Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III.

Science. 1985 Jun 7;228(4704):1199-201. Unique Identifier : AIDSLINE MED/85218784
Kanki PJ; McLane MF; King NW Jr; Letvin NL; Hunt RD; Sehgal P; Daniel MD; Desrosiers RC; Essex M

Abstract: Human T-lymphotropic virus type III (HTLV-III) is thought to play an etiologic role in the development of the acquired immune deficiency syndrome (AIDS). In this study the serologic characterization of a new simian retrovirus that is related to HTLV-III is described. This new virus, here referred to as STLV-III, was isolated from sick macaques at the New England Regional Primate Research Center. Radioimmunoprecipitation analysis revealed STLV-III-specific proteins of 160, 120, 55, and 24 kilodaltons, all similar in size to the major gag and env proteins of HTLV-III. These antigens were recognized by representative macaque serum samples and human reference serum samples positive for HTLV-III antibodies. Monoclonal antibodies directed to p24, the major core protein of HTLV-III, also immunoprecipitated a 24-kilodalton species in lysates of cells infected with the macaque virus. This HTLV-III-related virus, which naturally infects a nonhuman primate species, may provide a useful model for the study of HTLV-III and the pathogenesis of AIDS.
Keywords: Acquired Immunodeficiency Syndrome/*VETERINARY Animal Antigens, Viral/ANALYSIS Glycoproteins/IMMUNOLOGY Lymphoma/MICROBIOLOGY Macaca/*MICROBIOLOGY Molecular Weight Monkey Diseases/MICROBIOLOGY Retroviridae/*IMMUNOLOGY/ISOLATION & PURIF Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/*MICROBIOLOGY Viral Proteins/IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDveterinaryanimalantigens,viral/analysisglycoproteins/immunologylymphoma/microbiologymacaca/KWDmicrobiologymolecularweightmonkeydiseases/microbiologyretroviridae/KWDimmunology/isolation&purifsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/KWDmicrobiologyviralproteins/immunologyjournalarticle
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M8590101

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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