AIDS in two African children--one with fibrosarcoma of the liver. NLM AIDSLINE Important note: Information in this article was accurate in 1986. The state of the art may have changed since the publication date.

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AIDS in two African children--one with fibrosarcoma of the liver.

Eur J Pediatr. 1985 Nov;144(4):385-90. Unique Identifier : AIDSLINE MED/86081917
Ninane J; Moulin D; Latinne D; De Bruyere M; Scheiff JM; Duchateau J; Cornu G

Abstract: We report here on two black African girls who developed an acquired immune deficiency syndrome (AIDS). The first patient was a premature girl born to healthy parents. She suffered from interstitial pneumonitis during the first week of life and died of it at the age of 6 months. Her mother, although asymptomatic, had polyclonal hypergammaglobulinaemia, a reversed T-helper/T-suppressor ratio and a decreased lymphocyte response to mitogens. The second patient had the first symptoms at the age of 6 years, developed a primitive malignant fibrosarcoma of the liver at 8 years old and died 1 year later. AIDS can affect black African children who have not been transfused and whose family members are not considered as at a high risk for this disease. In children, AIDS and cancer can be associated. In the second patient, cytotoxic suppressor lymphocytes (OKT8 positive cells) were shown to behave in vitro as precursors of T-killer cells.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/*EPIDEMIOLOGY/ IMMUNOLOGY Antibodies, Monoclonal/IMMUNOLOGY Case Report Child Female Fibrosarcoma/*COMPLICATIONS Human Immunoglobulins/IMMUNOLOGY Infant Liver Neoplasms/*COMPLICATIONS Lymphocyte Transformation Lymphocytes/ULTRASTRUCTURE Microscopy, Electron T-Lymphocytes, Helper-Inducer/IMMUNOLOGY T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY Zaire JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/complications/KWDepidemiology/immunologyantibodies,monoclonal/immunologycasereportchildfemalefibrosarcoma/KWDcomplicationshumanimmunoglobulins/immunologyinfantliverneoplasms/KWDcomplicationslymphocytetransformationlymphocytes/ultrastructuremicroscopy,electront-lymphocytes,helper-inducer/immunologyt-lymphocytes,suppressor-effector/immunologyzairejournalarticle
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Copyright © 1986 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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