Unexpected toxicity from radiation therapy in two patients with Kaposi's sarcoma receiving interferon. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Unexpected toxicity from radiation therapy in two patients with Kaposi's sarcoma receiving interferon.

J Biol Response Mod. 1985 Apr;4(2):141-6. Unique Identifier : AIDSLINE MED/85209935
Real FX; Krown SE; Nisce LZ; Oettgen HF

Abstract: Two homosexual men with Kaposi's sarcoma and acquired immune deficiency received radiation therapy to the oral mucosa while treatment with recombinant leukocyte A interferon was being given systemically at a dose of 36 million units. Symptoms of radiation mucositis developed after the administration of 900 rad in the first patient and 1,050 rad in the second patient. Radiation therapy had to be stopped after doses of 1,100 and 2,100 rad, respectively, had been given. Both patients had to be admitted to the hospital for supportive care and the second patient required placement of a feeding tube. To our knowledge, no other clinical observations suggesting interactions of radiation therapy and interferon have been reported. We discuss the results of experiments with cultured cells and experimental animals which suggest that such interactions occur and may be successfully exploited therapeutically.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS Adult Case Report Human Interferon Type I/*THERAPEUTIC USE Male Middle Age Mouth Mucosa/*RADIATION EFFECTS *Radiation Injuries Sarcoma, Kaposi's/*RADIOTHERAPY/THERAPY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/complicationsadultcasereporthumaninterferontypei/KWDtherapeuticusemalemiddleagemouthmucosa/KWDradiationeffectsKWDradiationinjuriessarcoma,kaposi's/KWDradiotherapy/therapysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
850930
M8590142

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1985. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .