Oral administration of human serum immunoglobulin in immunodeficient patients with viral gastroenteritis. A pharmacokinetic and functional analysis. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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Oral administration of human serum immunoglobulin in immunodeficient patients with viral gastroenteritis. A pharmacokinetic and functional analysis.

J Clin Invest. 1985 Dec;76(6):2362-7. Unique Identifier : AIDSLINE MED/86086388
Losonsky GA; Johnson JP; Winkelstein JA; Yolken RH

Abstract: We examined the pharmacokinetics and immunological activity of human serum immunoglobulins (HSG) possessing anti-rota-virus activity which were orally administered to three children with primary immunodeficiency syndromes and prolonged gastrointestinal excretion of rotavirus. Detailed analysis of the excretion of immunoglobulins labeled with biotin or I125 revealed that approximately 50% of the recovered radioactivity was excreted in the stools over a 3-d period. Approximately half of the excreted radioactivity recovered in the stool was in a macromolecular form with immunological activity. The remainder of the recovered radioactivity was excreted in the urine as low molecular weight fragments or free iodide. In addition, immunological and chromatographic analyses revealed that the oral administration of HSG resulted in the generation of rotavirus-specific immune complexes in the gastrointestinal tract with a subsequent decrease in the presence of uncomplexed rotavirus antigen. These studies indicate that orally administered HSG can survive passage in the gastrointestinal tract in an immunologically active form, and that the oral administration of immunoglobulins with specific reactivities has potential for the prevention or treatment of gastrointestinal infections.
Keywords: Adolescence Case Report Child, Preschool Gastroenteritis/ETIOLOGY/*THERAPY Human *Immunization, Passive Immunoglobulins/METABOLISM Immunologic Deficiency Syndromes/*COMPLICATIONS/THERAPY Infant Metabolic Clearance Rate Rotavirus Infections/ETIOLOGY/*THERAPY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDadolescencecasereportchild,preschoolgastroenteritis/etiology/KWDtherapyhumanKWDimmunization,passiveimmunoglobulins/metabolismimmunologicdeficiencysyndromes/KWDcomplications/therapyinfantmetabolicclearanceraterotavirusinfections/etiology/KWDtherapysupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
860430
M8640185

Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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