Naturally occurring antibodies reactive with sperm proteins: apparent deficiency in AIDS sera. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Naturally occurring antibodies reactive with sperm proteins: apparent deficiency in AIDS sera.

Science. 1985 Jun 7;228(4704):1211-5. Unique Identifier : AIDSLINE MED/85218789
Rodman TC; Laurence J; Pruslin FH; Chiorazzi N; Winston R

Abstract: A set of naturally occurring immunoglobulin M (IgM) antibodies that are reactive with a defined subset of proteins in the acrosomal cap region of human sperm has been identified. These antibodies are present in a broad spectrum of human sera from males and females, 1 day to 40 years of age, and are absent or markedly deficient in a large proportion of sera from individuals with the acquired immune deficiency syndrome (AIDS) or at risk for AIDS. The subset of proteins with which the IgM antibodies are reactive includes a factor (or factors) capable of inhibiting lectin-induced T-lymphocyte proliferation. The prevalence of the sperm-reactive IgM antibodies indicates that they are not elicited by sperm. Further, immunoreactivity of the sperm proteins resulting in depletion of specific circulating IgM antibodies, or other interactions between the sperm proteins and elements of the immune system, may be a factor in the suppressed state of the immune system in AIDS.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Acrosome/*IMMUNOLOGY Adolescence Adult Antibodies/ANALYSIS Child Child, Preschool Female Fluorescent Antibody Technique Human IgM/ANALYSIS Infant Male Molecular Weight Spermatozoa/*IMMUNOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyacrosome/KWDimmunologyadolescenceadultantibodies/analysischildchild,preschoolfemalefluorescentantibodytechniquehumanigm/analysisinfantmalemolecularweightspermatozoa/KWDimmunologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/immunologyjournalarticle
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M8590096

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