986 Jan;21(1):23-7. Unique Identifier : AIDSLINE MED/86212142
Ballester OF; Abdallah JM; Prasad AS
In this study, we evaluated lymphocyte subpopulations in 23 adults with SCA. When compared to controls, SCA patients had higher lymphocyte counts with normal numbers of T101+ cells (T-lymphocytes) and T4+ cells. T8+ cells were significantly increased in SCA patients in comparison to controls (1684 +/- 243 vs 980 +/- 3
Specimens from premortem pulmonary cytology, transbronchial biopsy, and autopsy were studied in 11 patients with acquired immunodeficiency syndrome who developed pulmonary cryptococcal disease. Nine of 11 patients had culture-proved cryptococcal meningitis. Extremely low T-cell helper/suppressor ratios (mean, 0.12) we
A brief description of AIDS and suggested guidelines for providing nursing care to the parturient AIDS victim are provided. The current literature in defining the syndrome, its course, and its statistics is surveyed. Infection control precautions that need to be adapted when caring for the mother and infant who are af
Proc Natl Acad Sci U S A. 1986 May;83(10):3051-5. Unique Identifier : AIDSLINE MED/86205837
Lui KJ; Lawrence DN; Morgan WM; Peterman TA; Haverkos HW; Bregman DJ
The incubation period, representing the interval between the date of exposure and the date of diagnosis, can be firmly ascertained in transfusion-associated cases of acquired immunodeficiency syndrome (AIDS). However, because the observation period of all transfusion-infected persons may be short compared with the ave
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2566-70. Unique Identifier : AIDSLINE MED/86205992
Williams DA; Orkin SH; Mulligan RC
Deficiency of the enzyme adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4; ADA) leads to severe combined immunodeficiency, a disorder that potentially could be corrected by gene transfer into hematopoietic cells. We have constructed retroviruses containing human ADA cDNA and a dominant selectable marker, a mu
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2682-3. Unique Identifier : AIDSLINE MED/86206016
Kuno S; Ueno R; Hayaishi O
To explain a possible pathogenesis of acquired immune deficiency syndrome (AIDS) in homosexual males, we propose the following hypothesis. Prostaglandin E2 in human semen given via anus during anal intercourse may cause an immune dysregulation in the male semen recipients; this immunosuppressive effect of prostaglandi
An increase in circulating eosinophils was observed in patients with AIDS or ARC who were substituted for a period of 14 days with exogenous recombinant IL-2 in the context of a Phase I/II study. IL-2 exerts a broad range of biological properties and enhances the produ
The effects of administration for four days of co-trimoxazole (2 X 500 mg tablets daily) and erythromycin stearate (3 X 500 mg tablets daily) on persistently abnormal polymorphonuclear leucocyte (PMNL) migration in six individuals with a history of chronic or recurrent bacterial infections were studied. The effects of
Tsai CC; Giddens WE Jr; Ochs HD; Morton WR; Knitter GH; Blakley GA; Benveniste RE
A simian acquired immunodeficiency syndrome (SAIDS) associated with retroperitoneal fibromatosis (RF) has been observed in several species of macaque at the Washington Regional Primate Research Center. Clinical signs were recurrent diarrhea, weight loss, mesenteric lymphadenopathy, and opportunistic infections. Most a
Interleukin 1 (IL-1) is a monocyte-derived mediator that participates in the regulation of various T-lymphocyte activities, among them IL-2 production. Since IL-2 deficiency is a central feature in the immunological profile of the acquired immunodeficiency syndrome (AI
de Paoli P; Reitano M; Martelli P; Battistin S; Villalta D; Carbone A; Tirelli U; Santini G
We undertake a study of Italian intravenous drug abusers and male homosexuals with the prolonged generalized lymphadenopathy syndrome (PGL). 75% of the subjects had the HLA-DR 5 antigen (relative risk 3.25). Only one patient was DR 2 positive. 14/20 subjects had anti-HTLV III antibodies and immunological malities were
Cell. 1986 May 9;45(3):375-85. Unique Identifier : AIDSLINE GENBANK/M12349
Sonigo P; Barker C; Hunter E; Wain-Hobson S
The genetic structure of Mason- Pfizer monkey virus (MPMV), a D-type retrovirus, has been determined. In addition to the viral gag, pol, and env genes is an ORF overlapping both gag and pol and that encodes the viral protease. Surprisingly, the MPMV env protein is highly ho
Seven patients with acquired immunodeficiency syndrome (AIDS) and Pneumocystis carinii pneumonia were studied to define the pathophysiology of their respiratory failure. The patients had fever, cough, dyspnea, hypoxemia, and diffuse infiltrates on chest x-ray. Biopsies revealed a spectrum of alveolar filling, intersti
Male Sprague-Dawley IVA-SIV rats were compared to male Sprague-Dawley Charles River rats of the same age, body weight, and daily food intake. The IVA-SIV rats demonstrated hypertriglyceridemia (182 +/- 9.4 v 131 +/- 9.4 mg/dL, P less than 0.001), associated with increased fasting plasma glucose (115 +/- 3 v 84 +/- 2 m
Annu Rev Med. 1986;37:173-8. Unique Identifier : AIDSLINE MED/86213843
Dinarello CA; Mier JW
Interleukins are polypeptides that act on leukocytes and other tissue targets. Interleukin-1, produced by macrophages and other cells, activates lymphocytes and also induces several components of the host s acute-phase response to infection and injury. Interleukin-2, produced by T lymphocytes, is a growth factor for h
Br Med J (Clin Res Ed). 1986 Mar 29;292(6524):854-7. Unique Identifier : AIDSLINE MED/86188580
Moestrup T; Hansson BG; Widell A; Nordenfelt E; Hagerstrand I
Long term follow up of 16 homosexual men and 78 intravenous drug abusers who were chronic carriers of hepatitis B surface antigen (HBsAg) showed fundamental differences between the two groups. Viral replication, expressed by the presence of hepatitis B e antigen, lasted for four years or more in 10 out of 14 (71%) of
J Immunol. 1986 May 15;136(10):3773-8. Unique Identifier : AIDSLINE MED/86197738
Stewart SJ; Fujimoto J; Levy R
An analysis of the cellular distribution, biosynthesis, and structure of the human T lymphocyte antigen Leu-3(T4) was performed. By using a sensitive ELISA as well as FACS analysis, relative quantities of the Leu-3(T4) antigen from whole cell lysates and from cell surfaces of six cell lines were determined. The T-T hy
To examine the role of antihemophilic factor (factor VIII) preparations in the pathogenesis of subclinical immunodeficiency in hemophilia, we tested the in vitro effects of these products on immune function. Both lyophilized antihemophilic factor (LAHF) and cryoprecipitates inhibited lymphocyte proliferation in a dose
Most retroviruses are immunosuppressive in vitro and in vivo. They are able to enhance virus-induced tumor development and/or to induce acquired immune deficiency syndromes (AIDS) which are characterized by malignant tumors and opportunistic infections. Experimental evidence for the immunosuppressive properties of sev
Tausk FA; McCutchan JA; Schreiber RD; Spechko P; Gigli I
The expression of C3b receptors (CR1) on erythrocytes of gay men at various levels of risk for AIDS was studied. Fourty-nine heterosexual male controls had a mean (X) +/- standard deviation of 516 +/- 136 CR1 per erythrocyte (CR1-3); 17 asymptomatic gay men had X = 423 +/- 156, 16 gay men with one AIDS-related complex
Can Med Assoc J. 1986 May 1;134(9):1013-7. Unique Identifier : AIDSLINE MED/86189305
Boyko WJ; Schechter MT; MacLeod A; Douglas B; Maynard M; Sharp R; Wiggs B
Abnormalities of lymphocyte subsets, especially low absolute number of helper T cells, are characteristically present in acquired immune deficiency syndrome (AIDS). Similar abnormalities can be found in patients with persistent generalized lymphadenopathy (PGL) or AIDS-related complex (ARC) and, to a lesser degree, in
Patients with acquired immunodeficiency disease syndrome (AIDS) show a complex spectrum of immunological abnormalities. We have examined B-lymphocyte function in 58 patients with AIDS and Kaposi s sarcoma. The major finding has been that the specific antibody response to sheep red blood cell antigen in vitro is severe
Kiprov DD; Lippert R; Miller RG; Sandstrom E; Jones FR; Cohen RJ; Abrams D; Busch DF
Circulating immune complexes, autoantibodies, and suppressor factors to normal lymphoproliferation may play an important role in the induction and maintenance of the cellular immunodeficiency characteristic for the acquired immunodeficiency syndrome (AIDS) and its related conditions. In order to explore the possibilit
A male patient with a 14-year history of UC (ulcerative colitis) had a helper-suppressor ratio (H/S) of 0.25 during a suspected exacerbation of chronic colitis. Prednisone and sulfasalazine were administered. Despite a transient clinical response he developed AIDS (acquired immune deficiency syndrome) and KS (Kaposi s
Annu Rev Med. 1986;37:165-72. Unique Identifier : AIDSLINE MED/86213842
Young M; Geha RS
The immune response is under the regulation of T-cell populations that are characterized by defined cell surface markers. The differentiation and functional heterogeneity of these T-cell subsets are discussed in normal and disease states.
Distinctive patterns of skin disease other than Kaposi s sarcoma have been in patients with AIDS, in others with persistent generalized lymphadenopathy (PGL) and in a group at high risk of developing AIDS. We found a chronic acneiform folliculitis on the face, back, chest and buttocks, extensive cutaneous fungal infec
A 70-year-old male and a 46-year-old female, both living in Japan , were seen because of multiple erythematous papules and plaques on the trunk and extremities. The peripheral white blood cell counts were increased to 30,000-80,000/mm3. The majority of white cells had characteristic
Bromwich PD; Walker AP; Gregson SH; Ross CF; Eglin RP; Macey JE
This study suggests that, at the present time, AID is not likely to be a significant risk factor in the transmission of AIDS in Britain, particularly in centres which are already practising careful screening of semen donors. New facilities which are becoming available for HTLV-III screening should help to provide reas
The chromosomal breakage syndromes--ataxia-telangiectasia, Fanconi s anemia, and Bloom s syndrome--are associated with growth failure, neurologic abnormalities, immunodeficiency, and an increased incidence of malignancy. The relationship between these features is unknown. We recently evaluated a 21-year-old female wit
Cancer. 1986 Jun 1;57(11):2190-2. Unique Identifier : AIDSLINE MED/86189419
Burkes RL; Sherrod AE; Stewart ML; Gill PS; Aguilar S; Taylor CR; Krailo MD; Levine AM
In order to investigate the nature of the immune disorders associated with the acquired immune deficiency syndrome (AIDS) and the AIDS-related condition of persistent, generalized lymphadenopathy (PGL), serum beta-2 microglobulin (beta 2-M) levels were determined in patients with AIDS and PGL and in asymptomatic homos
Cancer Lett. 1986 Mar;30(3):299-310. Unique Identifier : AIDSLINE MED/86189479
Koyanagi Y; Harada S; Yamamoto N
A cell culture system was developed for the continuous and efficient production of acquired immune deficiency syndrome (AIDS) retrovirus. After infection of a human T-cell line Molt-4 with HTLV-III and LAV the cells grow permanently and produce large amounts of virus continuously. The yields of production of virus wer
Urinary excretion of modified nucleosides and beta-aminoisobutyric acid, subsequently referred to as markers, was determined in populations of patients with acquired immunodeficiency syndrome (AIDS) or at risk for development of AIDS. Our results show that asymptomatic adult male homosexuals excreted elevated amounts
We tested 146 clinical-laboratory quality-assurance sera for antibodies to human T-lymphotropic virus III (HTLV-III). Of 127 human-based samples, 39 (31%) were positive by an immunoenzymometric assay (IEMA). Samples of human origin that gave IEMA reactivity included four of 10 ethylene glycol-based (liquid) samples, t
The X-linked lymphoproliferative syndrome (XLPS) is an immunodeficiency characterized by severe primary infection with the Epstein Barr (EB) virus, which is often fatal. This has been attributed to failure to generate T lymphocytes which are specifically cytotoxic for EB virus-infected B lymphocytes, and which develop
Biagiotti R; Giudizi MG; Almerigogna F; Mazzetti M; Alessi A; Del Prete GF; Rafanelli D; Fiorilli M; Morfini M; Romagnani S
The pokeweed mitogen (PWM)-induced immunoglobulin (Ig) production by cultures of peripheral blood mononuclear cells (PBMC) was reduced in healthy haemophiliacs treated with commercial factor VIII (or IX) concentrate, whereas the spontaneous IgG synthesis in vitro was enhanced. PWM-induced Ig production was lower in th
Greyson-Fleg RT; Jones B; Fishman EK; Hamilton SR; Siegelman SS
The computed tomography findings in two cases of gastrointestinal superinfection by opportunistic organisms in acquired immune deficiency syndrome are presented. Findings included thickening of the mucosal folds and the bowel wall in the small intestine and colon associated with cytome
FEBS Lett. 1986 Apr 21;199(2):145-50. Unique Identifier : AIDSLINE MED/86192803
Yasunaga T; Sagata N; Ikawa Y
The protease gene structure and the env gene variability have been precisely compared between the AIDS virus and members of the HTLV/BLV family. The conserved amino acid sequence (LVDT) which is repeated in the proteases of the HTLV/BLV family is not repeated in AIDS virus. Comparative analysis of the env gene sequenc
A case of recurrent typhoid fever in a homosexual man with antibodies to human T-cell lymphotropic virus-III (HTLV-III) and impaired cell mediated immunity is reported: we believe the first report of Salmonella typhi infection in association with HTLV-III disease.
Ichimaru M; Kinoshita K; Kamihira S; Ikeda S; Yamada Y; Suzuyama J; Momita S; Amagasaki T
Sixteen families, each with two or more cases of adult T-cell leukemia or lymphoma were found in the Nagasaki district. Eight of the families had a parent with lymphoma. In the other eight families siblings were involved. Four families with sibling cases are presented in detail. Antibody titres to adult T-cell leukemi
According to the Vital Statistics Japan Series in 1950-1981, the age-adjusted death rate for malignant lymphomas (ICDs, 200-202) in Japan has increased in recent years. A geographical clustering of malignant lymphomas in the Kyushu districts was observed both in the period 1969-1971
Yamaguchi K; Yoshioka R; Kiyokawa T; Seiki M; Yoshida M; Takatsuki K
The clinical and pathological features of T-cell type malignant lymphoma related to human T-cell leukemia virus (HTLV) were investigated in eight patients presenting lymphadenopathy. Biopsy of lymph nodes showed an histology of diffuse non-Hodgkin s lymphoma . All patients were posi
Kikuchi M; Mitsui T; Takeshita M; Okamura H; Naitoh H; Eimoto T
Virus associated adult T-cell leukemia/lymphoma (ATLL), which includes both adult T-cell leukemia (ATL) and its non-leukemic counterpart (NLATL) was studied clinically, histologically, and immunologically. The disease usually occurred in the sixth decade in both sexes equally. The patients had a rapid clinical course
Int J Cancer. 1986 May 15;37(5):775-9. Unique Identifier : AIDSLINE MED/86194823
Akagi T; Takata H; Ohtsuki Y; Takahashi K; Oka T; Yano S; Miyoshi I
Co-cultivation of spleen cells of Syrian golden hamsters with lethally irradiated MT-2 cells harboring human T-cell leukemia virus type I (HTLV-I) resulted in the establishment of lymphoid cell lines, HCT-1 and HCT-2, which exhibited the normal karyotype of golden hamsters. Cells of both the HCT-1 and HCT-2 lines lack
In a 30-year-old German women who appeared to be in good general health, numerous Kaposi sarcomas of the AIDS type appeared on her face and trunk within a few days. Her arms, legs and oral mucosa were also affected. The patient has been a prostitute for more than 10 years and an i.v. drug addict for 5 years. Her face
We present a case of AIDS with Kaposisarcoma in the oropharynx. In this case chemotherapy and radiotherapy were used with good response. Because of the clinical features of the disease otolaryngologists will be involved more and more in the management of AIDS disease. The diagnosis, therapy, and prognosis of the follo
The core of the fibronectin cell-attachment site has been shown to be the tetrapeptide sequence Arg-Gly-Asp-Ser (RGDS). This peptide as well as its inverted analogue Ser-Asp-Gly-Arg (SDGR) efficiently inhibit fibronectin-mediated cell attachment in vivo and in vitro. Homology searches in protein data banks revealed th
Tanaka N; Okabe T; Tanaka N; Take Y; Inouye Y; Nakamura S; Nakashima H; Yamamoto N
In the course of screening for inhibitors of reverse transcriptase, we have isolated an inhibitor from a strain of Nocardia and identified it as sakyomicin A. The antibiotic blocks avian myeloblastosis virus reverse transcriptase reaction: IC50 was ca. 30 micrograms/ml by the method employed. The drug affects prolifer
Monoclonal antibody NCC-pX-1G (IgG1, kappa) was obtained by the hybridoma technique by immunization of mice with the C-terminal 54 amino acids of the pX protein, made from the 3 -terminal portion of the pX gene conjugated with bovine growth hormone gene transfected in E. coli. NCC-pX-1G recognized 41 kilodalton pX pro
Sera from patients with adult T-cell leukemia and asymptomatic carriers of human T-cell lymphotropic virus type I (HTLV-I) from widely separated areas of the world reacted strongly in a standardized quantitative enzyme-linked immunosorbent assay procedure with HTLV-I viral antigen prepared from a strain isolated in th
Significantly higher proportions of patients with acquired immune deficiency syndrome (AIDS) or lymphadenopathy syndrome (LAS) were positive for antibodies to cytomegalovirus ( CMV ) and herpes simplex virus (HSV) compared with
The Abbott enzyme immunoassay ( Abbott Laboratories , North Chicago, Ill.) for human T-cell lymphotropic virus type III (HTLV-III) antibody was evaluated to determine the effect of using heat-inactivated (56 degrees C for 30 min) serum as the sample. Each of 58 nonreactive serum sam
We developed cloned populations from the commonly available, well-characterized cell line HUT-78. These cloned cells grow permanently after infection with isolates of human T-lymphotropic virus type III, also called lymphadenopathy virus (HTLV-III/LAV), from patients with acquired immune deficiency syndrome and relate
Yarchoan R; Guo HG; Reitz M Jr; Maluish A; Mitsuya H; Broder S
HTLV-I is a transforming human retrovirus that is an etiologic agent of adult T cell leukemia/lymphoma. To investigate the effects of this virus on T cell functions, two OKT3+, OKT4+, OKT8- cytotoxic clones (8.7 and 8.8) specific for allogeneic cells bearing DPw2, a class II histocompatibility antigen, were studied be
Normal blood-derived monocyte/macrophages were found to be susceptible to infection in vitro by human T lymphotropic virus type III (HTLV-III), the etiologic agent of the acquired immunodeficiency syndrome. In addition, HTLV-III was recovered from monocyte/macrophages of patients infected with this virus. The above fi
Acquired immunodeficiency syndrome is associated with a viral (HTLV-III/LAV)-mediated progressive depletion of a helper/inducer T4+ T cell subset, whereas acute T cell leukemia is associated with a viral (HTLV-I)-mediated growth of the same T cell subset. Because large granular lymphocytes (LGL) with natural killer (N
J Immunol. 1986 Jun 1;136(11):4049-53. Unique Identifier : AIDSLINE MED/86197777
Folks T; Kelly J; Benn S; Kinter A; Justement J; Gold J; Redfield R; Sell KW; Fauci AS
Normal human peripheral blood lymphocytes were tested for their susceptibility to infection with retroviruses isolated from patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. Of 10 normal individuals tested, lymphocytes from all subjects became infected and produced virus as detected
Rustin MH; Ridley CM; Smith MD; Kelsey MC; Parker N
An illness characterised by fever, arthralgia, myalgia, a macular erythematous rash, a sore throat and the appearance of atypical lymphocytes in the blood film is described in a 27-year-old homosexual man. There was serological evidence that this illness was due to the human T-cell lymphotropic virus Type III.
Human T-cell leukemia virus type I (HTLV I) propagated in human diploid fibroblast IMR90 was transmitted to human promyelocytic leukemia HL60 cells by coculture. Of 14 provirus-positive HL60 clones, five harbored only defective proviruses, five had defective proviruses in addition to full-sized HTLV I, and four had fu
Caprine arthritis encephalitis virus (CAEV) is an exogenous, nononcogenic retrovirus which causes neurological disease and crippling arthritis in goats. A complete CAEV genome was cloned from unintegrated viral DNA in two fragments of 9.4 and 0.4 kilobases in length, respectively. The biological activity of these clon
Antibody prevalences for human T-cell lymphotropic virus (HTLV) types I, II, and III were determined for 56 intravenous drug abusers from Queens, NY. While control serum samples lacked antibodies to all HTLV subgroups, seropositivity among drug users was 41% for HTLV-III, 18% for HTLV-II, and 9% for HTLV-I. Infection
Manuel born in June 1984 is presented for the first time at the age of 6 months with the following symptoms: Otitis purulenta, enlargement of lymph-nodes, swelling of liver and spleen, enteritis, failure to thrive and candida albicansdermatitis. Immunoglobulins and the total serumprotein are elevated. At the age of 9
Kurth R; Schmidt I; Werner A; von Wangenheim G; Lower J; Brede HD
Samples of 96 polyvalent and virus-specific immunoglobulin batches commercially available in West- Germany were tested by enzyme-linked immunoassay and immunoblot for the presence of anti-HTLV-III antibodies. 37% of the polyvalent and 87% of the virus-specific batches were positive
Lemarie E; Musset M; Charbonnier C; Renoux M; Renoux G
Imuthiol is a nontoxic agent recruting and regulating T cells. Phase III studies in chronic bronchitis and bronchiectasis showed that immune functions were restored to normal, or near normal values. Cure was obtained in rheumatoid arthritis, tuberculosis and chronic infections in the elderly. Imuthiol is an effective
N Engl J Med. 1986 May 22;314(21):1354-9. Unique Identifier : AIDSLINE MED/86203480
Mascola L; Guinan ME
The practice of artificial insemination by donor semen is increasing in the United States . Many sexually transmitted organisms are found in semen, but screening procedures for the detection of these agents in donor semen have not been standardized. Sexually transmitted organisms have b
Of a total of 3,366 cases of malignant lymphoma in China reviewed histopathologically, T-cell lymphomas accounted for an average of 26.1% among all non-Hodgkin s lymphomas. However, the proportion of lymphomas of T-cell lineage varied in different parts of China, with the highest pr
Pathol Res Pract. 1986 Mar;181(1):85-92. Unique Identifier : AIDSLINE MED/86205560
Delisle MB; Bouissou H; Saidi A
Over the last few decades, a new pathology has appeared, directly related to the modified immune status of the hosts. It presents several distinctive points. The central nervous system is particularly affected. The opportunistic pathogenic agents do not usually injure the brain parenchyma and are not known for their a
Acquired immune deficiency syndrome (AIDS)-associated virus is thought to be transmitted effectively through semen during sexual activities from male to male or from male to female. Prostaglandin (PG) E2 is one of the immunosuppressive compounds present in high concentrations in human semen. We, therefore, investigate
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2672-6. Unique Identifier : AIDSLINE MED/86206014
Matsushita S; Robert-Guroff M; Trepel J; Cossman J; Mitsuya H; Broder S
We report the production and characterization of a human monoclonal antibody reactive against the major envelope glycoprotein of human T-cell leukemia virus type I (HTLV-I), a virus linked to the etiology of adult T-cell leukemia. We exposed lymph-node cells derived from a patient with adult T-cell leukemia to the Eps
Giudizi MG; Biagiotti R; Almerigogna F; Mazzetti M; Alessi A; Massai G; Longo G; Scano G; Morfini M; Romagnani S
Various immunological parameters exploring both T- and B-cell functions were determined in a group of 74 symptom-free Italian haemophiliacs treated with commercial concentrate imported from the USA and were correlated with the presence in their serum of antibody to HTLV-III. There was a strong correlation between HTLV
The NBT reduction of granulocytes was determined in 11 patients with HTLV-III infection. The reaction was measured in granulocytes both in resting state and after stimulation with Escherichia coli, as well as with and without addition of plasma. In 5 patients with AIDS, the NBT reduction was significantly decreased in
Science. 1986 May 16;232(4752):877-80. Unique Identifier : AIDSLINE MED/86208125
Greene WC; Leonard WJ; Wano Y; Svetlik PB; Peffer NJ; Sodroski JG; Rosen CA; Goh WC; Haseltine WA
The human T-lymphotropic viruses types I and II (HTLV-I and -II) have been etiologically linked with certain T-cell leukemias and lymphomas that characteristically display membrane receptors for interleukin-2. The relation of these viruses to this growth factor receptor has remained unexplained. It is demonstrated her
Science. 1986 May 23;232(4753):998-1001. Unique Identifier : AIDSLINE MED/86208145
Levy JA; Cheng-Mayer C; Dina D; Luciw PA
A molecular clone of the AIDS-associated retrovirus (ARV-2) was transfected into human T lymphocyte and monocyte cell lines as well as mouse, mink, monkey, and human fibroblast lines. A replicating virus with cytopathic and biologic properties of ARV-2 was recovered from all the cell lines. The animal and human fibrob
The formation of multinucleated giant cells with progression to cell death is a characteristic manifestation of the cytopathology induced by the AIDS retrovirus in infected T lymphoid cells. The mechanism of giant cell formation was studied in the CD4 (T4/Leu 3) positive T cell lines JM (Jurkat) and VB and in variants
Science. 1986 May 30;232(4754):1135-7. Unique Identifier : AIDSLINE MED/86208155
Sarin PS; Sun DK; Thornton AH; Naylor PH; Goldstein AL
An antiserum prepared against thymosin alpha 1, a hormone secreted by the thymus gland, effectively neutralized the AIDS-associated virus [HTLV-III/LAV (clone BH-10)] and blocked its replication in H9 cells. Reverse transcriptase activity and expression of the HTLV-III/LAV antigens p15 and p24 were inhibited by purifi
Ragni MV; Lewis JH; Bracken M; Toth R; Stokes J; Steffensen DO
Antibody to the acquired immunodeficiency syndrome (AIDS) retrovirus was evaluated by an lymphadenopathy-associated (LAV) enzyme immunosorbent assay (EIA) and compared with the standard human T-cell lymphotropic virus, Type III (HTLV-III) screening test in two groups of people. The first group consisted of those at lo
The ultrastructure of Kaposi s sarcoma (KS) of the oral mucosa in patients with acquired immune deficiency syndrome (AIDS) was examined electron microscopically. The tumour consisted of pleomorphic vascular endothelial structures and spindle cell formations. The KS cells contained characteristically numerous multivesi
The computed tomographic (CT) scans of 10 patients with acquired immunodeficiency syndrome who had central nervous system (CNS) involvement by cytomegalovirus ( CMV ) were retrospectively reviewed and correlated with clinical d
A test for the detection of antibodies to HTLV-III is available and will be widely used to screen donated blood to prevent transfusion-associated acquired immunodeficiency syndrome (AIDS). Based upon the sensitivity and specificity, the authors calculated the expected predictive values for different groups of asymptom
Ann Intern Med. 1986 Jun;104(6):824-5. Unique Identifier : AIDSLINE MED/86213439
Previous recommendations on preventing the transmission of the human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) in the workplace have emphasized health care settings. The current recommendations complement those previously discussed by listing specific guidelines to be followed by he
Annu Rev Med. 1986;37:271-81. Unique Identifier : AIDSLINE MED/86213853
Bodey GP; Fainstein V
Immunocompromised patients are susceptible to a variety of serious gastrointestinal infections. Among the most common or most severe are Mycobacterium avium-intracellulare, herpes simplex, candidiasis, cryptosporidiosis, and Salmonellosis. Some of these infections are difficult or impossible to treat successfully. The
Gan To Kagaku Ryoho. 1986 May;13(5):1791-7. Unique Identifier : AIDSLINE MED/86214091
Aoki T; Taguchi Y; Kaneko Y
It has been recently established that AIDS is a virus infectious disease. HTLV-I essentially makes T4 lymphocytes malignant and induces their abnormal proliferation. However, on the way, when HTLV-I induces a decrease in the function of T4 lymphocytes, the symptoms of ARC or AIDS take place on occasion. HTLV-III/LAV p
We describe a 78-year-old man with a diffuse large-cell lymphoma that was limited to the liver and was associated with micronodular cirrhosis and Kaposi s sarcoma that involved abdominal lymph nodes and gastric mucosa. The serum of the patient reacted positively to a test for human T-cell lymphotropic virus type III a
Aurintricarboxylic acid, an anionic triphenylmethane dye, and Evans Blue, an anionic compound structurally related to suramin, are, like suramin itself, inhibitors of human T-cell lymphotropic virus type III (HTLV-III)/-lymphadenopathy-associated virus (LAV) in vitro. These compounds may be targeted, at least in part,
Lancet. 1986 May 24;1(8491):1179-82. Unique Identifier : AIDSLINE MED/86202356
Weber JN; Wadsworth J; Rogers LA; Moshtael O; Scott K; McManus T; Berrie E; Jeffries DJ; Harris JR; Pinching AJ
170 symptom-free homosexual men were recruited in London in 1982-83 and 133 were evaluable in 1983-85. Of the 33 who were seropositive to HTLV-III/LAV at entry, 4 (12%) progressed to AIDS, 16 (48%) progressed to persistent generalised lymphadenopathy (PGL), and 13 (40%) remained symptom-free. A further 15 men seroconv
Peterman A; Jerdan M; Staal S; Bender B; Striecher H; Schupbach J; Resnick L
Human T-cell lymphotropic virus type I (HTLV-I) is a human retrovirus that can transform T-helper lymphocytes and is etiologically associated with adult T-cell lymphoma/leukemia. Mycosis fungoides represents a primary cutaneous lymphoma of helper T-cell origin, while chronic lymphocytic leukemia is generally considere
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