Augmentation of mitogen-induced proliferative responses by in vitro indomethacin in patients with acquired immune deficiency syndrome and AIDS-related complex.

Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

Augmentation of mitogen-induced proliferative responses by in vitro indomethacin in patients with acquired immune deficiency syndrome and AIDS-related complex.

Int J Immunopharmacol. 1985;7(6):917-21. Unique Identifier : AIDSLINE MED/86084672
Reddy MM; Manvar D; Ahuja KK; Moriarty ML; Grieco MH

Abstract: The effect of indomethacin on mitogen-induced lymphocyte proliferative responses was studied in six normal heterosexual subjects and nine patients with the acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC). Indomethacin enhanced only Con A-induced lymphocyte responses in six heterosexual men. In contrast, study of the cells from AIDS and ARC revealed that indomethacin enhanced PHA-induced lymphocyte proliferative responses from 52,600 counts/min to 70,900 counts/min (P less than 0.005) and 81,400 counts/min (P less than 0.001) at 0.1 and 1 microgram/ml. respectively and increased Con A-induced lymphoproliferation from 30,800 counts/min to 52,000 counts/min (P less than 0.01) at 0.1 microgram/mg and 51,1000 counts/min (P less than 0.005) at 1 microgram/ml. These results suggest that indomethacin enhanced mitogen-induced lymphoproliferative responses in vitro with cells from patients with AIDS and AIDS-related complex and may have therapeutic potential in some patients with AIDS.

Keywords: Acquired Immunodeficiency Syndrome/*DRUG THERAPY/IMMUNOLOGY Adjuvants, Immunologic Adult Concanavalin A/PHARMACOLOGY Human In Vitro Indomethacin/*PHARMACOLOGY Lymphocyte Transformation/*DRUG EFFECTS Male Middle Age Phytohemagglutinins/PHARMACOLOGY Pokeweed Mitogens/PHARMACOLOGY Support, Non-U.S. Gov't JOURNAL ARTICLE

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