Tassi ZC; Silva Marques JC; Franceschett Ribeiro RM; Helau Rassi R; Furlaneto JA; Cestari Filho F; Rua Pedro de Toledo, 1800, HSPE-SP - DAR, 04039 Sao Paulo, Brasil
A case of acquired immunodeficiency syndrome (AIDS) is reported. The patient was a 45-yr-old male homosexual who presented with wt loss, diarrhea, cough, and dyspnea. Physical examination revealed fever, dehydration, oral and genital herpes , decreased breath sounds in the right
Hosp J. 1985 Fall;1(3):17-36. Unique Identifier : AIDSLINE AHA/86083755
Geis S; Fuller RL
AIDS, a recently discovered, contagious, potentially fatal disease has created alarm in some segments of our society. Policy makers in hospices and all facilities that care for dying patients can benefit from the experience of others who have already cared for AIDS patients. This article is a report about the experien
There is increasing number of cases of acquired immune deficiency syndrome (AIDS) and in France there have been about 100 cases. The authors report one case who died within 10 months. The patient presented a Pneumocystis carinii pneumonia, extensive peri-anal herpes, gastro-intesti
Tanphaichitra D; Sahaphong S; Srimuang S; Wangroongsarb Y
The AIDS syndrome includes cases of biopsy-proven Kaposi s sarcoma in persons under 60 years of age, or biopsy- or culture-proven Pneumocystis carinii pneumonia, or either of the life-threatening opportunistic infections in young previously healthy persons with no underlying cause of immunodeficiency (Center for Disea
Aust N Z J Ophthalmol. 1985 Aug;13(3):293-8. Unique Identifier : AIDSLINE MED/86077381
McCluskey PJ; Wakefield D
The acquired immune deficiency syndrome (AIDS) has reached epidemic proportions in the USA and the incidence of this potentially fatal viral infection is increasing rapidly in Australia . The loss of normal cellular immunity in affected individuals predisposes them to severe oppo
Ziegler-Heitbrock HW; Schramm W; Stachel D; Rumpold H; Kraft D; Wernicke D; von der Helm K; Eberle J; Deinhardt F; Rieber EP; et al
Immunological analysis of peripheral blood mononuclear cells (PBM) was performed in 20 patients with haemophilia A or B. One of the patients had never received clotting factor substitution in his life. Six different sources of lyophilized clotting factor were used for the other patients, but every given patient receiv
The effect of indomethacin on mitogen-induced lymphocyte proliferative responses was studied in six normal heterosexual subjects and nine patients with the acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC). Indomethacin enhanced only Con A-induced lymphocyte responses in six heterosexual men. I
Losonsky GA; Johnson JP; Winkelstein JA; Yolken RH
We examined the pharmacokinetics and immunological activity of human serum immunoglobulins (HSG) possessing anti-rota-virus activity which were orally administered to three children with primary immunodeficiency syndromes and prolonged gastrointestinal excretion of rotavirus. Detailed analysis of the excretion of immu
Eight patients with proved diagnoses of acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia, some with chronic sinusitis, pleural effusion, tuberculosis, and other pathologic conditions, were serially examined. Four had yellow discoloration of the distal portions of the nails. Nails of some patients
The authors anticipate that an increasing number of AIDS victims will be admitted to psychiatric inpatient units. The turmoil caused by the first AIDS patient admitted to the authors psychiatric unit is described. The authors then discuss staff difficulties from the perspective of the forces unique to this inpatient
Sex Transm Dis. 1985 Oct-Dec;12(4):229-34. Unique Identifier : AIDSLINE MED/86097224
McKusick L; Conant M; Coates TJ
The authors convened a conference at the University of California, San Francisco, to provide a framework for developing health education programs to reduce high-risk sexual activity associated with the acquired immunodeficiency syndrome (AIDS). Operating on a consensus model, four groups of experts defined the sexual
Prim Care. 1985 Dec;12(4):761-85. Unique Identifier : AIDSLINE MED/86094818
Bardin E; Berger RE
As sexual mores have changed, the primary care physician is increasingly challenged by patient sexually transmitted diseases. In this article, the authors attempt to aid in the proper diagnosis and management of men with sexually transmitted disease. Clinical understanding, approaches, and tables to direct management
Report of a now 2 8/12-year-old girl, who presented at the age of 8 months with chronic progressive pneumonia, mucocutaneous candidiasis, diarrhea, failure to thrive and a non-progressive paraplegia. The child s mother presented AIDS with pneumocystis carinii pneumonia and progressive general paralysis one year after
J Med Primatol. 1985;14(6):317-26. Unique Identifier : AIDSLINE MED/86089062
Eichberg JW; Alter HJ; Dreesman GR
Following inoculation with plasma from human patients with AIDS, two chimpanzees demonstrated specific antihuman T-cell leukemia virus type 3 (HTLV-III) antibodies. One of the two chimpanzees also developed massive lymphadenopathy that persisted for 32 weeks and demonstrated a concurrent and more frequent depression o
Sex Transm Dis. 1985 Oct-Dec;12(4):203-8. Unique Identifier : AIDSLINE MED/86097219
Haverkos HW; Pinsky PF; Drotman DP; Bregman DJ
To identify risk factors that determine the major manifestations of the acquired immunodeficiency syndrome (AIDS), the authors analyzed data from three epidemiologic studies conducted by the Centers for Disease Control. The authors compared patients by outcome of disease. Eighty-seven homosexual patients (47 with Kapo
Gill VJ; Park CH; Stock F; Gosey LL; Witebsky FG; Masur H
Patients with acquired immune deficiency syndrome may develop infection with mycobacteria, particularly Mycobacterium avium-M. intracellulare (MAI). These infections can frequently be associated with demonstrable mycobacteremia with the organism. In this study, we compared the sensitivity of a radiometric (BACTEC syst
Publications describing aspects of the coccidian protozoan parasite Cryptosporidium, increased greatly during 1983 and 1984 as a result of not only increasing veterinary interest but also in the role of the parasite in the newly recognised acquired immune deficiency syndrome (AIDS). The reports reflected widespread co
Acquired immune deficiency syndrome (AIDS)-related Kaposi s sarcoma (KS) is more virulent than previously reported cases of KS and affects a much younger population. The cell of origin is lymphatic endothelium, with the histopathology characterized by a proliferation of small vessels with abnormal endothelial cells, e
Monocyte function in rhesus monkeys with simian acquired immune deficiency syndrome (SAIDS) was compared with that in age-matched normal juvenile rhesus monkeys. The functional tests were 1) chemotaxis, 2) phagocytosis of opsonized Candida albicans, 3) killing and/or growth inhibition of Candida albicans, 4) generatio
A double fluorescent antibody method for quantitating human complement-fixing antibody to lymphocyte subclasses has been developed. The indicators in this system are a C6-deficient serum as a non-lytic source of complement, rhodamine-labeled anti-C3 and fluorescein-labeled murine monoclonal antibodies to human lymphoc
JAMA. 1986 Jan 10;255(2):209-11. Unique Identifier : AIDSLINE MED/86089462
Hardy AM; Rauch K; Echenberg D; Morgan WM; Curran JW
Acquired immunodeficiency syndrome (AIDS) is a serious, fatal disease affecting a relatively young population and has a great economic impact. Expenditures for hospitalization and economic losses from disability and premature death were estimated for the first 10,000 patients with AIDS reported in the
JAMA. 1986 Jan 17;255(3):383-4. Unique Identifier : AIDSLINE MED/86089499
Harfi HA; Fakhry BM
Two Saudi Arabian patients, one adult and one child, developed acquired immunodeficiency syndrome (AIDS) 2 1/2 and 3 1/2 years after blood transfusion. Both patients received blood imported from the United States in 1981. These are the first cases reported in Saudi Arabia. Since an und
Am J Med. 1986 Jan;80(1):119-22. Unique Identifier : AIDSLINE MED/86100520
Real FX; Krown SE; Koziner B
The development of Kaposi s sarcoma has been associated with either iatrogenic or disease-related immunodeficiency. This report describes a homosexual man who presented with Burkitt s lymphoma and later had pneumonitis, which was treated with a high dose of corticosteroids. Kaposi s sarcoma subsequently developed, and
Am J Med Sci. 1986 Jan;291(1):4-7. Unique Identifier : AIDSLINE MED/86100555
Pape JW; Liautaud B; Thomas F; Mathurin JR; St. Amand MM; Boncy M; Pean V; Pamphile M; Laroche AC; Johnson WD Jr
A total of 121 acquired immunodeficiency syndrome (AIDS) patients diagnosed in Haiti were studied between June 1979 and December 1983. Risk factors were identified in 65% of 34 patients evaluated in a standardized manner since July 1983 and included: bisexuality, 38%; blood transfus
Multiple opportunistic infections are characteristic of the acquired immunodeficiency syndrome (AIDS). Although bacterial pathogens have presented few problems, we have noted an emerging problem with salmonellal infection among patients with AIDS. A review of all stool and blood cultures from adults between January 19
Peripheral blood lymphocytes from 14 adult male patients admitted to the hospital with complications of intravenous drug abuse (IDA) were examined for natural killer (NK) and antibody-dependent cellular cytotoxic (ADCC) activities, lectin-dependent cellular cytotoxicity, and interferon (IFN)- and interleukin 2 (
Crit Care Med. 1986 Jan;14(1):1-4. Unique Identifier : AIDSLINE MED/86080764
Baumann WR; Jung RC; Koss M; Boylen CT; Navarro L; Sharma OP
We examined the incidence and mortality of adult respiratory distress syndrome (ARDS) in patients receiving emergency medical care at a large metropolitan medical center. The patients were classified into eight high-risk categories and monitored prospectively until discharge or death. Over a period of 12 months, 11,11
Dtsch Med Wochenschr. 1986 Jan 17;111(3):93-8. Unique Identifier : AIDSLINE MED/86081292
Stoll M; Peter HH; Lange ML; Wolff-Vorbeck G; Kemnitz J; Deicher H
Five cases (3 men, 2 women) of late-onset variable immunodeficiency syndrome (CVID), characterized by similar clinical and immunological findings as well as histological demonstration of chronic granulomatous infection, are reported. All patients had frequent attacks of respiratory infections with recurrent bronchitis
Simultaneous dual immunofluorescence and flow cytometry was used to study sixteen lymphocyte phenotypes in 209 men including: healthy homosexuals, lymphadenopathy patients (LAN), and AIDS patients. Significant differences between the distribution of lymphocytes in healthy homosexuals and healthy heterosexuals were dec
Although ketoconazole has been shown to be effective in treating esophageal candidiasis in other immunodeficiency states, similar studies have not been reported in patients with acquired immunodeficiency syndrome. Six patients with acquired immunodeficiency syndrome and oral and esophageal candidiasis who had been tre
Med Clin North Am. 1986 Jan;70(1):177-85. Unique Identifier : AIDSLINE MED/86090927
Jegasothy BV
The typing of cells in the skin with specific monoclonal antibodies is now routine. Such tissue typing appears to play a critical role in the early diagnosis, accurate classification, and therapeutic decisions for cutaneous oncology, especially lymphomas. Identification and production of tumor-specific antibodies will
Fiorilli M; Russo G; Paganelli R; Papetti C; Carbonari M; Crescenzi M; Calvani M; Quinti I; Aiuti F
We describe here one 8-year-old girl with an unusual form of immunodeficiency, characterized by hypogammaglobulinemia with hyper-IgM, severe T-cell defect, and chronic lymphadenopathy. Patient s B cells failed to produce IgG or IgA in vitro following stimulation with either pokeweed mitogen or Epstein-Barr virus, sugg
Patients with hemophilia are at risk for the development of acquired immunodeficiency syndrome (AIDS). Patients with AIDS have recurrent infections and/or malignancy and altered immune response, including decreased T lymphocyte counts, decreased T helper lymphocytes, defective T cell blastogenesis, hypergammaglobuline
Ninane J; Moulin D; Latinne D; De Bruyere M; Scheiff JM; Duchateau J; Cornu G
We report here on two black African girls who developed an acquired immune deficiency syndrome (AIDS). The first patient was a premature girl born to healthy parents. She suffered from interstitial pneumonitis during the first week of life and died of it at the age of 6 months. Her mother, although asymptomatic, had p
Many cutaneous disorders are associated with acquired immunodeficiency syndrome. We prospectively evaluated eighteen patients with acquired immunodeficiency syndrome and twelve patients with the immunodeficiency syndrome-related complex for dermatologic disorders. A high prevalence of seborrheic dermatitis was found i
Caluser I; Mocanu G; Olinici CD; Iconomou D; Spanudakis S
A 40-year-old male showed a syndrome of acquired immunodeficiency after a prolonged use of antidiabetic sulfamides. The lesions were revealed by the biopsic examination of inguinal lymph nodes. Immunodeficiencies are usually associated with malignant lymphoma: our case was, however, associated with Kaposi s sarcoma.
On the basis of four cases of patients with persistent lymphadenopathy and at risk for acquired immune deficiency syndrome (AIDS), (3 Haitians, one haemophiliac), histopathologic features of lymph node biopsy in AIDS are recalled. Two main types of alterations of lymph node architecture--follicular hyperplasia or lymp
Lymphocytes from 16 AIDS patients were tested in the cell-mediated lympholysis assay (CML). The ability to produce alloreactive cytotoxic lymphocytes in vitro was found to be substantially reduced when compared with concomitantly investigated normal controls. Addition of interleukin 2 (
T-cell chronic lymphocytic leukemia (T-CLL) accounts for about 2% of the various types of CLL and can be subtyped into helper/inducer (h/i) and cytotoxic/suppressor (c/s) cell membrane phenotypes. Seven patients with CLL were shown to have T-CLL with a h/i cell membrane phenotype; four with monoclonal antibody reagent
Boll Ist Sieroter Milan. 1985;64(4):339-42. Unique Identifier : AIDSLINE MED/86077320
Cuneo Crovari P; Terragna A; Robert L; Orlando G; Rizzo F; Piuma-Fusco M; Icardi GC; Papa D; Di Ponzio A; Auteri G; et al
Anti-HTLV III prevalence has been investigated in serum samples of 638 intravenous drug users collected over May 1981 - March 1985 and stored at -20 degrees C. Separately, in a prospective way, we have studied 68 IV drug abusers (53 Genoese and 15 of Sanremo area) of whom we have collected, at least, one serum specime
Antin JH; Smith BR; Ewenstein BM; Arceci RJ; Lipton JM; Page PL; Rappeport JM
We prospectively documented the development of a fatal, secondarily acquired severe immunodeficiency in a 19-year-old man who underwent uncomplicated bone marrow transplantation. He had no graft v host disease (GVHD) and had normal recovery of his immune system as determined by lymphocyte phenotyping, mitogenic respon
Bronchoalveolar lavage (BAL) has been performed in 63 patients with acquired immune deficiency syndrome (AIDS) and 20 patients with chronic generalized lymphadenopathy (CGL) for the diagnosis of lung opportunistic infections and analysis of immune effector cells of the lower respiratory tract. In patients with AIDS, P
Shiigi SM; Wilson BJ; Malley A; Howard CF Jr; McNulty WP; Olson L; Olson S; Regan D; Burger D; Marx PA
Celebes black macaques (Macaca nigra) with a history of diabetes mellitus, recurrent bacterial and protozoal infections, diarrhea, anemia, weight loss, anorexia, and a high mortality were studied to determine their immune status. Two groups of monkeys, healthy and unhealthy, were formed on the basis of a clinical asse
Because the expression of interleukin 2 ( IL-2 ) receptor and transferrin receptor is essential for the proliferation of T cells to mitogens and antigens, we examined the expression of monoclonal antibody defined IL-2 receptor (Tac antigen) and transferrin receptor on un
Plasmas from acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC) patients were screened for their ability to inhibit mitogen-induced proliferation of normal human lymphocytes. Plasmas from 67% of the individuals examined contained significant suppressive activity. Additional studies on the mechan
Cone LA; Woodard DR; Potts BE; Byrd RG; Alexander RM; Last MD
The pandemic, acquired immunodeficiency syndrome (AIDS) has been described in 40 nations throughout the world. This paper describes the wide spectrum of gastrointestinal tract manifestations seen in this syndrome, with particular attention to the epidemiology, etiology, and measurement of these problems. Discussion of
Antibodies to human T-cell lymphotropic virus type III (HTLV-III Ab) were present in twenty-one out of sixty-four asymptomatic promiscuous homosexual men from Copenhagen. The presence of HTLV-III Ab was associated with lymphadenopathy (P less than 0.0005), cytomegalovirus isolation
We report a case of epidermotropic high-grade malignant lymphoma associated with hypercalcemia occurring in a European woman aged 30 years. The clinical, histological, and biological presentation of the patient could enter the spectrum of HOTS (hypercalcemia, osteolysis, T cell lymphoma syndrome). The proliferation of
Int J Cancer. 1986 Jan 15;37(1):35-42. Unique Identifier : AIDSLINE MED/86084576
Tanaka Y; Lee B; Inoi T; Tozawa H; Yamamoto N; Hinuma Y
Three distinct monoclonal antibodies (MAbs) specific for human T-cell leukemia virus type-I (HTLV-I) core proteins with molecular weights of 24 kDa (p24), p19 or p15 were produced, characterized and compared. These antibodies were named NOR-1 (anti-p24, IgG2a), GIN-7 (anti-p19, IgG2b) and FR-45 (anti-p15, IgG2a). Immu
Int J Cancer. 1986 Jan 15;37(1):67-72. Unique Identifier : AIDSLINE MED/86084581
Markham PD; Salahuddin SZ; Veren K; Orndorff S; Gallo RC
The ability to productively infect fresh normal human peripheral blood mononuclear leukocytes with HTLV-III was improved by supplementing cell culture medium with either the gonadal steroid, chorionic gonadotropin, or insulin, and more substantially with the adrenocortical steroid, hydrocortisone. Several other sex ho
The first pediatric case of acquired immunodeficiency syndrome (AIDS) observed in Switzerland is described. The 3-year-old African/Swiss patient was most probably vertically infected from her asymptomatic, HTLV-III antibody positive Zairian mother. Clinical symptomatology star
Tsujimoto H; Seiki M; Nakamura H; Watanabe T; Sakakibara I; Sasagawa A; Honjo S; Hayami M; Yoshida M
Spontaneous T-cell leukemia similar to human adult T-cell leukemia (ATL) was found in an African green monkey naturally infected with simian retrovirus closely related to human T-cell leukemia virus type I (HTLV-I). Monoclonal integration of the simian retrovirus was detected in the primary leukemic cells, suggesting
Neurath AR; Strick N; Lee YS; Nilsen T; Baker L; Sproul P; Rubinstein P; Taylor P; Stevens CE; Gold JW
The acquired immunodeficiency syndrome (AIDS) may be transmitted by blood transfusions and by blood products from donors who have been infected with the lymphadenopathy-associated virus (LAV). Such donors may generally be identified on the basis of a positive test for antibodies-against LAV proteins. We have already d
The clinical spectrum of human T cell lymphotropic virus type III (HTLV-III) disease is associated with myriad cutaneous findings, commonly of infectious origin. A clinically characteristic, yet histologically nonspecific, papular eruption was observed in seven of thirty-five patients followed up for HTLV-III disease
We review a spectrum of unusual infectious, nutritional, and malignant processes that have been observed in the skin of patients with acquired immunodeficiency syndrome.
Recombinant retroviruses containing the trans activator genes of human T-cell leukemia virus (HTLV) type II and human T-cell lymphotropic virus type III were constructed. The trans activator genes tat II and tat III were inserted into the murine retroviral vector pZIPNEOSV(X)1. Recombinant plasmids were transfected in
Previous results from our laboratory have demonstrated that equine infectious anemia virus displays structural variations in its surface glycoproteins and RNA genome during passage and chronic infections in experimentally infected Shetland ponies (Montelaro et al., J. Biol. Chem. 259:10539-10544, 1984; Payne et al., J
JAMA. 1986 Jan 10;255(2):212-5. Unique Identifier : AIDSLINE MED/86089463
Jason JM; McDougal JS; Dixon G; Lawrence DN; Kennedy MS; Hilgartner M; Aledort L; Evatt BL
We evaluated the human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody and immune status of 88 persons living with and/or sexual partners of 43 hemophiliacs, 12 of whom had AIDS, five of whom had AIDS-related complex (ARC), 17 of whom were clinically well but HTLV-III/LAV an
JAMA. 1986 Jan 24-31;255(4):505-7. Unique Identifier : AIDSLINE MED/86089518
Curt GA; Katterhagen G; Mahaney FX Jr
Immunoaugmentative therapy is an unproved cancer treatment that until recently was offered to patients by zoologist Lawrence Burton, PhD, at a facility in Freeport, Bahamas . The therapy consists of serum measurements of certain immune deficiencies and purportedly restores immune f
Franchini G; Mann DL; Popovic M; Zicht RR; Gallo RC; Wong-Staal F
We analysed the DNA of different tissues of a patient (HS) with adult T-cell leukemia/lymphoma virus (HTLV-I). We detected viral sequences in fresh specimens from spleen, thymus, liver, skin and peripheral blood neoplastic lymphocytes. The pattern of HTLV-I integration is identical in the leukemic cells and in all oth
Med Clin North Am. 1986 Jan;70(1):139-54. Unique Identifier : AIDSLINE MED/86090925
Muggia FM; Lonberg M
Mucocutaneous lesions are often a prominent manifestation of the acquired immune deficiency syndrome (AIDS). Patients with this syndrome are susceptible to a number of opportunistic skin infections as well as an aggressive form of Kaposi s sarcoma. The diagnosis, the clinical setting, and the treatment of these diseas
Otto HF; Weidauer H; Moller P; Nemetschek-Gansler H; Franke WW; De Villiers EM; Braun RW
AIDS-related lymphoadenopathy is characterised by follicular hyperplasia with irregularities in the dendritic network, a loss of the follicular mantle zone and an enhanced influx of T-suppressor cells into the germinal centres. The histological features of AIDS-associated epidemic Kaposi s sarcoma are spindle-like tum
Tanaka Y; Tozawa H; Hayami M; Sugamura K; Hinuma Y
Two new murine monoclonal IgG1 antibodies, H-31 and H-A26, were characterized in comparison with two previously obtained monoclonal antibodies against human interleukin 2 ( IL-2 ) receptor (IL-2 R), anti-Tac and HIEI. In immunofluorescence assays with various human hemat
Nature. 1986 Jan 23-29;319(6051):333-6. Unique Identifier : AIDSLINE MED/86092253
Mullins JI; Chen CS; Hoover EA
Feline leukaemia viruses (FeLVs) have long been known to be associated with induction of proliferative and anti-proliferative diseases of domestic cats. Strains of FeLV have been recognized which specifically induce lymphosarcoma, aplastic anaemia, myelodysplastic anaemia, and, recently, feline AIDS (acquired immune d
N Z Med J. 1985 Nov 27;98(791):992-3. Unique Identifier : AIDSLINE MED/86093042
Field D; Whyte G; Robertson S
The Christchurch Hospital blood bank has assessed commercial kits designed to test blood donations for the presence of antibody to the retrovirus responsible for acquired immune deficiency syndrome (AIDS). Twenty of 1002 blood donations have been found to be repeatably, positive by one or more of these commercial kits
Pathol Res Pract. 1985 Nov;180(5):463-80. Unique Identifier : AIDSLINE MED/86094010
Krueger GR; Otten JK; Ortmann M; Muller W; Haussermann L; Rasokat H; Degenhardt S; Hehlmann R; Wolf H; Auffermann W; et al
Sequential changes in the morphology of immunocompetent and other organs, in the accompanying immunocytological and immunovirological measurements are described in 75 patients with lymphadenopathy syndrome and with AIDS. The data presented demonstrate a stepwise development of the disease from a hyperimmunization synd
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8359-63. Unique Identifier : AIDSLINE MED/86094225
Kiyokawa T; Seiki M; Iwashita S; Imagawa K; Shimizu F; Yoshida M
Human T-cell leukemia virus type I (HTLV-I) is an etiological agent of adult T-cell leukemia and has a unique sequence, pX, that contains four possible open reading frames, I-IV. p40x was previously identified as the gene product of frame IV (x-lor) and was suggested to mediate transcriptional trans-activation of the
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8691-5. Unique Identifier : AIDSLINE MED/86094290
Arya SK; Gallo RC
Acquired immune deficiency syndrome (AIDS) is characterized by severe depletion of OKT4+ T lymphocytes and leukemia is associated with abnormal proliferation of maturation-arrested lymphocytes. Human T-lymphotropic virus type III (HTLV-III) or lymphoadenopathy virus (LAV) and type I (HTLV-I) are etiologically linked t
Proc Natl Acad Sci U S A. 1986 Jan;83(1):38-42. Unique Identifier : AIDSLINE MED/86094346
Aldovini A; De Rossi A; Feinberg MB; Wong-Staal F; Franchini G
The genome of the human T-cell leukemia/lymphotropic virus type I (HTLV-I) contains a functional gene denominated x-lor that may be important in HTLV-I transformation of human T cells. To study the role of x-lor and other HTLV-I genes in cellular transformation, we obtained a transformed nonproducer human T-cell line
Three enzymo immuno assay kits for the detection of anti-LAV/HTLV III antibodies were evaluated: Diagnostics Pasteur (Elavia) Abbott Laboratories (Abbott/HTLV III) and Organon (Vironostika). A total of 6017 blood donors (5980 unselected and 37 prisoners) and a panel of 55 sero neg
18 out of 40 healthy Danish type A haemophiliacs had antibodies against HTLV-III as measured by an enzyme linked immunosorbent assay (ELISA). The overall seropositivity was 45%. A significant positive correlation was found between seropositivity and total lifetime dose of factor VIII and the age of the patients. 63% a
Human T-lymphotropic virus type III (HTLV-III) or lymphadenopathy-associated virus (LAV) is tropic for human T cells with the helper-inducer phenotype, as defined by reactivity with monoclonal antibodies specific for the T4 molecule. Treatment of T4+ T cells with monoclonal antibodies to T4 antigen blocks HTLV-III/LAV
S Afr Med J. 1985 Dec 21;68(13):921-2. Unique Identifier : AIDSLINE MED/86097144
Milner LV; Vorster BJ; Conradie JD; Brain P
Screening blood donations for anti-HTLV-III with a modification to a commercially available test kit has so far been found satisfactory--the reagent cost is less than R1.00 a donation. Should all transfusion services adopt this method, South Africa s total blood donations could be tested at a cost of about R650 000, i
Although the etiologic agent of AIDS has been identified, clinicians are still left with treating the complications of this immune deficiency, that is, the unusual neoplasms such as KS and the myriad of opportunistic infections. Efforts at immune reconstitution, including bone marrow transplantation from a normal iden
The acquired immune deficiency syndrome (AIDS) retrovirus, HTLV-III/LAV, encodes a transacting factor which directly or indirectly stimulates the expression of genes linked to its LTR. To further dissect this phenomenon, we have cotransfected a biologically active molecular clone of HTLV-III and a recombinant plasmid
Virology. 1986 Jan 30;148(2):385-8. Unique Identifier : AIDSLINE MED/86098688
Watanabe T; Seiki M; Hirayama Y; Yoshida M
The nucleotide sequences of the long terminal repeat (LTR) of simian retroviruses (STLV), which are closely related to human T-cell leukemia virus type I (HTLV-I) were found to be of at least two subgroups: an Asian subtype in macaques and an African subtype in African green monkeys and chimpanzee. The nucleotide sequ
Wien Klin Wochenschr. 1985 Nov 22;97(22):829-32. Unique Identifier : AIDSLINE MED/86098864
Kunz C; Heinz FX
Three commercially available ELISA test kits were used for the detection of antibodies to HTLV-III, the cause of AIDS. Positive results were confirmed by means of the Western Blot. In the course of our routine diagnostic studies, a total of 112 infections with HTLV-III were found among persons in high-risk groups or i
Am J Ophthalmol. 1986 Jan 15;101(1):95-101. Unique Identifier : AIDSLINE MED/86100636
Palestine AG; Stevens G Jr; Lane HC; Masur H; Fujikawa LS; Nussenblatt RB; Rook AH; Manischewitz J; Baird B; Megill M; et al
Eight patients with cytomegalovirus retinitis in one or both eyes were treated with 9-(1,3 dihydroxy 2-propoxymethyl) guanine. Of the 14 eyes with retinitis, eight demonstrated more than 90% resolution, four had partial improvement, one failed to respond, and one could not be evalu
Acquired immune deficiency syndrome (AIDS) has been rarely reported as occurring primarily in Asia. We report here on first three cases of AIDS diagnosed at Chulalongkorn Hospital Medical School. One case was an American who had been in Thailand for two years; the other two were
Cancer Res. 1986 Feb;46(2):658-61. Unique Identifier : AIDSLINE MED/86079155
Shirakawa F; Yamashita U; Oda S; Chiba S; Eto S; Suzuki H
The effects of calcium, calcium antagonists, and calmodulin inhibitors on the growth of adult T-cell leukemia (ATL) cells were studied in vitro. Fresh ATL cells from patients and established ATL cell lines did not grow well in a low-calcium (less than 0.01 mM) medium. However, their growth was enhanced by the addition
Granulomatous amebic encephalitis due to Acanthamoeba spp. usually occurs in chronically ill and debilitated individuals. Some of these patients may have received immunosuppressive therapy. Another infection due to Acanthamoeba spp. has been corneal ulcerations which usually occur after minimal trauma to the corneal e
Adult T-cell leukemia (ATL) has a range of clinical characteristics. Phenotypically the leukemic cells usually express the helper/inducer associated antigen OKT4 with lack of OKT8. We have observed three patients with acute ATL cytologically indistinguishable from OKT4+/OKT8- ATL but whose neoplastic cells had the unu
Lancet. 1985 Dec 21-28;2(8469-70):1387-9. Unique Identifier : AIDSLINE MED/86091119
Barin F; M'Boup S; Denis F; Kanki P; Allan JS; Lee TH; Essex M
Serological evidence is presented here suggesting that a virus closely related to simian T-lymphotropic virus type III (STLV-III) infects man in Senegal , west Africa, a region where AIDS or AIDS-related diseases have not yet been observed. 25 sera from Senegalese individuals that
Lancet. 1985 Dec 21-28;2(8469-70):1390-3. Unique Identifier : AIDSLINE MED/86091120
Andiman WA; Eastman R; Martin K; Katz BZ; Rubinstein A; Pitt J; Pahwa S; Miller G
Two types of lymphoproliferative disease associated with Epstein-Barr viral (EBV) DNA--central-nervous-system lymphoma and chronic lymphocytic interstitial pneumonitis (LIP)--were recognised in children with human T-lymphotropic virus type III/lymphadenopathy virus infection and the acquired immunodeficiency syndrome
Toth FD; Vaczi L; Szabo B; Kiss J; Rethy A; Kiss A; Telek B; Kovacs I; Kiss C; Rak K
Peripheral leukocytes or lymph node cells and blood plasma samples from patients with lymphoid malignancies were investigated for immunological markers of BaEV, GaLV and HTLV. Antigens and antibodies were shown with radioimmunoassay. Antigen related to the p30 core protein of BaEV could be detected in each cell type o
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