Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Isolation of T-cell tropic HTLV-III-like retrovirus from macaques.

Science. 1985 Jun 7;228(4704):1201-4. Unique Identifier : AIDSLINE MED/85218785
Daniel MD; Letvin NL; King NW; Kannagi M; Sehgal PK; Hunt RD; Kanki PJ; Essex M; Desrosiers RC

Abstract: The isolation of a T-cell tropic retrovirus from three immunodeficient macaques and one macaque with lymphoma is described. The morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of acquired immune deficiency syndrome in humans (HTLV-III or LAV). This virus is referred to as simian T-lymphotropic virus type III (STLV-III) of macaques. The existence of a cytopathic, T-cell tropic virus resembling HTLV-III in monkeys may facilitate study of disease induction and vaccine development in an animal model.
Keywords: Acquired Immunodeficiency Syndrome/*VETERINARY Animal Lymphoma/MICROBIOLOGY/VETERINARY Macaca/*MICROBIOLOGY Macaca mulatta/*MICROBIOLOGY Monkey Diseases/*MICROBIOLOGY Retroviridae/*ISOLATION & PURIF Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/*MICROBIOLOGY T-Lymphocytes, Helper-Inducer/MICROBIOLOGY Virus Replication JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDveterinaryanimallymphoma/microbiology/veterinarymacaca/KWDmicrobiologymacacamulatta/KWDmicrobiologymonkeydiseases/KWDmicrobiologyretroviridae/KWDisolation&purifsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/KWDmicrobiologyt-lymphocytes,helper-inducer/microbiologyvirusreplicationjournalarticle
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M8590077

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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