Pseudomembranous necrotizing bronchial aspergillosis. A variant of invasive aspergillosis in a patient with hemophilia and acquired immune deficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Pseudomembranous necrotizing bronchial aspergillosis. A variant of invasive aspergillosis in a patient with hemophilia and acquired immune deficiency syndrome.

Am Rev Respir Dis. 1985 Jun;131(6):961-3. Unique Identifier : AIDSLINE MED/85223440
Pervez NK; Kleinerman J; Kattan M; Freed JA; Harris MB; Rosen MJ; Schwartz IS

Abstract: A 15-yr-old male hemophiliac developed the acquired immune deficiency syndrome (AIDS). His terminal illness was characterized by rapidly progressive respiratory failure with intermittent wheezing, nonresponsive to bronchodilator and steroid therapy. Postmortem examination revealed a pseudomembrane covering the mucosa of the lower trachea and bronchi of both lungs. This pseudomembrane was composed predominantly of fungal hyphae speciated as Aspergillus niger. There was widespread transmural necrotizing bronchitis and fungal invasion that extended to involve a narrow zone of peribronchial tissues. The intervening lung parenchyma was free of fungal disease. This unique form of bronchitis is a distinct variant of invasive aspergillosis and merits recognition because of its clinical and prognostic implications.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adolescence Aspergillosis/*COMPLICATIONS/PATHOLOGY/RADIOGRAPHY Aspergillus niger Bronchi/PATHOLOGY Bronchial Diseases/*COMPLICATIONS/PATHOLOGY/RADIOGRAPHY Case Report Hemophilia/*COMPLICATIONS Human Male Necrosis Thoracic Radiography JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsadolescenceaspergillosis/KWDcomplications/pathology/radiographyaspergillusnigerbronchi/pathologybronchialdiseases/KWDcomplications/pathology/radiographycasereporthemophilia/KWDcomplicationshumanmalenecrosisthoracicradiographyjournalarticle
850930
M8590119

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