Oligoclonal immunoglobulins in patients with the acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Oligoclonal immunoglobulins in patients with the acquired immunodeficiency syndrome.

Clin Immunol Immunopathol. 1985 Apr;35(1):43-6. Unique Identifier : AIDSLINE MED/85202390
Papadopoulos NM; Lane HC; Costello R; Moutsopoulos HM; Masur H; Gelmann EP; Fauci AS

Abstract: Analysis of serum samples from patients with the acquired immunodeficiency syndrome (AIDS) was performed by high-resolution zone electrophoresis. A high incidence of monoclonal and oligoclonal immunoglobulins was detected in the sera of 24/27 patients with Kaposi's sarcoma and in 2/15 patients with opportunistic infections. The presence of monoclonal bands was independent of whether or not the patients had experienced an opportunistic infection. These findings indicate a monoclonal or oligoclonal B-cell activation occurring in a much higher frequency in AIDS patients with Kaposi's sarcoma, thus suggesting that similar mechanisms may be operative in the malignant or pseudomalignant proliferation of B-cells and endothelial cells in patients with AIDS.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Antibodies, Monoclonal/*IMMUNOLOGY B-Lymphocytes/IMMUNOLOGY Bacterial Infections/IMMUNOLOGY Human IgA/ANALYSIS IgG/ANALYSIS Immunoglobulins/*ANALYSIS Male Sarcoma, Kaposi's/IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyantibodies,monoclonal/KWDimmunologyb-lymphocytes/immunologybacterialinfections/immunologyhumaniga/analysisigg/analysisimmunoglobulins/KWDanalysismalesarcoma,kaposi's/immunologyjournalarticle
850930
M8590102

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1985. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .