Glycosphingolipids of leukemic cells in adult T-cell leukemia-lymphoma. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Glycosphingolipids of leukemic cells in adult T-cell leukemia-lymphoma.

Biochim Biophys Acta. 1985 May 17;834(3):396-401. Unique Identifier : AIDSLINE MED/85200008
Kuriyama M; Nomura K; Tara M; Matsubara H; Igata A

Abstract: We analyzed lipids from leukemic cells of two patients with adult T-cell leukemia and compared them with those from T-cell lymphocytes of normal subjects. The neutral glycosphingolipids and gangliosides which were isolated were characterized by thin-layer chromatography and neuraminidase treatment. Both leukemic cells and normal lymphocytes had monoglycosylceramide and diglycosylceramide as major neutral glycosphingolipids. In one patient, diglycosylceramide was markedly increased. II3NeuAc-LacCer (GM3) and more complex gangliosides were detected in both cells. The most characteristic finding in leukemic cells was the occurrence of a disialylated ganglioside, II3(NeuAc)2-LacCer (GD3), which is not found in normal lymphocytes and neutrophils. This ganglioside may be due to the induced synthesis in association with malignant transformation.
Keywords: Cell Membrane/METABOLISM Chromatography, Thin Layer Gangliosides/METABOLISM Glycosphingolipids/*METABOLISM Human HTLV-BLV Viruses Retroviridae Infections/*METABOLISM T-Lymphocytes/*METABOLISM JOURNAL ARTICLE

KWDcellmembrane/metabolismchromatography,thinlayergangliosides/metabolismglycosphingolipids/KWDmetabolismhumanhtlv-blvvirusesretroviridaeinfections/KWDmetabolismt-lymphocytes/KWDmetabolismjournalarticle
850930
M8590075

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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